Crystallization of (20R) and (20S) analogs of 2-methylene-19-nor-24-dimethyl-1α,25-dihydroxyvitamin D3

ABSTRACT

Disclosed are methods of purifying (20R) and (20S) analogs of 2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D 3  to obtain the (20R) and (20S) analogs in crystalline form. The method includes the steps of preparing a solvent of either diethyl ether or a mixture of 2-propanol and hexane, dissolving a product containing the (20R) and (20S) analog to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals.

CROSS-REFERENCE TO RELATED PATENT APPLICATIONS

The present application claims the benefit under 35 U.S.C. §119(e) toU.S. Provisional Patent Application No. 61/652,965, filed on May 30,2012, the content of which is incorporated herein by reference in itsentirety.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

This invention was made with government support under DK047814 awardedby the National Institutes of Health. The government has certain rightsin the invention.

BACKGROUND

The field of the present invention relates to purification of organiccompounds, and more particularly to the purification of (20S) and (20R)analogs of 2-Methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃(referred to herein as “MET-1” and “MET-2” respectively) by preparingthem in crystalline form.

Purification of organic compounds, especially those designated forpharmaceutical use, is of considerable importance for chemistssynthesizing such compounds. Preparation of the compound usuallyrequires many synthetic steps and, therefore, the final product can becontaminated not only with side-products derived from the last syntheticstep of the procedure but also with compounds that were formed inprevious steps. Even chromatographic purification, which is a veryefficient but relatively time-consuming process, does not usuallyprovide compounds which are sufficiently pure to be used as drugs.

Depending on the method used to synthesize 1α-hydroxyvitamin Dcompounds, different minor undesirable compounds can accompany the finalproduct. Thus, for example, if direct C-1 hydroxylation of the 5,6-transgeometric isomer of vitamin D is performed, followed by SeO₂/NMOoxidation and photochemical irradiation, (see Andrews et al., J. Org.Chem. 51, 1635 (1986); Calverley et al., Tetrahedron 43, 4609 (1987);Choudry et al., J. Org. Chem. 58, 1496 (1993)), the final1α-hydroxyvitamin D product can be contaminated with 1β-hydroxy—as wellas 5,6-trans isomers. If the method consists of C-1 allylic oxidation ofthe 4-phenyl-1,2,4-triazoline-3,5-dione adduct of the pre-vitamin Dcompound, followed by cycloreversion of the modified adduct under basicconditions, (see Nevinckx et al., Tetrahedron 47, 9419 (1991); Vanmaeleet al., Tetrahedron 41, 141 (1985) and 40, 1179 (1994); Vanmaele et al.,Tetrahedron Lett. 23. 995 (1982)), one can expect that the desired1α-hydroxyvitamin can be contaminated with the pre-vitamin 5(10),6,8-triene and 1β-hydroxy isomer. One of the most useful C-1hydroxylation methods, of very broad scope and numerous applications, isthe experimentally simple procedure elaborated by Paaren et al., J. Org.Chem. 45, 3253 (1980) and Proc. Natl. Acad. Sci. U.S.A. 75, 2080 (1978).This method consists of allylic oxidation of 3,5-cyclovitamin Dderivatives, readily obtained from the buffered solvolysis of vitamin Dtosylates, with SeO₂/t-BuOOH and subsequent acid-catalyzedcycloreversion to the desired 1α-hydroxy compounds. Taking into accountthis synthetic path, it is reasonable to assume that the final productcan be contaminated with 1α-hydroxy epimer, 5,6-trans isomer and theprevitamin D form. 1α-hydroxyvitamin D₄ is another undesirablecontaminant found in 1α-hydroxyvitamin D compounds synthesized fromvitamin D₂ or from ergosterol. 1α-hydroxyvitamin D₄ results from C-1oxidation of vitamin D₄, which in turn is derived from contamination ofthe commercial ergosterol material. Typically, the final product maycontain up to about 1.5% by weight 1α-hydroxyvitamin D₄. Thus, apurification technique that would eliminate or substantially reduce theamount of 1α-hydroxyvitamin D₄ in the final product to less than about0.1-0.2% would be highly desirable.

The vitamin D conjugated triene system is not only heat- andlight-sensitive but it is also prone to oxidation, leading to thecomplex mixture of very polar compounds. Oxidation usually happens whena vitamin D compound has been stored for a prolonged time. Other typesof processes that can lead to a partial decomposition of vitamin Dcompounds consist of some water-elimination reactions. The driving forcefor these reactions is the allylic (1α-) and homoallylic (3β-) positionof the hydroxy groups. The presence of such above-mentioned oxidationand elimination products can be easily detected by thin-layerchromatography.

Usually, all 1α-hydroxylatation procedures require at least onechromatographic purification. However, even chromatographically purified1α-hydroxyvitamin D compounds, although showing consistent spectroscopicdata that suggests homogeneity, do not meet the purity criteria requiredfor therapeutic agents that can be orally, parenterally or transdermallyadministered. Therefore, it is evident that a suitable method ofpurification of the 1α-hydroxylated vitamin D compounds MET-1 and MET-2is required.

SUMMARY

Disclosed are methods of purifying MET-1 and MET-2 by means ofcrystallization to obtain MET-1 and MET-2 in crystalline form. Thesolvent plays an important role in the crystallization process, and istypically an individual liquid substance or a suitable mixture ofdifferent liquids. For crystallizing MET-1 and MET-2, the mostappropriate solvent and/or solvent system is characterized by thefollowing factors:

-   -   (1) low toxicity;    -   (2) low boiling point;    -   (3) significant dependence of solubility properties with regard        to temperature (condition necessary for providing satisfactory        crystallization yield); and    -   (4) relatively low cost.

Interestingly, hexane, so frequently used for crystallization purposes,was found less suitable as the sole solvent for crystallization of MET-1and MET-2. However, it was found that diethyl ether (Et₂O) was mostuseful for the crystallization of MET-1, and a mixture of 2-propanol andhexane, was most useful for the crystallization of MET-2. In particular,it was determined that a mixture of about 10% to about 20% 2-propanolwith about 90% to about 80% hexane by volume, (preferably 15% 2-propanolwith about 85% hexane by volume) performed well. The diethyl ethersolvent and the 2-propanol/hexane solvent mixture both were easy toremove by evaporation or other well-known methods. In all cases thecrystallization process occurred easily and efficiently. Theprecipitated crystals were sufficiently large to assure their recoveryby filtration or other means, and thus were suitable for x-ray analysis.

Accordingly, disclosed is a compound having the formula:

in crystalline form, where the wavy line at carbon 20 indicates themethyl group attached to carbon 20 may be in its R or S orientation.More specifically, disclosed are(20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ incrystalline form (otherwise referred to as “MET-1”), and(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ incrystalline form, (otherwise referred to as “MET-2”).

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is an illustration of the three dimensional molecular structurefor MET-1 as defined by the atomic positional parameters discovered andset forth herein.

FIG. 2 is an illustration of the three dimensional molecular structurefor MET-2 as defined by the atomic positional parameters discovered andset forth herein.

DETAILED DESCRIPTION

Disclosed herein is(20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 (MET-1)in crystalline form, which is a pharmacologically important compoundcharacterized by the formula I shown below:

Also disclosed herein is(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 (MET-2)in crystalline form, which also is a pharmacologically importantcompound characterized by the formula II shown below:

Also disclosed herein are methods of purifying MET-1 and MET-2. Thepurification technique typically involves obtaining the MET-1 and MET-2products in crystalline form by utilizing a crystallization procedurewherein the material to be purified is dissolved using as the solventeither diethyl ether (Et₂O) as the sole solvent to obtain MET-1, or amixture comprised of 2-propanol and hexane to obtain MET-2. Inparticular, it was determined that a mixture of about 10% to about 20%2-propanol (v/v) with about 90% to about 80% hexane (v/v) performedwell. Preferably the mixture comprises about 15% 2-propanol (v/v) andabout 85% hexane (v/v). Thereafter, the solvent can be removed byevaporation, with or without vacuum, or other means as is well-known inthe art. Alternatively, the resultant crystals may be filtered from themother liquor. The technique can be used to purify a wide range of finalproducts containing MET-1 and MET-2 obtained from any known synthesisthereof, and in varying concentrations, which may range from microgramamounts to kilogram amounts. As is well known to those skilled in thisart, the amount of solvent utilized should be modulated according to theamount of MET-1 and MET-2 to be purified.

EXAMPLES

The following examples are illustrative and should not be interpreted aslimiting the claimed subject matter.

The usefulness and advantages of the present crystallization procedureis shown in the following specific Examples. After crystallization, theprecipitated material was observed under a microscope to confirm itscrystalline form. Yields of crystals were relatively high and theobtained crystals showed a relatively sharp melting point of 99° C.(MET-1) and 154° C. (MET-2).

The described crystallization process of the synthetic MET-1 and MET-2products represents a valuable purification method, which can removemost side products derived from the synthetic path. Such impurity mayresult from contamination of starting raw materials. The crystallizationprocess occurred easily and efficiently. The precipitated crystals weresufficiently large to assure their recovery by filtration, or othermeans, and thus were suitable for x-ray analysis.

Example 1 Crystallization of (20S)-2-methylene-19-nor-22-dimethyl-1α,25dihydroxyvitamin D₃ (MET-1)

Crystallization from Diethyl Ether.

(20 S2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ (MET-1)(14.3 mg), was dissolved in boiling diethyl ether (3 mL) and left atroom temperature for about 1 hour, then it was kept in a refrigeratorfor about 48 hours. The precipitated crystals were filtered off, washedwith a small volume of a cold (0° C.) diethyl ether, and dried to givecrystalline material.

Experimental.

A colorless prism-shaped crystal of dimensions 0.25×0.34×0.55 mm wasselected for structural analysis. Intensity data were collected using aBruker AXS Platinum 135 CCD detector controlled with the PROTEUMsoftware suite (Bruker AXS Inc., Madison, Wis.). The x-ray source wasCuK radiation (1.54178 Å) from a Rigaku RU200 x-ray generator equippedwith Montel optics, operated at 50 kV and 90 mA. The x-ray data wereprocessed with SAINT version 7.06A (Broker AXS Inc.) and internallyscaled with SADABS version 2005/1 (Broker AXS Inc.). The sample wasmounted on a glass fiber using vacuum grease and cooled to 100 K. Theintensity data were measured as a series of phi and omega oscillationframes each of 1° for 10-25 sec/frame. The detector was operated in1024×1024 mode and was positioned 4.5 cm from the sample. Cellparameters were determined from a non-linear least squares fit of 3265peaks in the range of 4.0<theta<55°. The data were merged to form a setof 4624 independent data with R(int)=0.0287.

The monoclinic space group P2(1) was determined by systematic absencesand statistical tests and verified by subsequent refinement. Thestructure was solved by direct methods and refined by full-matrixleast-squares methods on F², (a) G. M. Sheldrick (1994), SHELXTL Version5 Reference Manual, Broker AXS Inc.; (b) International Tables forCrystallography, Vol. C, Kluwer: Boston (1995). Hydrogen atom positionswere determined from difference peaks and ultimately refined by a ridingmodel with idealized geometry. Non-hydrogen atoms were refined withanisotropic displacement parameters. In addition to the molecule ofMET-1, one molecule of diethyl ether was present in the asymmetric unitof the crystalline lattice. A total of 334 parameters were refinedagainst 1 restraint and 4624 data to give wR2=0.0995 and S=1.040 forweights of w=1/[s²(F²) (0.0675P)²], where P=[F_(o) ²+2F_(c) ²]/3. Thefinal R(F) was 0.0332 for the 4624 observed data. The largest shift/s.u.was 0.001 in the final refinement cycle and the final difference map hadmaxima and minima of 0.238 and −0.201 e/Å³, respectively. The absolutestructure was determined by refinement of the Flack parameter, H. D.Flack, Acta Cryst. A, vol. 39, 876-881 (1983).

The three dimensional structure of MET-1 as defined by the followingphysical data and atomic positional parameters described and calculatedherein (Tables 1-8) is illustrated in FIG. 1.

Example 2 Crystallization of(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ (MET-2)

Crystallization from 2-propanol/hexane.

(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ (22.7mg), was suspended in hexane (4 mL) and then 2-propanol was addeddropwise to the suspension. The mixture was heated in a water bath todissolve the vitamin, then was left at room temperature for about 1hour, and finally was kept in a refrigerator for about 48 hours. Theprecipitated crystals were filtered off, washed with a small volume of acold (0° C.) 2-propanol/hexane (3:1) mixture, and dried to givecrystalline material. It should be noted that an excess of 2-propanolshould be avoided to get the point of saturation, i.e. only about 1 moleor less of 2-propanol should be added.

Experimental.

A colorless prism-shaped crystal of dimensions 0.36×0.17×0.03 mm wasselected for structural analysis. Intensity data were collected using aBruker AXS Platinum 135 CCD detector controlled with the PROTEUMsoftware suite (Bruker AXS Inc., Madison, Wis.). The x-ray source wasCuK radiation (1.54178 Å) from a Rigaku RU200 x-ray generator equippedwith Montel optics, operated at 50 kV and 90 mA. The x-ray data wereprocessed with SAINT version 7.06A (Bruker AXS Inc.) and internallyscaled with SADABS version 2005/1 (Bruker AXS Inc.). The sample wasmounted in a quartz capillary tube and data collected at 298 K. Theintensity data were measured as a series of phi and omega oscillationframes each of 1° for 20-40 sec/frame. The detector was operated in1024×1024 mode and was positioned 4.5 cm from the sample. Cellparameters were determined from a non-linear least squares fit of 9999peaks in the range of 2.51<theta<58.69°. The data were merged to form aset of 3985 independent data with R(int)=0.0473.

The monoclinic space group C2 was determined by systematic absences andstatistical tests and verified by subsequent refinement. The structurewas solved by direct methods and refined by full-matrix least-squaresmethods on F², (a) G. M. Sheldrick (1994), SHELXTL Version 5 ReferenceManual, Bruker AXS Inc.; (b) International Tables for Crystallography,Vol. C, Kluwer: Boston (1995). Hydrogen atom positions were determinedfrom difference peaks and ultimately refined by a riding model withidealized geometry. Non-hydrogen atoms were refined with anisotropicdisplacement parameters. In addition to the molecule of MET-2, onemolecule of isopropanol was present in the asymmetric unit of thecrystalline lattice. A total of 325 parameters were refined against 1restraint and 3985 data to give wR2=0.1600 and S=1.073 for weights ofw=1/[s²(F²)+(0.1033P)²], where P=[F_(o) ²+2F_(c) ²]/3. The final R(F)was 0.0844 for the 3985 observed data. The largest shift/s.u. was 0.001in the final refinement cycle and the final difference map had maximaand minima of 0.140 and −0.190 e/Å³, respectively. The absolutestructure was determined by refinement of the Flack parameter, H. D.Flack, Acta Cryst. A, vol. 39, 876-881 (1983).

The three dimensional structure of MET-2 as defined by the followingphysical data and atomic positional parameters described and calculatedherein (Tables 9-16) is illustrated in FIG. 2.

TABLE 1 Crystal data and structure refinement for MET-1. Empiricalformula C33H58O4 Formula weight 518.79 Temperature 100(1) K Wavelength1.54178 Å Crystal system, space group Monoclinic, P2(1) Unit celldimensions a = 7.5780(15)Å α = 90° b = 14.792(3) Å β = 102.22(3)° c =14.481(3) Å γ = 90° Volume 1586.5(6) Å³ Z 2 Calculated density 1.086Mg/m³ Absorption coefficient 0.532 mm⁻¹ F(000) 576 Crystal size 0.25 ×0.34 × 0.55 mm Theta range for data collection 3.12 to 63.06° Limitingindices −8 <= h <= 8, −17 <= k <= 16, 0 <= l <= 16 Reflectionscollected/unique 7564/4624 [R(int) = 0.0287] Data/restraints/parameters4624/1/334 Goodness-of-fit on F² 1.040 Final R indices [I > 2□(I)] R1 =0.0330, wR2 = 0.0955 R indices (all data) R1 = 0.0332, wR2 = 0.0959Absolute structure parameter −0.01(15) Largest diff. peak and hole 0.238and −0.201 e/Å³

TABLE 2 Atomic coordinates (Å² × 10⁴) and equivalent isotropicdisplacement parameters (Å² × 10³) for MET-1 U(eq) is defined as onethird of the trace of the orthogonalized Uij tensor. x y z U(eq) O(3)−1435(2) 3847(1) 11389(1) 26(1) O(100) −1576(2) 5643(1) 10959(1) 32(1)O(25) −4404(2) −6333(1) 12194(1) 27(1) O(1) 3382(2) 2361(1) 11284(1)28(1) C(5) −1471(2) 1831(1) 11117(1) 22(1) C(13) −3621(2) −1411(1)13186(1) 22(1) C(6) −2465(2) 1391(1) 11638(1) 23(1) C(20) −3217(2)−3144(1) 13759(1) 23(1) C(14) −2234(2) −617(1) 13380(1) 23(1) C(2)716(2) 3237(1) 10539(1) 24(1) C(22) −2071(2) −3839(1) 14466(1) 27(1)C(7) −1882(2) 618(1) 12255(1) 23(1) C(4) −2313(2) 2542(1) 10414(1) 24(1)C(8) −2850(2) 217(1) 12818(1) 24(1) C(23) −2980(2) −4791(1) 14332(1)28(1) C(3) −1246(2) 3423(1) 10520(1) 25(1) C(21) −5206(2) −3181(1)13826(1) 30(1) C(24) −3359(2) −5161(1) 13320(1) 27(1) C(1) 1560(2)2561(1) 11290(1) 23(1) C(10) 502(2) 1670(1) 11152(1) 22(1) C(15) −456(2)−1058(1) 13319(1) 26(1) C(12) −5392(2) −1054(1) 13413(1) 28(1) C(9)−4631(2) 555(1) 12982(1) 29(1) C(17) −2546(2) −2145(1) 13863(1) 22(1)C(101) −280(3) 6264(1) 11455(1) 40(1) C(29) 1591(3) 3619(1) 9940(1)31(1) C(30) −125(2) −3978(1) 14326(1) 31(1) C(16) −580(2) −2012(1)13723(1) 25(1) C(18) −3930(2) −1723(1) 12152(1) 24(1) C(11) −6056(2)−197(1) 12851(1) 29(1) C(25) −3972(3) −6149(1) 13189(1) 31(1) C(201)−3380(3) 6000(1) 10736(1) 38(1) C(27) −2516(4) −6804(2) 13656(2) 65(1)C(28) −1941(3) −3553(1) 15498(1) 35(1) C(202) −4591(3) 5306(2) 10178(2)48(1) C(26) −5726(3) −6301(2) 13518(1) 50(1) C(102) 1535(3) 5832(2)11596(2) 54(1)

TABLE 3 Bond lengths [Å] for MET-1. O(3)—C(3) 1.440(2) O(100)—C(101)1.423(2) O(100)—C(201) 1.437(2) O(25)—C(25) 1.435(2) O(1)—C(1)1.4140(19) C(5)—C(6) 1.342(2) C(5)—C(10) 1.504(2) C(5)—C(4) 1.508(2)C(13)—C(18) 1.537(2) C(13)—C(12) 1.542(2) C(13)—C(14) 1.561(2)C(13)—C(17) 1.570(2) C(6)—C(7) 1.461(2) C(20)—C(21) 1.532(2) C(20)—C(17)1.559(2) C(20)—C(22) 1.575(2) C(14)—C(8) 1.497(2) C(14)—C(15) 1.516(2)C(2)—C(29) 1.325(2) C(2)—C(3) 1.506(2) C(2)—C(1) 1.516(2) C(22)—C(28)1.536(2) C(22)—C(30) 1.544(2) C(22)—C(23) 1.562(2) C(7)—C(8) 1.345(2)C(4)—C(3) 1.524(2) C(8)—C(9) 1.505(2) C(23)—C(24) 1.533(2) C(24)—C(25)1.532(2) C(1)—C(10) 1.533(2) C(15)—C(16) 1.539(2) C(12)—C(11) 1.532(2)C(9)—C(11) 1.534(2) C(17)—C(16) 1.558(2) C(101)—C(102) 1.491(3)C(25)—C(27) 1.516(3) C(25)—C(26) 1.521(3) C(201)—C(202) 1.495(3)

TABLE 4 Bond angles [°] for MET-1. C(101)—O(100)—C(201) 113.47(15)C(6)—C(5)—C(10) 125.17(14) C(6)—C(5)—C(4) 120.68(15) C(10)—C(5)—C(4)114.14(13) C(18)—C(13)—C(12) 110.52(13) C(18)—C(13)—C(14) 111.04(12)C(12)—C(13)—C(14) 106.64(13) C(18)—C(13)—C(17) 110.70(13)C(12)—C(13)—C(17) 117.67(13) C(14)—C(13)—C(17) 99.63(12) C(5)—C(6)—C(7)126.18(15) C(21)—C(20)—C(17) 109.44(13) C(21)—C(20)—C(22) 110.45(13)C(17)—C(20)—C(22) 115.60(13) C(8)—C(14)—C(15) 120.05(14)C(8)—C(14)—C(13) 113.68(13) C(15)—C(14)—C(13) 103.82(13) C(29)—C(2)—C(3)122.61(16) C(29)—C(2)—C(1) 123.89(16) C(3)—C(2)—C(1) 113.49(13)C(28)—C(22)—C(30) 107.31(14) C(28)—C(22)—C(23) 107.77(13)C(30)—C(22)—C(23) 105.76(14) C(28)—C(22)—C(20) 111.43(14)C(30)—C(22)—C(20) 114.34(13) C(23)—C(22)—C(20) 109.89(13) C(8)—C(7)—C(6)125.67(15) C(5)—C(4)—C(3) 112.89(14) C(7)—C(8)—C(14) 123.11(15)C(7)—C(8)—C(9) 124.84(15) C(14)—C(8)—C(9) 112.04(14) C(24)—C(23)—C(22)115.43(13) O(3)—C(3)—C(2) 110.16(13) O(3)—C(3)—C(4) 108.15(12)C(2)—C(3)—C(4) 110.21(13) C(25)—C(24)—C(23) 116.71(14) O(1)—C(1)—C(2)113.40(13) O(1)—C(1)—C(10) 107.71(12) C(2)—C(1)—C(10) 110.12(13)C(5)—C(10)—C(1) 110.88(13) C(14)—C(15)—C(16) 104.17(13)C(11)—C(12)—C(13) 111.93(13) C(8)—C(9)—C(11) 111.72(14)C(20)—C(17)—C(16) 114.06(13) C(20)—C(17)—C(13) 118.64(13)C(16)—C(17)—C(13) 102.46(12) O(100)—C(101)—C(102) 108.10(16)C(15)—C(16)—C(17) 107.60(13) C(12)—C(11)—C(9) 113.01(14)O(25)—C(25)—C(27) 108.39(16) O(25)—C(25)—C(26) 104.95(14)C(27)—C(25)—C(26) 111.5(2) O(25)—C(25)—C(24) 107.75(13)C(27)—C(25)—C(24) 112.43(16) C(26)—C(25)—C(24) 111.40(16)O(100)—C(201)—C(202) 108.38(16)

TABLE 5 Anisotropic displacement parameters (Å² × 10³) for MET-1. Theanisotropic displacement factor exponent takes the form: −2π²[h²a *²U₁₁ + . . . + 2hka * b * U₁₂. U₁₁ U₂₂ U₃₃ U₂₃ U₁₃ U₁₂ O(3) 26(1) 17(1)37(1) 0(1) 10(1) 1(1) O(100) 40(1) 19(1) 37(1) 2(1) 9(1) 3(1) O(25)28(1) 28(1) 26(1) −2(1) 6(1) −7(1) O(1) 17(1) 23(1) 44(1) −6(1) 8(1)−2(1) C(5) 21(1) 16(1) 27(1) −4(1) 4(1) −2(1) C(13) 23(1) 21(1) 24(1)0(1) 8(1) −2(1) C(6) 19(1) 18(1) 32(1) −2(1) 6(1) 0(1) C(20) 28(1) 20(1)23(1) 1(1) 8(1) −5(1) C(14) 25(1) 20(1) 25(1) −2(1) 6(1) −3(1) C(2)27(1) 17(1) 29(1) −5(1) 7(1) −4(1) C(22) 33(1) 22(1) 24(1) 3(1) 4(1)−6(1) C(7) 19(1) 18(1) 30(1) −2(1) 6(1) −1(1) C(4) 21(1) 21(1) 30(1)1(1) 3(1) 1(1) C(8) 25(1) 18(1) 29(1) −3(1) 6(1) −1(1) C(23) 38(1) 21(1)25(1) 3(1) 6(1) −5(1) C(3) 29(1) 20(1) 28(1) 4(1) 7(1) 2(1) C(21) 29(1)23(1) 39(1) 2(1) 11(1) −6(1) C(24) 34(1) 22(1) 24(1) 2(1) 6(1) −4(1)C(1) 20(1) 22(1) 29(1) −2(1) 8(1) 0(1) C(10) 21(1) 20(1) 27(1) 2(1) 7(1)2(1) C(15) 20(1) 23(1) 33(1) 3(1) 4(1) −3(1) C(12) 29(1) 24(1) 34(1)1(1) 14(1) −2(1) C(9) 30(1) 24(1) 38(1) 2(1) 16(1) 4(1) C(17) 25(1)20(1) 20(1) 0(1) 6(1) −4(1) C(101) 65(1) 25(1) 29(1) −1(1) 10(1) −9(1)C(29) 33(1) 24(1) 39(1) 3(1) 13(1) −2(1) C(30) 33(1) 23(1) 36(1) 9(1)1(1) −1(1) C(16) 22(1) 21(1) 29(1) 2(1) 1(1) −2(1) C(18) 25(1) 20(1)26(1) 0(1) 4(1) −1(1) C(11) 25(1) 28(1) 39(1) 3(1) 16(1) 3(1) C(25)42(1) 23(1) 25(1) 2(1) 1(1) −6(1) C(201) 48(1) 28(1) 44(1) 11(1) 22(1)15(1) C(27) 93(2) 25(1) 55(1) 0(1) −32(1) 8(1) C(28) 49(1) 29(1) 26(1)2(1) 4(1) −12(1) C(202) 35(1) 46(1) 58(1) 14(1) 2(1) 13(1) C(26) 75(2)50(1) 31(1) −7(1) 23(1) −34(1) C(102) 54(1) 41(1) 57(1) 2(1) −10(1)−14(1)

TABLE 6 Hydrogen coordinates (Å² × 10⁴) and isotropic displacementparameters (Å² × 10³) for MET-1. H(3A) −1246 4391 11360 40 H(25A) −3854−5981 11920 41 H(1A) 4033 2763 11559 41 H(6A) −3636 1598 11604 27 H(20F)−3157 −3339 13120 28 H(14A) −2129 −451 14045 28 H(7A) −743 383 12258 27H(4A) −3529 2665 10495 29 H(4B) −2398 2310 9780 29 H(23A) −2206 −521714739 34 H(23B) −4112 −4761 14542 34 H(3B) −1735 3823 9988 30 H(21A)−5886 −2755 13392 45 H(21B) −5311 −3033 14458 45 H(21C) −5668 −377913671 45 H(24A) −4282 −4787 12936 40 H(24B) −2270 −5094 13075 40 H(1B)1502 2809 11910 28 H(10F) 646 1386 10569 27 H(10G) 983 1262 11669 27H(15A) 554 −727 13690 31 H(15B) −316 −1087 12669 31 H(12A) −6313 −151813267 33 H(12B) −5200 −923 14084 33 H(9A) −5058 1043 12544 35 H(9B)−4464 795 13618 35 H(17A) −2559 −1957 14511 26 H(10A) −557 6412 12061 48H(10B) −298 6817 11094 48 H(29A) 994 4020 9485 37 H(29B) 2803 3486 997537 H(30A) 485 −4408 14780 47 H(30B) 509 −3412 14411 47 H(30C) −160 −420113700 47 H(16A) 271 −2075 14322 30 H(16B) −299 −2463 13290 30 H(18A)−4591 −1267 11750 35 H(18B) −4607 −2276 12077 35 H(18C) −2787 −182011983 35 H(11A) −7122 26 13048 35 H(11B) −6400 −349 12186 35 H(20A)−3409 6551 10371 46 H(20B) −3782 6139 11313 46 H(27A) −1429 −6689 1343597 H(27B) −2910 −7412 13498 97 H(27C) −2288 −6726 14328 97 H(28A) −1234−3988 15910 53 H(28B) −3130 −3522 15627 53 H(28C) −1377 −2970 15600 53H(20C) −5804 5534 10022 71 H(20D) −4560 4764 10546 71 H(20E) −4187 51759607 71 H(26A) −6077 −6924 13425 75 H(26B) −6654 −5923 13161 75 H(26C)−5554 −6154 14177 75 H(10C) 2433 6241 11927 81 H(10D) 1798 5688 10993 81H(10E) 1544 5288 11958

TABLE 7 Torsion angles [deg] for MET-1. C(10)—C(5)—C(6)—C(7) −6.9(3)C(4)—C(5)—C(6)—C(7) 172.04(14) C(18)—C(13)—C(14)—C(8) 62.64(17)C(12)—C(13)—C(14)—C(8) −57.81(17) C(17)—C(13)—C(14)—C(8) 179.34(12)C(18)—C(13)—C(14)—C(15) −69.49(16) C(12)—C(13)—C(14)—C(15) 170.05(13)C(17)—C(13)—C(14)—C(15) 47.21(14) C(21)—C(20)—C(22)—C(28) −68.60(17)C(17)—C(20)—C(22)—C(28) 56.32(18) C(21)—C(20)—C(22)—C(30) 169.50(14)C(17)—C(20)—C(22)—C(30) −65.58(18) C(21)—C(20)—C(22)—C(23) 50.77(17)C(17)—C(20)—C(22)—C(23) 175.69(13) C(5)—C(6)—C(7)—C(8) 175.69(16)C(6)—C(5)—C(4)—C(3) 129.93(16) C(10)—C(5)—C(4)—C(3) −50.98(18)C(6)—C(7)—C(8)—C(14) 175.28(14) C(6)—C(7)—C(8)—C(9) −6.4(3)C(15)—C(14)—C(8)—C(7) −0.9(2) C(13)—C(14)—C(8)—C(7) −124.65(17)C(15)—C(14)—C(8)—C(9) −179.41(15) C(13)—C(14)—C(8)—C(9) 56.87(17)C(28)—C(22)—C(23)—C(24) 175.53(15) C(30)—C(22)—C(23)—C(24) −69.94(18)C(20)—C(22)—C(23)—C(24) 53.94(19) C(29)—C(2)—C(3)—O(3) −116.79(17)C(1)—C(2)—C(3)—O(3) 64.38(16) C(29)—C(2)—C(3)—C(4) 123.95(17)C(1)—C(2)—C(3)—C(4) −54.88(17) C(5)—C(4)—C(3)—O(3) −69.91(16)C(5)—C(4)—C(3)—C(2) 50.56(17) C(22)—C(23)—C(24)—C(25) 170.72(15)C(29)—C(2)—C(1)—O(1) −1.0(2) C(3)—C(2)—C(1)—O(1) 177.82(12)C(29)—C(2)—C(1)—C(10) −121.76(17) C(3)—C(2)—C(1)—C(10) 57.05(16)C(6)—C(5)—C(10)—C(1) −128.78(16) C(4)—C(5)—C(10)—C(1) 52.18(17)O(1)—C(1)—C(10)—C(5) −178.02(11) C(2)—C(1)—C(10)—C(5) −53.90(16)C(8)—C(14)—C(15)—C(16) −163.10(13) C(13)—C(14)—C(15)—C(16) −34.78(16)C(18)—C(13)—C(12)—C(11) −65.07(17) C(14)—C(13)—C(12)—C(11) 55.72(17)C(17)—C(13)—C(12)—C(11) 166.45(14) C(7)—C(8)—C(9)—C(11) 130.33(18)C(14)—C(8)—C(9)—C(11) −51.22(17) C(21)—C(20)—C(17)—C(16) −175.23(13)C(22)—C(20)—C(17)—C(16) 59.33(17) C(21)—C(20)—C(17)—C(13) −54.36(17)C(22)—C(20)—C(17)—C(13) −179.80(12) C(18)—C(13)—C(17)—C(20) −50.06(18)C(12)—C(13)—C(17)—C(20) 78.34(18) C(14)—C(13)—C(17)—C(20) −167.02(12)C(18)—C(13)—C(17)—C(16) 76.56(15) C(12)—C(13)—C(17)—C(16) −155.04(14)C(14)—C(13)—C(17)—C(16) −40.40(14) C(201)—O(100)—C(101)—C(102)−177.01(16) C(14)—C(15)—C(16)—C(17) 8.55(16) C(20)—C(17)—C(16)—C(15)150.05(13) C(13)—C(17)—C(16)—C(15) 20.53(16) C(13)—C(12)—C(11)—C(9)−54.82(19) C(8)—C(9)—C(11)—C(12) 50.78(18) C(23)—C(24)—C(25)—O(25)175.01(14) C(23)—C(24)—C(25)—C(27) −65.6(2) C(23)—C(24)—C(25)—C(26)60.4(2) C(101)—O(100)—C(201)—C(202) 177.20(15)

TABLE 8 Observed and calculated structure factors for MET-1. h k l 10Fo10Fc 10s h k l 10Fo 10Fc 10s h k l 10Fo 10Fc 10s h k l 10Fo 10Fc 10s h kl 10Fo 10Fc 10s 0 −16 0 150 149 2 1 2 0 479 489 5 2 15 0 41 44 1 3 −9 137 37 1 4 1 1 139 136 2 1 −16 0 52 52 1 2 2 0 217 210 2 3 15 0 34 36 1 4−9 1 188 187 3 5 1 1 75 72 1 2 −16 0 77 74 1 3 2 0 118 120 1 4 15 0 9595 1 5 −9 1 192 181 3 6 1 1 131 124 2 3 −16 0 134 137 2 4 2 0 253 245 32 16 0 76 74 1 6 −9 1 3 6 3 7 1 1 154 157 2 1 −15 0 106 109 1 5 2 0 5651 1 0 −17 1 74 72 1 −6 −8 1 25 23 1 8 1 1 21 20 1 2 −15 0 44 45 1 6 2 0195 199 3 −3 −16 1 41 39 1 −5 −8 1 142 141 2 −8 2 1 47 49 1 3 −15 0 3436 1 7 2 0 79 74 1 −2 −16 1 75 77 1 −4 −8 1 24 21 1 −7 2 1 143 145 2 4−15 0 91 94 1 8 2 0 50 49 1 −1 −16 1 5 5 4 −3 −8 1 44 43 1 −6 2 1 40 381 0 −14 0 137 148 1 1 3 0 141 142 1 0 −16 1 51 50 1 −2 −8 1 66 64 1 −5 21 46 49 1 1 −14 0 18 16 1 2 3 0 272 281 3 1 −16 1 167 170 1 −1 −8 1 10398 1 −4 2 1 59 51 1 2 −14 0 98 96 1 3 3 0 252 247 3 2 −16 1 4 6 4 0 −8 1149 161 3 −3 2 1 448 429 5 3 −14 0 110 106 1 4 3 0 55 60 1 −4 −15 1 112113 2 1 −8 1 187 189 2 −2 2 1 146 146 1 4 −14 0 22 21 1 5 3 0 70 68 1 −3−15 1 114 109 1 2 −8 1 160 151 1 −1 2 1 328 333 3 1 −13 0 104 107 1 6 30 151 145 2 −2 −15 1 105 99 1 3 −8 1 88 80 1 0 2 1 275 279 4 2 −13 0 7472 1 7 3 0 72 70 1 −1 −15 1 63 66 1 4 −8 1 203 198 3 1 2 1 372 371 4 3−13 0 102 95 1 8 3 0 30 33 1 0 −15 1 57 53 1 5 −8 1 115 116 2 2 2 1 189195 2 4 −13 0 123 117 2 0 4 0 924 916 22 1 −15 1 39 39 1 6 −8 1 27 27 13 2 1 167 170 2 5 −13 0 41 42 1 1 4 0 319 318 4 2 −15 1 72 73 1 −4 −7 1268 270 5 4 2 1 66 71 1 0 −12 0 43 42 1 2 4 0 399 410 4 3 −15 1 48 46 1−3 −7 1 110 109 1 5 2 1 63 65 1 1 −12 0 76 72 1 3 4 0 250 245 3 −5 −14 157 62 1 −2 −7 1 153 142 1 6 2 1 123 120 2 2 −12 0 67 63 1 4 4 0 87 81 1−4 −14 1 66 72 1 −1 −7 1 391 378 5 7 2 1 130 133 2 3 −12 0 44 40 1 5 4 0153 154 1 −3 −14 1 7 10 3 0 −7 1 185 171 2 8 2 1 56 50 1 4 −12 0 75 86 16 4 0 31 38 1 −2 −14 1 49 45 1 1 −7 1 354 336 4 −8 3 1 22 20 1 5 −12 079 74 1 7 4 0 69 74 1 −1 −14 1 63 65 1 2 −7 1 236 227 2 −7 3 1 101 95 16 −12 0 66 61 1 8 4 0 12 18 1 0 −14 1 34 35 1 3 −7 1 211 209 3 −6 3 1 7474 1 1 −11 0 88 88 1 1 5 0 48 55 1 1 −14 1 83 88 1 −3 −6 1 480 451 5 −53 1 117 119 1 2 −11 0 105 103 1 2 5 0 241 222 3 2 −14 1 31 30 1 −2 −6 1598 575 6 −4 3 1 251 235 3 3 −11 0 158 162 1 3 5 0 163 165 2 3 −14 1 108 2 −1 −6 1 152 146 1 −3 3 1 143 128 1 4 −11 0 50 52 1 4 5 0 158 167 1 4−14 1 26 28 1 0 −6 1 303 302 4 −2 3 1 191 189 2 5 −11 0 133 130 2 5 5 089 87 1 −5 −13 1 125 128 2 1 −6 1 562 533 6 −1 3 1 406 413 6 6 −11 0 1822 1 6 5 0 192 193 3 −4 −13 1 41 41 1 2 −6 1 254 234 2 0 3 1 293 280 5 0−10 0 186 194 1 7 5 0 43 42 1 −3 −13 1 76 76 1 −3 −5 1 126 122 3 1 3 1364 373 4 1 −10 0 65 57 1 8 5 0 35 37 1 −2 −13 1 57 52 1 −2 −5 1 54 55 12 3 1 242 241 2 2 −10 0 167 171 1 0 6 0 382 366 8 −1 −13 1 137 144 1 −1−5 1 358 351 3 3 3 1 275 287 5 3 −10 0 238 244 1 1 6 0 453 436 8 0 −13 191 97 1 0 −5 1 275 275 2 4 3 1 137 135 1 4 −10 0 158 152 2 3 6 0 312 3094 1 −13 1 193 196 1 1 −5 1 58 66 1 5 3 1 36 39 1 5 −10 0 96 90 1 4 6 0232 222 1 2 −13 1 199 205 1 2 −5 1 37 36 1 6 3 1 134 135 2 6 −10 0 92 921 5 6 0 158 155 1 3 −13 1 82 85 1 −3 −4 1 406 386 10 7 3 1 84 81 1 1 −90 185 185 1 6 6 0 170 175 2 4 −13 1 29 27 1 −2 −4 1 198 185 2 8 3 1 4544 1 2 −9 0 171 177 1 7 6 0 138 133 2 5 −13 1 23 21 1 −1 −4 1 367 368 3−8 4 1 37 38 1 3 −9 0 86 87 1 8 6 0 57 61 1 −6 −12 1 40 39 1 0 −4 1 229233 1 −7 4 1 113 118 2 4 −9 0 185 178 3 1 7 0 256 225 4 −5 −12 1 80 74 11 −4 1 508 500 5 −6 4 1 116 116 2 5 −9 0 128 130 2 2 7 0 113 122 3 −4−12 1 88 92 1 2 −4 1 242 228 2 −5 4 1 108 109 1 6 −9 0 53 55 1 3 7 0 8795 1 −3 −12 1 64 66 1 −3 −3 1 146 127 3 −4 4 1 69 60 1 0 −8 0 262 252 64 7 0 119 119 1 −2 −12 1 170 176 1 −2 −3 1 189 189 2 −3 4 1 402 384 6 1−8 0 168 164 2 5 7 0 180 184 1 −1 −12 1 151 147 1 −1 −3 1 403 412 4 −2 41 191 185 2 2 −8 0 44 41 1 6 7 0 25 23 1 0 −12 1 147 146 1 0 −3 1 289281 2 −1 4 1 365 367 4 3 −8 0 155 149 1 7 7 0 73 73 1 1 −12 1 39 40 1 1−3 1 377 373 3 0 4 1 227 233 4 4 −8 0 232 231 4 0 8 0 267 253 6 2 −12 1125 128 1 2 −3 1 240 242 2 1 4 1 504 501 8 5 −8 0 120 115 2 1 8 0 170164 4 3 −12 1 93 94 1 −2 −2 1 142 145 1 2 4 1 236 228 2 6 −8 0 88 85 1 28 0 41 41 1 4 −12 1 30 34 1 −1 −2 1 330 333 3 3 4 1 315 294 4 1 −7 0 254225 3 3 8 0 154 150 1 5 −12 1 40 35 1 0 −2 1 274 279 2 4 4 1 235 230 2 2−7 0 120 123 1 4 8 0 231 231 2 −6 −11 1 81 84 1 1 −2 1 375 372 3 5 4 1243 242 1 3 −7 0 89 96 1 5 8 0 118 115 1 −5 −11 1 66 65 1 2 −2 1 186 1964 6 4 1 79 80 1 0 −6 0 346 368 9 6 8 0 87 85 1 −4 −11 1 36 33 1 −8 −1 123 27 1 7 4 1 48 50 1 1 −6 0 458 436 4 7 8 0 56 57 1 −3 −11 1 10 12 1 −7−1 1 107 107 1 8 4 1 53 57 1 2 −6 0 246 233 2 1 9 0 180 185 3 −2 −11 1113 112 1 −2 −1 1 44 48 1 −8 5 1 75 75 1 3 −6 0 318 309 7 2 9 0 171 1762 −1 −11 1 122 122 1 −1 −1 1 228 240 2 −7 5 1 131 135 2 1 −5 0 47 53 1 39 0 87 88 1 0 −11 1 120 110 1 0 −1 1 99 95 1 −6 5 1 218 238 2 2 −5 0 247222 2 4 9 0 186 178 2 1 −11 1 138 138 1 1 −1 1 339 344 3 −5 5 1 131 1201 3 −5 0 168 164 4 5 9 0 129 130 1 2 −11 1 268 266 2 2 −1 1 364 386 9 −45 1 106 117 1 0 −4 0 922 916 10 6 9 0 50 55 1 3 −11 1 126 119 1 7 −1 1151 157 2 −3 5 1 129 121 2 1 −4 0 324 317 3 1 10 0 66 57 1 4 −11 1 163163 2 −8 0 1 6 0 3 −2 5 1 53 56 1 2 −4 0 405 410 4 2 10 0 168 171 2 5−11 1 35 36 1 −7 0 1 63 70 1 −1 5 1 357 351 4 1 −3 0 141 141 1 3 10 0237 243 2 6 −11 1 31 32 1 −6 0 1 57 60 1 0 5 1 274 276 4 2 −3 0 269 2802 4 10 0 154 152 1 −6 −10 1 83 81 1 −3 0 1 226 236 3 1 5 1 57 67 1 0 −20 115 113 2 5 10 0 96 90 1 −5 −10 1 166 167 3 −2 0 1 5 9 5 2 5 1 38 37 11 −2 0 485 488 5 6 10 0 91 93 1 −4 −10 1 217 215 3 −1 0 1 526 532 5 3 51 288 270 4 2 −2 0 217 210 5 1 11 0 90 90 1 −3 −10 1 214 216 1 0 0 1 128131 1 4 5 1 266 273 2 1 −1 0 460 471 11 2 11 0 105 103 2 −2 −10 1 169175 1 1 0 1 1440 1454 16 5 5 1 303 307 2 2 −1 0 239 259 6 3 11 0 157 1622 −1 −10 1 136 145 1 2 0 1 78 75 1 6 5 1 46 52 1 7 −1 0 120 126 2 4 11 050 52 1 0 −10 1 287 290 1 3 0 1 393 391 6 7 5 1 92 93 1 1 0 0 86 93 1 511 0 133 130 1 1 −10 1 188 180 1 6 0 1 101 102 1 8 5 1 23 28 1 2 0 0 181158 2 6 11 0 19 22 1 2 −10 1 145 142 1 7 0 1 61 65 1 −8 6 1 61 65 1 3 00 173 170 4 3 12 0 44 40 1 3 −10 1 91 93 1 8 0 1 57 56 1 −7 6 1 27 30 16 0 0 105 106 1 4 12 0 79 86 1 4 −10 1 119 109 2 −8 1 1 24 27 1 −6 6 1112 110 1 7 0 0 25 20 1 5 12 0 79 75 1 5 −10 1 67 70 1 −7 1 1 110 107 1−5 6 1 243 241 3 8 0 0 30 34 1 6 12 0 65 62 1 6 −10 1 42 43 1 −6 1 1 6358 1 −4 6 1 77 84 1 1 1 0 467 471 5 1 13 0 107 107 2 −6 −9 1 32 35 1 −51 1 25 23 1 −3 6 1 484 451 11 2 1 0 253 258 2 2 13 0 77 73 1 −5 −9 1 111105 2 −4 1 1 311 301 5 −2 6 1 552 575 15 3 1 0 275 267 5 3 13 0 102 95 1−4 −9 1 22 25 1 −3 1 1 570 528 6 −1 6 1 151 146 2 4 1 0 406 383 7 4 13 0125 117 1 −3 −9 1 123 121 1 −2 1 1 46 49 1 0 6 1 309 301 5 5 1 0 126 1272 5 13 0 41 42 1 −2 −9 1 98 101 1 −1 1 1 230 240 2 1 6 1 560 533 9 6 1 0218 223 3 1 14 0 21 17 2 −1 −9 1 28 17 1 0 1 1 95 94 1 2 6 1 243 234 6 71 0 121 126 2 2 14 0 100 96 2 0 −9 1 349 341 2 1 1 1 325 343 6 3 6 1 4456 1 8 1 0 26 24 1 3 14 0 113 106 1 1 −9 1 96 94 1 2 1 1 372 386 4 4 6 1178 179 1 0 2 0 115 112 3 4 14 0 25 21 1 2 −9 1 59 51 1 3 1 1 248 249 35 6 1 100 100 1 6 6 1 178 184 3 −3 14 1 11 9 2 −7 −9 2 46 48 1 3 0 2 6271 1 −7 6 2 29 26 1 7 6 1 61 60 1 −2 14 1 49 45 1 −6 −9 2 62 62 1 6 0 288 96 1 −6 6 2 107 103 1 −7 7 1 13 13 1 1 14 1 86 88 2 −5 −9 2 30 26 1 70 2 77 80 1 −5 6 2 99 101 1 −6 7 1 80 84 1 2 14 1 33 30 1 −4 −9 2 210206 3 8 0 2 25 23 1 −4 6 2 232 229 1 −5 7 1 233 226 2 3 14 1 10 9 2 −3−9 2 100 97 1 −8 1 2 15 15 1 −3 6 2 247 241 6 −4 7 1 275 271 2 4 14 1 2929 1 −2 −9 2 136 142 1 −7 1 2 152 155 2 −2 6 2 380 388 10 −3 7 1 109 1091 −4 15 1 116 113 2 −1 −9 2 156 157 1 −6 1 2 106 102 1 −1 6 2 213 187 3−2 7 1 148 142 4 −3 15 1 117 109 1 0 −9 2 97 107 1 −5 1 2 133 137 2 0 62 193 179 4 −1 7 1 393 379 6 −2 15 1 104 99 1 1 −9 2 165 164 1 −4 1 2163 167 2 1 6 2 273 253 5 0 7 1 189 170 3 2 15 1 73 74 1 2 −9 2 273 2742 −3 1 2 497 473 5 3 6 2 130 136 1 1 7 1 350 336 9 3 15 1 49 46 1 3 −9 261 61 1 −2 1 2 212 218 2 4 6 2 263 274 2 2 7 1 234 227 6 −3 16 1 42 39 14 −9 2 174 169 3 −1 1 2 664 676 7 5 6 2 107 98 1 3 7 1 212 208 2 −2 16 175 77 1 5 −9 2 111 109 2 0 1 2 1028 1060 13 6 6 2 71 75 1 4 7 1 109 1081 2 16 1 9 6 2 6 −9 2 57 54 1 1 1 2 470 471 5 7 6 2 27 33 1 5 7 1 119122 1 −3 −16 2 5 2 5 −6 −8 2 55 56 1 2 1 2 101 101 1 −7 7 2 80 80 1 6 71 87 89 1 −2 −16 2 101 95 1 −5 −8 2 211 206 3 3 1 2 115 109 1 −6 7 2 10297 1 7 7 1 23 22 1 −1 −16 2 96 93 1 −4 −8 2 61 65 1 4 1 2 96 103 1 −5 72 136 141 1 −7 8 1 30 28 1 0 −16 2 59 57 1 −3 −8 2 122 111 1 5 1 2 64 651 −4 7 2 131 128 1 −6 8 1 25 23 1 1 −16 2 39 37 1 −2 −8 2 181 189 1 6 12 23 24 1 −3 7 2 133 133 1 −5 8 1 140 141 1 2 −16 2 29 31 1 −1 −8 2 227225 3 7 1 2 46 44 1 −2 7 2 132 127 4 −4 8 1 25 20 1 −4 −15 2 22 26 1 0−8 2 47 44 2 8 1 2 16 19 1 −1 7 2 160 135 3 −3 8 1 43 43 1 −3 −15 2 153147 1 1 −8 2 177 185 1 −8 2 2 26 24 1 0 7 2 266 257 6 −2 8 1 67 64 1 −2−15 2 75 71 1 2 −8 2 154 153 1 −7 2 2 28 29 1 1 7 2 56 54 2 −1 8 1 10399 3 −1 −15 2 109 111 1 3 −8 2 140 133 2 −6 2 2 168 167 2 3 7 2 216 2111 0 8 1 152 161 3 0 −15 2 119 118 1 4 −8 2 127 131 2 −5 2 2 132 134 1 47 2 184 197 1 1 8 1 182 190 5 1 −15 2 55 53 1 5 −8 2 249 255 4 −4 2 2230 224 2 5 7 2 37 32 1 2 8 1 165 151 2 2 −15 2 27 28 1 6 −8 2 56 53 1−3 2 2 365 363 4 6 7 2 93 91 1 3 8 1 86 79 1 3 −15 2 94 97 1 −6 −7 2 10097 1 −2 2 2 142 150 1 7 7 2 64 63 1 4 8 1 200 197 1 −5 −14 2 64 62 1 −5−7 2 135 141 2 −1 2 2 642 650 8 −7 8 2 54 49 1 5 8 1 116 116 1 −4 −14 2115 114 1 −4 −7 2 131 127 2 0 2 2 581 595 10 −6 8 2 55 56 1 6 8 1 29 281 −3 −14 2 50 50 1 −3 −7 2 133 133 1 1 2 2 169 179 1 −5 8 2 209 206 2 78 1 42 44 1 −2 −14 2 70 71 1 −2 −7 2 133 127 1 2 2 2 349 336 4 −4 8 2 6365 1 −6 9 1 32 35 1 −1 −14 2 48 52 1 −1 −7 2 160 135 2 3 2 2 120 113 1−3 8 2 122 111 1 −5 9 1 111 105 1 0 −14 2 52 50 1 0 −7 2 252 255 3 4 2 2102 107 1 −2 8 2 181 189 2 −4 9 1 23 24 1 1 −14 2 111 116 1 1 −7 2 58 541 5 2 2 195 196 3 −1 8 2 225 224 6 −3 9 1 121 121 1 2 −14 2 45 47 1 2 −72 149 153 1 6 2 2 141 139 2 0 8 2 49 44 3 −2 9 1 96 101 1 3 −14 2 23 231 3 −7 2 214 211 4 7 2 2 79 80 1 2 8 2 146 154 2 −1 9 1 28 17 1 4 −14 246 44 1 4 −7 2 182 198 3 8 2 2 27 24 1 3 8 2 142 133 1 0 9 1 357 341 6−5 −13 2 25 21 1 −3 −6 2 247 241 3 −8 3 2 43 42 1 4 8 2 128 131 1 1 9 199 95 1 −4 −13 2 169 174 3 −2 −6 2 399 389 4 −7 3 2 130 126 2 5 8 2 253255 3 2 9 1 56 51 1 −3 −13 2 87 89 1 −1 −6 2 207 187 2 −6 3 2 181 168 36 8 2 56 53 1 3 9 1 38 37 1 −2 −13 2 234 237 1 0 −6 2 187 178 2 −5 3 2166 161 1 7 8 2 67 68 1 4 9 1 187 187 2 −1 −13 2 94 92 1 1 −6 2 277 2533 −4 3 2 425 403 5 −6 9 2 61 63 1 5 9 1 187 181 1 0 −13 2 97 100 1 2 −62 303 285 3 −3 3 2 152 139 1 −5 9 2 34 27 1 6 9 1 8 6 1 1 −13 2 83 89 1−3 −5 2 127 125 1 −2 3 2 176 184 1 −4 9 2 210 206 2 −6 10 1 86 81 1 2−13 2 129 131 1 −2 −5 2 73 68 1 −1 3 2 512 520 6 −3 9 2 100 97 1 −5 10 1165 166 2 3 −13 2 111 110 1 −1 −5 2 83 81 1 0 3 2 456 458 7 −2 9 2 137143 2 −4 10 1 212 214 2 4 −13 2 116 112 2 0 −5 2 512 508 5 1 3 2 676 6847 −1 9 2 153 157 2 −3 10 1 212 216 2 5 −13 2 76 75 1 1 −5 2 219 202 2 23 2 160 155 2 0 9 2 101 108 2 −2 10 1 172 175 2 −6 −12 2 81 76 1 2 −5 2298 295 3 3 3 2 132 114 1 2 9 2 274 274 4 −1 10 1 134 145 2 −5 −12 2 5050 1 −3 −4 2 143 136 2 4 3 2 117 125 1 3 9 2 61 61 1 1 10 1 186 180 3 −4−12 2 93 90 1 −2 −4 2 186 180 2 5 3 2 83 90 1 4 9 2 170 169 1 3 10 1 9193 1 −3 −12 2 128 127 1 −1 −4 2 314 312 2 6 3 2 175 174 3 5 9 2 106 1091 4 10 1 111 109 1 −2 −12 2 112 118 1 0 −4 2 99 102 1 7 3 2 77 78 1 6 92 56 53 1 5 10 1 68 69 1 −1 −12 2 83 79 1 1 −4 2 795 786 8 8 3 2 22 21 1−6 10 2 97 97 1 6 10 1 42 43 1 0 −12 2 161 166 1 2 −4 2 299 283 3 −8 4 239 36 1 −5 10 2 120 117 2 −6 11 1 81 84 1 1 −12 2 116 112 1 −3 −3 2 146137 2 −7 4 2 51 62 1 −4 10 2 153 163 2 −5 11 1 67 65 1 2 −12 2 23 28 1−2 −3 2 176 184 1 −6 4 2 279 284 4 −3 10 2 31 35 1 −4 11 1 33 32 1 3 −122 92 101 1 −1 −3 2 514 520 5 −5 4 2 113 114 1 −2 10 2 182 185 2 −3 11 112 11 2 4 −12 2 70 68 1 0 −3 2 453 459 4 −4 4 2 99 98 1 −1 10 2 20 14 2−2 11 1 116 111 2 5 −12 2 53 52 1 1 −3 2 693 684 7 −3 4 2 142 136 2 0 102 146 148 4 −1 11 1 118 121 2 −6 −11 2 77 74 1 2 −3 2 159 156 1 −2 4 2191 181 2 1 10 2 203 208 3 2 11 1 263 266 5 −5 −11 2 52 52 1 −3 −2 2 348364 4 −1 4 2 315 313 4 2 10 2 53 51 1 3 11 1 128 118 1 −4 −11 2 20 28 1−2 −2 2 144 150 1 0 4 2 99 103 2 3 10 2 93 91 1 4 11 1 159 163 1 −3 −112 143 140 1 −1 −2 2 644 650 6 1 4 2 774 787 19 4 10 2 63 65 1 5 11 1 3535 1 −2 −11 2 159 158 1 0 −2 2 579 595 5 3 4 2 65 68 1 5 10 2 93 94 1 611 1 33 33 1 −1 −11 2 107 107 1 1 −2 2 170 180 1 4 4 2 96 97 1 6 10 2 7375 1 −6 12 1 38 38 1 0 −11 2 161 161 1 2 −2 2 344 337 3 5 4 2 175 172 1−6 11 2 75 73 1 −5 12 1 78 74 1 1 −11 2 176 181 1 −8 −1 2 14 15 1 6 4 274 80 1 −5 11 2 52 52 1 −4 12 1 92 92 1 2 −11 2 91 94 1 −7 −1 2 149 1552 7 4 2 54 58 1 −4 11 2 26 29 1 −3 12 1 64 65 1 3 −11 2 101 106 1 −3 −12 483 472 5 8 4 2 14 17 1 −3 11 2 140 140 2 −2 12 1 169 176 3 4 −11 2 5458 1 −2 −1 2 215 218 2 −8 5 2 63 61 1 −2 11 2 161 159 2 −1 12 1 151 1473 5 −11 2 10 12 2 −1 −1 2 666 677 7 −7 5 2 52 56 1 −1 11 2 105 106 2 112 1 37 40 1 6 −11 2 40 46 1 0 −1 2 1043 1061 10 −6 5 2 316 313 3 1 11 2178 181 2 2 12 1 123 127 2 −6 −10 2 97 96 1 1 −1 2 471 472 4 −5 5 2 248251 1 2 11 2 90 94 1 3 12 1 92 95 1 −5 −10 2 118 117 2 2 −1 2 99 101 1−4 5 2 70 71 1 3 11 2 104 106 1 4 12 1 34 35 1 −4 −10 2 157 162 2 7 −1 245 44 1 −3 5 2 125 127 2 4 11 2 57 58 1 5 12 1 39 36 1 −3 −10 2 36 36 1−8 0 2 24 24 1 −2 5 2 73 68 2 5 11 2 10 13 2 −5 13 1 129 128 1 −2 −10 2181 185 1 −7 0 2 49 50 1 −1 5 2 83 80 1 −6 12 2 81 76 1 −4 13 1 41 41 1−1 −10 2 22 15 1 −6 0 2 240 262 4 0 5 2 518 509 12 −5 12 2 49 49 1 −3 131 75 76 1 0 −10 2 154 148 1 −4 0 2 543 562 10 1 5 2 214 202 2 −4 12 2 9391 1 1 13 1 191 196 3 1 −10 2 208 209 1 −3 0 2 456 444 5 3 5 2 247 244 3−3 12 2 128 127 1 2 13 1 201 205 3 2 −10 2 56 51 1 −2 0 2 332 332 3 4 52 172 181 1 −2 12 2 115 117 2 3 13 1 82 85 1 3 −10 2 91 91 1 −1 0 2 967976 10 5 5 2 76 68 1 −1 12 2 85 79 2 4 13 1 26 27 1 4 −10 2 63 64 1 0 02 198 202 2 6 5 2 84 101 1 1 12 2 116 113 2 5 13 1 20 20 1 5 −10 2 93 931 1 0 2 282 287 3 7 5 2 0 4 1 2 12 2 21 27 1 −4 14 1 71 72 1 6 −10 2 7375 1 2 0 2 33 49 1 −8 6 2 84 85 1 3 12 2 93 100 1 4 12 2 70 67 1 −5 −103 147 150 2 −2 −2 3 513 511 5 −3 4 3 169 164 2 −2 10 3 79 78 1 5 12 2 5352 1 −4 −10 3 50 55 1 −1 −2 3 621 628 6 −2 4 3 62 70 1 −1 10 3 272 279 4−5 13 2 25 22 1 −3 −10 3 183 194 1 0 −2 3 994 1008 9 −1 4 3 130 134 1 010 3 122 135 2 −4 13 2 175 174 2 −2 −10 3 80 79 1 1 −2 3 465 462 4 0 4 3176 179 3 1 10 3 138 132 2 −3 13 2 86 89 1 −1 −10 3 271 279 1 2 −2 3 160168 1 1 4 3 196 194 2 2 10 3 32 29 1 −2 13 2 236 236 4 0 −10 3 126 135 17 −2 3 92 97 1 2 4 3 328 305 5 3 10 3 222 221 2 −1 13 2 94 92 2 1 −10 3138 132 1 −8 −1 3 10 17 1 3 4 3 55 53 1 4 10 3 69 65 1 1 13 2 80 89 2 2−10 3 29 29 1 −7 −1 3 16 9 1 4 4 3 100 109 1 5 10 3 52 53 1 2 13 2 127131 1 3 −10 3 222 221 4 −6 −1 3 67 65 1 5 4 3 185 186 1 −6 11 3 69 68 13 13 2 114 111 1 4 −10 3 68 64 1 −4 −1 3 327 314 6 6 4 3 59 58 1 −5 11 3111 114 2 4 13 2 118 111 1 5 −10 3 54 52 1 −3 −1 3 60 62 1 7 4 3 37 33 1−4 11 3 99 106 1 5 13 2 76 75 1 6 −10 3 27 24 1 −2 −1 3 475 474 5 −8 5 322 24 1 −3 11 3 251 251 3 −5 14 2 65 62 1 −7 −9 3 44 45 1 −1 −1 3 219224 2 −7 5 3 35 28 1 −2 11 3 140 128 2 −4 14 2 117 114 1 −6 −9 3 132 1302 0 −1 3 807 818 8 −6 5 3 109 104 1 −1 11 3 93 94 2 −3 14 2 51 50 1 −5−9 3 106 104 2 1 −1 3 206 200 2 −5 5 3 207 205 1 1 11 3 239 244 3 1 14 2112 116 2 −4 −9 3 95 97 1 2 −1 3 103 104 1 −4 5 3 75 77 1 2 11 3 155 1622 2 14 2 44 47 1 −3 −9 3 111 103 1 3 −1 3 33 40 1 −3 5 3 200 197 3 3 113 81 82 1 3 14 2 24 23 1 −2 −9 3 103 104 1 6 −1 3 118 120 2 −2 5 3 117111 3 4 11 3 106 104 1 4 14 2 45 44 1 −1 −9 3 153 158 1 7 −1 3 72 74 1−1 5 3 162 158 3 5 11 3 92 88 1 −4 15 2 26 26 1 0 −9 3 185 193 1 −8 0 367 61 1 0 5 3 339 325 5 −6 12 3 52 48 1 −3 15 2 157 147 2 1 −9 3 177 1871 −7 0 3 17 17 1 1 5 3 703 701 12 −5 12 3 30 27 1 −2 15 2 74 71 1 2 −9 3125 114 1 −6 0 3 87 91 1 2 5 3 251 257 4 −4 12 3 119 130 1 1 15 2 56 531 3 −9 3 75 68 1 −5 0 3 68 76 1 3 5 3 81 86 1 −3 12 3 15 7 2 2 15 2 2627 1 4 −9 3 182 179 3 −4 0 3 82 68 1 4 5 3 59 59 1 −2 12 3 162 163 3 315 2 95 97 1 5 −9 3 123 115 2 −3 0 3 510 487 6 5 5 3 104 106 1 −1 12 3128 129 2 −3 16 2 3 2 3 6 −9 3 29 28 1 −2 0 3 41 45 1 5 5 3 102 112 1 112 3 93 96 2 −2 16 2 100 95 1 −7 −8 3 49 46 1 −1 0 3 962 987 10 7 5 3 4041 1 2 12 3 172 173 2 2 16 2 27 30 1 −6 −8 3 79 82 1 0 0 3 544 559 7 −86 3 34 34 1 3 12 3 71 77 1 −2 −16 3 106 98 2 −5 −8 3 34 32 1 1 0 3 293301 3 −7 6 3 28 27 1 4 12 3 39 40 1 −1 −16 3 68 65 1 −4 −8 3 151 152 2 20 3 386 375 4 −6 6 3 250 250 3 5 12 3 49 49 1 0 −16 3 57 54 1 −3 −8 3 6872 1 3 0 3 84 85 1 −5 6 3 217 224 1 −5 13 3 101 99 1 1 −16 3 38 35 1 −2−8 3 172 177 1 5 0 3 179 177 3 −4 6 3 182 188 1 −4 13 3 119 117 2 2 −163 43 45 1 −1 −8 3 79 80 1 6 0 3 133 128 2 −3 6 3 37 32 3 −3 13 3 159 1572 −4 −15 3 124 123 2 0 −8 3 109 99 1 7 0 3 148 158 2 −2 6 3 116 110 3 −213 3 146 153 3 −3 −15 3 102 101 1 1 −8 3 181 172 1 −8 1 3 13 18 1 −1 6 37 8 6 1 13 3 125 127 2 −2 −15 3 97 95 1 2 −8 3 77 77 1 −7 1 3 14 9 1 0 63 311 307 5 2 13 3 134 135 1 −1 −15 3 75 72 1 3 −8 3 18 16 1 −6 1 3 7166 1 1 6 3 279 255 7 3 13 3 98 96 1 0 −15 3 72 73 1 4 −8 3 130 141 2 −51 3 73 76 1 2 6 3 381 377 9 4 13 3 64 61 1 1 −15 3 68 67 1 5 −8 3 138140 2 −4 1 3 333 314 3 3 6 3 51 47 1 −4 14 3 159 149 2 2 −15 3 47 47 1 6−8 3 84 82 1 −3 1 3 60 61 1 4 6 3 178 181 1 −3 14 3 51 47 1 3 −15 3 5253 1 −7 −7 3 85 88 1 −2 1 3 478 474 5 5 6 3 224 219 2 −2 14 3 62 59 1 −5−14 3 57 57 1 −6 −7 3 110 109 2 −1 1 3 222 224 2 6 6 3 84 83 1 1 14 3 912 6 −4 −14 3 154 149 2 −5 −7 3 99 99 2 0 1 3 798 818 10 7 6 3 41 39 1 214 3 18 18 1 −3 −14 3 49 47 1 −4 −7 3 76 80 1 1 1 3 201 198 2 −7 7 3 8788 1 3 14 3 54 54 1 −2 −14 3 61 59 1 −3 −7 3 138 141 1 2 1 3 101 104 1−6 7 3 115 110 1 4 14 3 70 65 1 −1 −14 3 131 131 1 −2 −7 3 235 237 3 3 13 33 41 1 −5 7 3 101 100 1 −4 15 3 124 123 2 0 −14 3 42 36 1 −1 −7 3 5767 1 4 1 3 143 141 1 −4 7 3 76 80 1 −3 15 3 103 101 1 1 −14 3 9 12 1 0−7 3 47 42 1 5 1 3 68 65 1 −3 7 3 136 141 1 −2 15 3 96 96 2 2 −14 3 1418 1 1 −7 3 109 98 1 6 1 3 120 120 2 −2 7 3 236 236 6 1 15 3 67 67 1 3−14 3 52 53 1 2 −7 3 122 112 1 7 1 3 71 73 1 −1 7 3 57 67 1 2 15 3 45 481 4 −14 3 68 65 1 3 −7 3 203 212 3 −8 2 3 17 26 1 0 7 3 48 43 2 3 15 353 53 1 −5 −13 3 97 99 2 4 −7 3 102 104 1 −7 2 3 68 64 1 1 7 3 106 98 3−2 16 3 102 97 1 −4 −13 3 116 117 1 5 −7 3 176 176 3 −6 2 3 31 27 1 2 73 122 112 2 2 16 3 47 46 1 −3 −13 3 156 157 1 6 −7 3 81 84 1 −5 2 3 166176 1 3 7 3 198 211 1 −2 −16 4 48 45 1 −2 −13 3 145 153 1 −7 −6 3 25 271 −4 2 3 61 56 1 4 7 3 102 103 1 −1 −16 4 3 3 2 −1 −13 3 241 249 2 −6 −63 245 250 4 −3 2 3 261 261 3 5 7 3 174 176 1 0 −16 4 94 97 1 0 −13 3 169172 1 −5 −6 3 216 224 4 −2 2 3 511 511 5 6 7 3 83 84 1 1 −16 4 28 29 1 1−13 3 123 127 1 −4 −6 3 181 188 3 −1 2 3 616 629 8 7 7 3 60 61 1 −3 −154 29 29 1 2 −13 3 134 136 1 −3 −6 3 37 32 1 0 2 3 988 1007 12 −6 8 3 7882 1 −2 −15 4 97 95 1 3 −13 3 97 96 1 −2 −6 3 123 111 1 1 2 3 462 462 4−5 8 3 36 32 1 −1 −15 4 109 107 1 4 −13 3 62 61 1 −1 −6 3 13 7 2 2 2 3163 168 2 −4 8 3 149 152 1 0 −15 4 51 53 1 5 −13 3 42 38 1 0 −6 3 300306 4 3 2 3 265 255 3 −3 8 3 68 72 1 1 −15 4 47 45 1 −6 −12 3 54 49 1 1−6 3 284 255 3 4 2 3 74 81 1 −2 8 3 174 177 2 2 −15 4 74 76 1 −5 −12 328 27 1 2 −6 3 385 377 4 5 2 3 162 157 2 −1 8 3 83 79 2 −4 −14 4 59 60 1−4 −12 3 118 128 2 3 −6 3 49 47 1 6 2 3 75 72 1 0 8 3 109 99 2 −3 −14 4102 101 1 −3 −12 3 13 6 1 −3 −5 3 202 197 2 7 2 3 95 96 1 1 8 3 182 1722 −2 −14 4 26 25 1 −2 −12 3 162 163 1 −2 −5 3 124 110 1 −8 3 3 80 77 1 28 3 77 77 1 −1 −14 4 35 39 1 −1 −12 3 128 130 1 −1 −5 3 159 158 1 −7 3 3162 168 2 3 8 3 14 16 1 0 −14 4 99 101 1 0 −12 3 68 67 1 0 −5 3 331 3263 −6 3 3 170 165 3 4 8 3 131 142 1 1 −14 4 42 40 1 1 −12 3 93 96 1 1 −53 718 700 7 −5 3 3 68 60 1 5 8 3 133 140 1 2 −14 4 67 67 1 2 −12 3 172174 1 2 −5 3 257 257 2 −4 3 3 76 78 1 6 8 3 83 82 1 3 −14 4 53 54 1 3−12 3 71 77 1 −3 −4 3 170 164 1 −3 3 3 324 298 4 −6 9 3 131 130 1 4 −144 61 62 1 4 −12 3 39 41 1 −2 −4 3 66 69 1 −2 3 3 100 89 1 −5 9 3 102 1041 −5 −13 4 43 43 1 5 −12 3 50 50 1 −1 −4 3 131 134 1 −1 3 3 400 401 5 −49 3 93 96 1 −4 −13 4 92 94 1 −6 −11 3 70 69 1 0 −4 3 173 179 1 0 3 3 654670 8 −3 9 3 108 103 1 −3 −13 4 123 127 1 −5 −11 3 113 115 2 1 −4 3 198194 2 1 3 3 379 395 4 −2 9 3 107 105 1 −2 −13 4 118 113 1 −4 −11 3 99106 2 2 −4 3 327 304 3 2 3 3 277 272 3 −1 9 3 148 158 2 −1 −13 4 92 94 1−3 −11 3 252 251 2 −7 −3 3 167 168 2 3 3 3 287 285 3 0 9 3 187 194 3 0−13 4 212 225 1 −2 −11 3 137 128 1 −3 −3 3 321 299 3 4 3 3 61 64 1 1 9 3176 188 2 1 −13 4 87 92 1 −1 −11 3 93 94 1 −2 −3 3 103 89 1 5 3 3 148146 2 2 9 3 126 114 1 2 −13 4 125 128 1 0 −11 3 240 240 1 −1 −3 3 397401 3 6 3 3 118 122 2 3 9 3 74 69 1 3 −13 4 42 43 1 1 −11 3 240 246 1 0−3 3 668 670 6 7 3 3 52 49 1 4 9 3 181 179 2 4 −13 4 100 96 2 2 −11 3157 163 1 1 −3 3 388 394 4 −8 4 3 36 39 1 5 9 3 118 115 1 −6 −12 4 61 581 3 −11 3 80 83 1 2 −3 3 275 273 2 −7 4 3 60 67 1 −6 10 3 61 61 1 −5 −124 36 32 1 4 −11 3 105 105 2 −8 −2 3 17 26 1 −6 4 3 134 131 1 −5 10 3 150150 2 −4 −12 4 65 69 1 5 −11 3 92 88 1 −7 −2 3 67 65 1 −5 4 3 194 205 1−4 10 3 48 55 1 −3 −12 4 116 117 1 −6 −10 3 63 61 1 −3 −2 3 261 263 2 −44 3 287 288 2 −3 10 3 182 194 2 −2 −12 4 70 72 1 −1 −12 4 61 55 1 6 −6 439 36 1 7 0 4 41 41 1 −1 6 4 112 103 2 −2 13 4 119 114 2 0 −12 4 59 62 1−7 −5 4 39 43 1 −8 1 4 39 38 1 0 6 4 227 220 4 1 13 4 87 92 2 1 −12 4119 120 1 −6 −5 4 61 60 1 −7 1 4 143 143 2 1 6 4 192 180 5 2 13 4 125128 1 2 −12 4 52 50 1 −5 −5 4 216 214 3 −6 1 4 54 54 1 2 6 4 37 33 1 313 4 45 43 1 3 −12 4 20 20 1 −4 −5 4 57 54 1 −5 1 4 152 146 1 3 6 4 141136 1 4 13 4 100 95 1 4 −12 4 23 23 1 −3 −5 4 135 141 1 −4 1 4 442 419 54 6 4 229 232 1 −4 14 4 61 60 1 5 −12 4 55 51 1 −2 −5 4 419 406 4 −3 1 483 83 1 5 6 4 63 61 1 −3 14 4 103 101 1 −6 −11 4 90 86 1 −1 −5 4 294 3023 −2 1 4 379 377 4 6 6 4 40 35 1 −2 14 4 29 25 2 −5 −11 4 190 190 3 0 −54 267 251 3 −1 1 4 376 382 4 7 6 4 96 98 1 1 14 4 42 40 1 −4 −11 4 152165 3 1 −5 4 693 665 7 0 1 4 260 258 3 −7 7 4 14 13 1 2 14 4 67 67 1 −3−11 4 117 114 1 2 −5 4 276 267 3 1 1 4 124 115 1 −6 7 4 48 46 1 3 14 455 54 1 −2 −11 4 306 307 2 3 −5 4 255 257 4 2 1 4 200 198 2 −5 7 4 182184 1 4 14 4 67 62 1 −1 −11 4 141 140 1 4 −5 4 261 255 5 3 1 4 83 74 1−4 7 4 71 70 1 −4 15 4 103 103 2 0 −11 4 78 71 1 5 −5 4 77 84 1 4 1 4134 130 1 −3 7 4 52 47 1 −3 15 4 28 28 1 1 −11 4 70 73 1 6 −5 4 58 53 15 1 4 128 130 2 −2 7 4 231 230 6 1 15 4 47 45 1 2 −11 4 79 85 1 −8 −4 497 96 1 6 1 4 135 130 2 −1 7 4 73 77 2 2 15 4 75 76 1 3 −11 4 57 70 1 −7−4 4 37 33 1 7 1 4 54 55 1 0 7 4 192 186 3 3 15 4 30 30 1 4 −11 4 84 831 −6 −4 4 171 172 2 −8 2 4 10 10 2 1 7 4 30 21 3 −2 16 4 52 45 1 5 −11 490 89 1 −5 −4 4 154 162 2 −7 2 4 101 100 1 2 7 4 149 151 1 1 16 4 28 291 −6 −10 4 92 96 1 −4 −4 4 220 206 2 −6 2 4 130 130 2 3 7 4 121 122 1 −2−16 5 42 41 1 −5 −10 4 94 99 2 −3 −4 4 107 103 1 −5 2 4 121 129 1 4 7 4148 143 1 −1 −16 5 26 25 1 −4 −10 4 95 106 2 −2 −4 4 188 191 2 −4 2 4231 232 2 5 7 4 170 163 1 0 −16 5 24 27 1 −3 −10 4 58 53 1 −1 −4 4 125128 1 −3 2 4 256 245 3 6 7 4 18 13 1 1 −16 5 102 104 2 −2 −10 4 34 28 10 −4 4 384 375 4 −2 2 4 80 78 1 7 7 4 25 32 1 −3 −15 5 26 26 1 −1 −10 4140 146 1 1 −4 4 199 183 2 −1 2 4 203 205 2 −7 8 4 28 29 1 −2 −15 5 194186 2 0 −10 4 234 232 1 2 −4 4 198 192 2 0 2 4 563 566 7 −6 8 4 127 1311 −1 −15 5 59 58 1 1 −10 4 106 103 1 6 −4 4 90 87 1 1 2 4 107 115 1 −5 84 150 152 2 0 −15 5 82 82 1 2 −10 4 97 94 1 −8 −3 4 33 27 1 2 2 4 170169 2 −4 8 4 103 99 1 1 −15 5 99 91 1 3 −10 4 116 123 2 −7 −3 4 60 58 13 2 4 144 147 1 −3 8 4 91 89 1 2 −15 5 70 70 1 4 −10 4 123 121 2 −6 −3 4210 215 3 4 2 4 64 66 1 −2 8 4 62 67 1 −4 −14 5 114 112 1 5 −10 4 29 321 −5 −3 4 80 76 1 5 2 4 38 33 1 −1 8 4 68 70 2 −3 −14 5 127 130 1 6 −104 30 31 1 −4 −3 4 107 102 1 6 2 4 195 195 3 0 8 4 155 161 3 −2 −14 5 188191 1 −7 −9 4 51 48 1 −3 −3 4 145 142 1 7 2 4 30 23 1 1 8 4 130 142 2 −1−14 5 122 120 1 −6 −9 4 80 77 1 −2 −3 4 209 214 2 −8 3 4 34 27 1 2 8 4115 113 1 0 −14 5 57 59 1 −5 −9 4 94 96 1 −1 −3 4 189 191 2 −7 3 4 56 571 3 8 4 124 118 1 1 −14 5 10 9 1 −4 −9 4 18 19 1 0 −3 4 304 309 2 −6 3 4215 214 3 4 8 4 212 216 2 2 −14 5 68 67 1 −3 −9 4 137 136 1 1 −3 4 176180 1 −5 3 4 80 77 1 5 8 4 104 114 1 3 −14 5 59 61 1 −2 −9 4 154 156 1 2−3 4 281 289 3 −4 3 4 106 102 1 6 8 4 137 138 2 −5 −13 5 23 23 1 −1 −9 4156 159 1 3 −3 4 107 99 1 −3 3 4 143 142 2 −6 9 4 77 78 1 −4 −13 5 115116 1 0 −9 4 179 182 1 6 −3 4 61 58 1 −2 3 4 208 214 2 −5 9 4 95 97 1 −3−13 5 102 99 1 1 −9 4 218 214 1 7 −3 4 68 65 1 −1 3 4 184 191 2 −4 9 418 19 1 −2 −13 5 126 125 1 2 −9 4 68 65 1 −8 −2 4 13 10 1 0 3 4 308 3113 −3 9 4 137 136 1 −1 −13 5 99 107 1 3 −9 4 41 45 1 −7 −2 4 99 99 1 1 34 174 180 2 −2 9 4 153 157 2 0 −13 5 114 118 1 4 −9 4 78 78 1 −6 −2 4126 130 2 2 3 4 285 289 4 −1 9 4 152 158 2 1 −13 5 65 69 1 5 −9 4 125122 2 −5 −2 4 120 129 1 3 3 4 108 99 1 0 9 4 173 183 3 2 −13 5 37 38 1 6−9 4 89 92 1 −4 −2 4 231 231 3 4 3 4 73 77 1 1 9 4 218 213 3 3 −13 5 4855 1 −7 −8 4 29 29 1 −3 −2 4 256 245 2 5 3 4 105 109 1 2 9 4 68 64 1 4−13 5 32 37 1 −6 −8 4 129 131 2 −2 −2 4 79 78 1 6 3 4 59 58 1 3 9 4 4245 1 −6 −12 5 52 47 1 −5 −8 4 151 152 2 −1 −2 4 202 204 1 7 3 4 71 65 14 9 4 78 77 1 −5 −12 5 91 94 1 −4 −8 4 103 99 2 0 −2 4 559 566 5 −8 4 498 96 1 5 9 4 124 122 1 −4 −12 5 47 48 1 −3 −8 4 94 89 1 1 −2 4 109 1141 −7 4 4 36 33 1 −6 10 4 93 96 1 −3 −12 5 69 70 1 −2 −8 4 64 67 1 2 −2 4167 169 1 −6 4 4 172 172 2 −5 10 4 100 100 1 −2 −12 5 75 72 1 −1 −8 4 6870 1 3 −2 4 144 147 2 −5 4 4 154 162 1 −4 10 4 101 106 1 −1 −12 5 226230 1 0 −8 4 153 160 1 5 −2 4 39 33 1 −4 4 4 215 206 1 −3 10 4 57 53 1 0−12 5 155 146 1 1 −8 4 130 141 1 6 −2 4 197 195 3 −3 4 4 105 104 2 −2 104 36 28 1 1 −12 5 64 61 1 2 −8 4 115 113 1 7 −2 4 30 23 1 −2 4 4 186 1913 −1 10 4 138 146 2 2 −12 5 163 164 1 3 −8 4 127 119 2 −8 −1 4 40 38 1−1 4 4 129 127 2 0 10 4 235 232 3 3 −12 5 25 29 1 4 −8 4 211 216 3 −7 −14 141 143 2 0 4 4 390 374 6 1 10 4 106 104 2 4 −12 5 46 43 1 5 −8 4 105113 2 −6 −1 4 54 54 1 1 4 4 196 181 3 2 10 4 96 93 1 −6 −11 5 30 29 1 6−8 4 140 139 2 −5 −1 4 151 147 2 2 4 4 198 191 3 3 10 4 119 123 1 −5 −115 52 57 1 −7 −7 4 13 13 1 −4 −1 4 440 419 5 3 4 4 70 71 1 4 10 4 123 1211 −4 −11 5 55 54 1 −6 −7 4 49 45 1 −3 −1 4 85 83 1 4 4 4 53 51 1 5 10 430 32 1 −3 −11 5 163 156 1 −5 −7 4 185 184 3 −2 −1 4 375 376 4 5 4 4 170167 1 −6 11 4 87 86 1 −2 −11 5 266 268 2 −4 −7 4 72 69 1 −1 −1 4 374 3824 6 4 4 84 87 1 −5 11 4 190 190 2 −1 −11 5 304 302 2 −3 −7 4 52 48 1 0−1 4 261 258 2 7 4 4 43 43 1 −4 11 4 160 164 2 0 −11 5 138 144 1 −2 −7 4231 230 2 1 −1 4 123 115 1 −8 5 4 30 33 1 −3 11 4 117 114 2 1 −11 5 196199 1 −1 −7 4 72 76 2 2 −1 4 201 199 2 −7 5 4 40 43 1 −2 11 4 304 307 42 −11 5 148 152 1 0 −7 4 189 186 3 3 −1 4 80 75 1 −6 5 4 63 61 1 −1 11 4140 141 3 3 −11 5 95 99 1 1 −7 4 29 22 1 4 −1 4 132 130 2 −5 5 4 214 2131 0 11 4 75 71 2 4 −11 5 60 62 1 2 −7 4 153 152 1 5 −1 4 125 130 2 −4 54 56 54 1 1 11 4 70 74 1 5 −11 5 93 94 1 3 −7 4 121 122 2 6 −1 4 133 1302 −3 5 4 135 141 4 2 11 4 78 84 1 −6 −10 5 35 32 1 4 −7 4 149 142 2 7 −14 53 55 1 −2 5 4 397 407 10 3 11 4 62 70 1 −5 −10 5 202 209 3 5 −7 4 169163 3 −8 0 4 28 28 1 −1 5 4 300 302 5 4 11 4 88 83 1 −4 −10 5 185 202 36 −7 4 20 12 1 −7 0 4 47 40 1 0 5 4 283 251 4 5 11 4 87 89 1 −3 −10 5120 123 1 −7 −6 4 53 55 1 −6 0 4 131 132 2 2 5 4 280 266 7 −6 12 4 62 581 −2 −10 5 177 171 1 −6 −6 4 187 187 3 −5 0 4 320 331 5 3 5 4 262 257 2−5 12 4 38 33 1 −1 −10 5 95 96 1 −5 −6 4 140 142 2 −4 0 4 35 22 1 4 5 4272 254 2 −4 12 4 67 70 1 0 −10 5 97 95 1 −4 −6 4 216 208 3 −3 0 4 10393 1 5 5 4 80 85 1 −3 12 4 115 117 1 1 −10 5 93 92 1 −3 −6 4 44 41 1 −20 4 91 99 1 6 5 4 57 52 1 −2 12 4 69 72 2 2 −10 5 75 77 1 −2 −6 4 110102 1 −1 0 4 622 630 8 7 5 4 47 44 1 1 12 4 121 120 2 3 −10 5 56 60 1 −1−6 4 105 102 1 0 0 4 870 877 11 −8 6 4 71 71 1 2 12 4 52 50 1 4 −10 5 1719 1 0 −6 4 223 219 3 1 0 4 48 52 1 −7 6 4 54 55 1 3 12 4 21 19 1 5 −105 61 58 1 1 −6 4 188 180 2 2 0 4 176 173 2 −6 6 4 188 187 3 4 12 4 24 231 −7 −9 5 18 21 1 2 −6 4 36 34 1 3 0 4 94 105 1 −5 6 4 136 142 1 5 12 455 51 1 −6 −9 5 92 93 1 3 −6 4 142 137 2 4 0 4 53 59 1 −4 6 4 210 208 1−5 13 4 45 43 1 −5 −9 5 75 75 1 4 −6 4 231 232 4 5 0 4 66 69 1 −3 6 4 4340 1 −4 13 4 96 95 1 −4 −9 5 141 146 1 5 −6 4 61 61 1 6 0 4 127 124 2 −26 4 111 103 3 −3 13 4 124 127 1 −3 −9 5 73 73 1 −2 −9 5 78 77 1 −3 −3 5177 167 2 4 2 5 108 102 1 −1 8 5 12 11 3 −1 −13 6 122 125 1 −1 −9 5 162149 1 −2 −3 5 183 175 2 5 2 5 88 85 1 0 8 5 64 69 1 0 −13 6 79 85 1 0 −95 120 111 1 −1 −3 5 123 109 1 6 2 5 113 112 2 1 8 5 276 281 4 1 −13 6127 129 1 1 −9 5 55 55 1 0 −3 5 104 104 1 7 2 5 38 37 1 2 8 5 188 178 22 −13 6 43 46 1 2 −9 5 154 149 1 1 −3 5 155 167 1 −8 3 5 39 38 1 3 8 5212 222 2 3 −13 6 70 75 1 3 −9 5 25 22 1 2 −3 5 69 67 1 −7 3 5 67 79 1 48 5 61 64 1 −5 −12 6 65 61 1 4 −9 5 129 131 2 3 −3 5 67 79 1 −6 3 5 124131 1 5 8 5 74 75 1 −4 −12 6 64 62 1 5 −9 5 51 51 1 4 −3 5 13 10 1 −5 35 177 184 1 6 8 5 51 50 1 −3 −12 6 146 146 1 6 −9 5 58 53 1 5 −3 5 88 861 −4 3 5 98 92 1 −6 9 5 92 92 1 −2 −12 6 100 95 1 −7 −8 5 94 91 1 6 −3 560 61 1 −3 3 5 176 166 2 −5 9 5 79 76 1 −1 −12 6 145 160 1 −6 −8 5 47 441 7 −3 5 50 49 1 −2 3 5 178 175 2 −4 9 5 143 146 1 0 −12 6 133 135 1 −5−8 5 113 112 2 −8 −2 5 83 79 1 −1 3 5 124 110 2 −3 9 5 72 73 1 1 −12 6102 98 1 −4 −8 5 53 58 1 −7 −2 5 114 119 2 0 3 5 105 104 2 −2 9 5 80 771 2 −12 6 56 56 1 −3 −8 5 156 174 1 −6 −2 5 178 177 3 1 3 5 157 168 2 −19 5 160 149 2 3 −12 6 54 50 1 −2 −8 5 86 97 1 −5 −2 5 130 131 2 2 3 5 7067 1 0 9 5 118 111 2 4 −12 6 54 57 1 −1 −8 5 10 11 1 −4 −2 5 180 176 1 33 5 67 78 1 1 9 5 57 56 1 −6 −11 6 5 7 5 0 −8 5 64 69 1 −3 −2 5 165 1551 4 3 5 12 9 1 2 9 5 151 148 2 −5 −11 6 60 58 1 1 −8 5 277 281 2 −2 −2 5185 181 2 5 3 5 87 87 1 3 9 5 25 22 1 −4 −11 6 62 66 1 2 −8 5 188 177 1−1 −2 5 246 242 2 6 3 5 59 61 1 4 9 5 129 131 1 −3 −11 6 18 15 1 3 −8 5217 222 3 0 −2 5 325 312 4 7 3 5 50 48 1 5 9 5 50 51 1 −2 −11 6 71 74 14 −8 5 61 64 1 1 −2 5 219 204 2 −8 4 5 52 46 1 −6 10 5 34 32 1 −1 −11 6204 211 1 5 −8 5 77 76 1 2 −2 5 227 229 2 −7 4 5 62 59 1 −5 10 5 210 2092 0 −11 6 40 39 1 6 −8 5 51 49 1 3 −2 5 77 83 1 −6 4 5 95 93 1 −4 10 5195 203 2 1 −11 6 140 138 1 −7 −7 5 57 56 1 4 −2 5 109 103 1 −5 4 5 234237 1 −3 10 5 120 124 1 2 −11 6 106 117 1 −6 −7 5 107 109 1 5 −2 5 86 841 −4 4 5 143 147 1 −2 10 5 178 171 2 3 −11 6 104 108 2 −5 −7 5 43 44 1 6−2 5 114 112 1 −3 4 5 229 227 6 −1 10 5 92 96 2 4 −11 6 90 87 1 −4 −7 5163 165 1 7 −2 5 38 36 1 −2 4 5 70 73 1 0 10 5 96 95 1 5 −11 6 113 110 2−3 −7 5 116 114 1 −8 −1 5 133 120 2 −1 4 5 218 210 3 1 10 5 95 92 1 −6−10 6 27 23 1 −2 −7 5 66 72 1 −7 −1 5 18 19 1 0 4 5 275 252 4 2 10 5 7578 1 −5 −10 6 162 171 2 −1 −7 5 97 88 1 −6 −1 5 169 166 3 1 4 5 496 5019 3 10 5 56 60 1 −4 −10 6 225 234 2 0 −7 5 122 122 1 −5 −1 5 117 119 1 24 5 118 122 2 4 10 5 19 19 1 −3 −10 6 124 124 1 1 −7 5 273 279 1 −4 −1 5315 317 3 3 4 5 55 58 1 5 10 5 60 57 1 −2 −10 6 162 163 1 2 −7 5 199 2051 −3 −1 5 39 46 1 4 4 5 137 141 1 −6 11 5 30 29 1 −1 −10 6 164 161 1 3−7 5 48 45 1 −2 −1 5 128 131 1 5 4 5 52 46 1 −5 11 5 52 56 1 0 −10 6 4843 1 4 −7 5 54 51 1 −1 −1 5 211 223 2 6 4 5 74 76 1 −4 11 5 54 54 1 1−10 6 96 97 1 5 −7 5 64 61 1 0 −1 5 83 72 1 7 4 5 60 58 1 −3 11 5 161156 2 2 −10 6 32 33 1 6 −7 5 20 21 1 1 −1 5 190 188 2 −8 5 5 96 95 1 −211 5 272 268 5 3 −10 6 48 46 1 −7 −6 5 75 72 1 2 −1 5 253 249 3 −7 5 556 63 1 −1 11 5 300 302 6 4 −10 6 46 46 1 −6 −6 5 143 142 1 3 −1 5 90 901 −6 5 5 154 158 2 0 11 5 135 144 2 5 −10 6 77 82 1 −5 −6 5 202 199 3 4−1 5 92 97 1 −5 5 5 227 233 1 1 11 5 196 199 3 −7 −9 6 53 56 1 −4 −6 523 21 1 5 −1 5 151 149 2 −4 5 5 190 191 1 2 11 5 149 153 2 −6 −9 6 67 651 −3 −6 5 126 127 1 6 −1 5 92 92 1 −3 5 5 232 248 3 3 11 5 90 99 1 −5 −96 57 65 1 −2 −6 5 132 130 1 7 −1 5 133 131 2 −2 5 5 114 121 3 4 11 5 6362 1 −4 −9 6 136 141 1 −1 −6 5 294 309 5 −8 0 5 18 20 1 −1 5 5 332 325 55 11 5 90 94 1 −3 −9 6 117 116 1 0 −6 5 208 204 2 −7 0 5 61 71 1 0 5 573 67 1 −5 12 5 88 93 1 −2 −9 6 128 124 1 1 −6 5 360 355 4 −6 0 5 46 421 1 5 5 128 128 3 −4 12 5 48 48 1 −1 −9 6 137 136 1 2 −6 5 37 25 1 −5 05 36 37 1 2 5 5 364 356 5 −3 12 5 68 70 1 0 −9 6 224 219 1 3 −6 5 55 501 −4 0 5 500 502 5 3 5 5 77 61 1 −2 12 5 77 71 2 1 −9 6 170 174 1 4 −6 532 26 1 −3 0 5 196 207 2 4 5 5 193 198 1 0 12 5 151 147 3 2 −9 6 122 1141 5 −6 5 137 134 2 −2 0 5 224 231 2 5 5 5 292 291 2 1 12 5 67 62 1 3 −96 159 171 3 6 −6 5 30 26 1 −1 0 5 170 178 2 6 5 5 142 139 2 2 12 5 161164 2 4 −9 6 51 43 1 −8 −5 5 98 96 1 0 0 5 40 40 1 7 5 5 24 22 1 3 12 528 29 1 5 −9 6 69 69 1 −7 −5 5 56 63 1 1 0 5 57 50 1 −8 6 5 80 82 1 4 125 46 43 1 −7 −8 6 33 35 1 −6 −5 5 155 158 1 2 0 5 129 127 1 −7 6 5 74 731 −5 13 5 27 23 1 −6 −8 6 190 191 2 −5 −5 5 230 233 4 3 0 5 68 65 1 −6 65 144 143 1 −4 13 5 116 116 1 −5 −8 6 79 79 1 −4 −5 5 190 191 1 4 0 5 3736 1 −5 6 5 201 199 2 −3 13 5 102 98 1 −4 −8 6 16 14 1 −3 −5 5 233 247 15 0 5 43 36 1 −4 6 5 25 22 1 −2 13 5 126 125 2 −3 −8 6 94 104 1 −2 −5 5113 120 1 6 0 5 198 196 3 −3 6 5 124 127 1 1 13 5 64 69 1 −2 −8 6 24 301 −1 −5 5 314 324 4 7 0 5 74 71 1 −2 6 5 125 129 4 2 13 5 37 38 1 −1 −86 118 117 1 0 −5 5 70 66 1 −8 1 5 134 120 2 −1 6 5 303 309 5 3 13 5 5155 1 0 −8 6 250 248 1 1 −5 5 133 128 1 −7 1 5 18 18 1 0 6 5 210 204 3 413 5 35 37 1 1 −8 6 65 66 1 2 −5 5 363 357 3 −6 1 5 170 167 3 1 6 5 360354 9 −4 14 5 117 111 2 2 −8 6 240 233 2 3 −5 5 76 61 1 −5 1 5 115 119 12 6 5 37 25 1 −3 14 5 129 130 1 3 −8 6 69 60 1 4 −5 5 193 197 3 −4 1 5309 317 2 3 6 5 54 50 1 −2 14 5 186 191 3 4 −8 6 171 169 3 5 −5 5 292291 5 −3 1 5 38 46 1 4 6 5 32 27 1 1 14 5 10 9 4 5 −8 6 119 118 2 6 −5 5140 139 2 −2 1 5 128 132 1 5 6 5 136 134 1 2 14 5 68 67 1 6 −8 6 54 53 1−8 −4 5 53 46 1 −1 1 5 212 224 2 6 6 5 28 25 1 3 14 5 61 61 1 −7 −7 6 6360 1 −7 −4 5 63 60 1 0 1 5 81 71 1 7 6 5 38 41 1 −3 15 5 28 26 1 −6 −7 6104 103 1 −6 −4 5 94 93 1 1 1 5 192 188 2 −7 7 5 57 57 1 1 15 5 96 91 1−5 −7 6 7 10 2 −5 −4 5 235 235 2 2 1 5 254 249 3 −6 7 5 104 110 1 2 15 569 70 1 −4 −7 6 70 70 1 −4 −4 5 145 147 1 3 1 5 90 90 1 −5 7 5 43 44 1−3 −15 6 95 90 1 −3 −7 6 54 55 1 −3 −4 5 231 227 2 4 1 5 92 98 1 −4 7 5163 165 1 −2 −15 6 89 86 1 −2 −7 6 93 90 1 −2 −4 5 70 73 1 5 1 5 152 1492 −3 7 5 114 114 1 −1 −15 6 165 163 1 −1 −7 6 18 17 1 −1 −4 5 212 210 26 1 5 93 92 1 −2 7 5 70 72 1 0 −15 6 73 74 1 0 −7 6 219 210 1 0 −4 5 275253 3 7 1 5 132 131 1 −1 7 5 100 89 2 1 −15 6 95 89 1 1 −7 6 121 121 1 1−4 5 513 499 6 −8 2 5 82 79 1 0 7 5 123 122 2 2 −15 6 61 62 1 2 −7 6 92100 1 2 −4 5 120 122 1 −7 2 5 109 119 2 1 7 5 280 280 4 −4 −14 6 92 95 13 −7 6 108 103 2 3 −4 5 54 57 1 −6 2 5 176 177 3 2 7 5 200 206 2 −3 −146 153 149 1 4 −7 6 233 238 4 4 −4 5 139 142 2 −5 2 5 131 131 1 3 7 5 4645 1 −2 −14 6 140 136 1 5 −7 6 87 81 1 5 −4 5 52 46 1 −4 2 5 177 175 1 47 5 55 52 1 −1 −14 6 49 51 1 6 −7 6 60 60 1 6 −4 5 77 76 1 −3 2 5 161156 2 5 7 5 62 61 1 0 −14 6 39 44 1 −7 −6 6 51 52 1 7 −4 5 62 59 1 −2 25 184 182 2 6 7 5 18 21 1 1 −14 6 38 38 1 −6 −6 6 63 60 1 −8 −3 5 37 371 −1 2 5 244 243 3 −6 8 5 45 44 1 2 −14 6 37 39 1 −5 −6 6 45 47 1 −7 −35 75 79 1 0 2 5 318 312 4 −5 8 5 111 112 1 −5 −13 6 53 54 1 −4 −6 6 105106 1 −6 −3 5 128 131 2 1 2 5 218 203 3 −4 8 5 54 58 1 −4 −13 6 87 87 1−3 −6 6 93 92 1 −5 −3 5 181 184 2 2 2 5 228 228 3 −3 8 5 159 175 1 −3−13 6 53 55 1 −2 −6 6 177 173 1 −4 −3 5 101 93 1 3 2 5 77 83 1 −2 8 5 8798 1 −2 −13 6 99 96 1 −1 −6 6 42 46 1 0 −6 6 101 105 1 −6 0 6 145 155 21 5 6 94 95 3 2 12 6 57 56 1 −5 −8 7 186 208 2 1 −6 6 217 220 1 −5 0 668 63 1 2 5 6 109 119 1 3 12 6 54 50 1 −4 −8 7 87 90 1 2 −6 6 124 128 1−4 0 6 79 66 1 3 5 6 143 142 1 4 12 6 55 56 1 −3 −8 7 60 69 1 3 −6 6 149142 1 −3 0 6 24 10 2 4 5 6 50 53 1 −5 13 6 54 55 1 −2 −8 7 224 237 1 4−6 6 48 46 1 −2 0 6 159 167 2 5 5 6 169 162 1 −4 13 6 89 87 1 −1 −8 7 6553 1 5 −6 6 70 65 1 −1 0 6 435 444 7 6 5 6 80 82 1 −3 13 6 51 55 1 0 −87 318 324 2 6 −6 6 76 76 1 0 0 6 265 270 3 −7 6 6 51 51 1 −2 13 6 98 962 1 −8 7 397 401 3 −8 −5 6 43 45 1 1 0 6 95 95 1 −6 6 6 62 60 1 0 13 679 85 2 2 −8 7 120 114 1 −7 −5 6 55 54 1 2 0 6 82 83 1 −5 6 6 48 47 1 113 6 127 130 2 3 −8 7 42 39 1 −6 −5 6 155 153 2 3 0 6 7 9 1 −4 6 6 105106 1 2 13 6 44 46 1 4 −8 7 18 18 1 −5 −5 6 36 39 1 4 0 6 4 7 4 −3 6 694 92 1 3 13 6 71 75 1 5 −8 7 43 43 1 −4 −5 6 24 23 1 5 0 6 54 54 1 −2 66 178 174 2 −4 14 6 94 95 1 −7 −7 7 34 34 1 −3 −5 6 113 111 1 6 0 6 5958 1 −1 6 6 43 46 2 −3 14 6 152 149 2 −6 −7 7 131 130 2 −2 −5 6 107 1121 7 0 6 43 40 1 0 6 6 103 105 2 −2 14 6 136 136 2 −5 −7 7 58 62 1 −1 −56 317 317 5 −8 1 6 45 41 1 1 6 6 219 219 3 1 14 6 38 37 1 −4 −7 7 69 621 0 −5 6 332 330 5 −7 1 6 48 43 1 2 6 6 122 128 1 2 14 6 39 40 1 −3 −7 756 55 1 1 −5 6 93 96 1 −6 1 6 161 167 2 3 6 6 148 141 1 3 14 6 99 95 2−2 −7 7 42 43 1 2 −5 6 109 119 1 −5 1 6 150 148 1 4 6 6 47 46 1 −3 15 693 90 1 −1 −7 7 67 71 1 3 −5 6 143 142 1 −4 1 6 114 113 1 5 6 6 71 65 11 15 6 90 89 1 0 −7 7 118 116 1 4 −5 6 52 53 1 −3 1 6 143 138 2 6 6 6 7576 1 2 15 6 60 61 1 1 −7 7 65 62 1 5 −5 6 171 162 3 −2 1 6 85 81 1 −7 76 57 60 1 −2 −15 7 99 99 1 2 −7 7 147 148 1 6 −5 6 80 83 1 −1 1 6 543538 9 −6 7 6 102 103 1 −1 −15 7 63 59 1 3 −7 7 71 72 1 −8 −4 6 37 33 1 01 6 247 262 3 −5 7 6 7 10 3 0 −15 7 108 110 1 4 −7 7 17 11 1 −7 −4 6 7478 1 1 1 6 89 82 1 −4 7 6 71 70 1 1 −15 7 77 76 1 5 −7 7 83 81 1 −6 −4 650 47 1 2 1 6 182 176 2 −3 7 6 55 54 1 −4 −14 7 62 61 1 6 −7 7 45 41 1−5 −4 6 46 46 1 3 1 6 48 47 1 −2 7 6 93 91 1 −3 −14 7 39 38 1 −7 −6 7 2323 1 −4 −4 6 106 107 1 4 1 6 78 85 1 −1 7 6 15 17 2 −2 −14 7 72 74 1 −6−6 7 16 14 1 −3 −4 6 62 67 1 5 1 6 85 83 1 0 7 6 220 211 3 −1 −14 7 3834 1 −5 −6 7 196 200 2 −2 −4 6 34 33 1 6 1 6 93 87 1 1 7 6 122 122 2 0−14 7 59 58 1 −4 −6 7 162 163 1 −1 −4 6 227 221 4 7 1 6 27 29 1 2 7 6 92100 1 1 −14 7 76 75 1 −3 −6 7 84 83 1 0 −4 6 295 279 4 −8 2 6 52 51 1 37 6 105 103 1 2 −14 7 97 96 1 −2 −6 7 114 112 1 1 −4 6 152 148 2 −7 2 632 35 1 4 7 6 228 239 2 −4 −13 7 55 53 1 −1 −6 7 44 38 1 2 −4 6 190 1941 −6 2 6 210 211 2 5 7 6 84 81 1 −3 −13 7 98 97 1 0 −6 7 57 51 1 3 −4 651 53 1 −5 2 6 43 37 1 6 7 6 55 60 1 −2 −13 7 93 90 1 1 −6 7 59 57 1 4−4 6 123 120 2 −4 2 6 146 153 1 −6 8 6 188 191 2 −1 −13 7 75 70 1 2 −6 7198 199 1 5 −4 6 53 52 1 −3 2 6 139 135 2 −5 8 6 85 80 1 0 −13 7 53 48 13 −6 7 122 121 1 6 −4 6 118 112 2 −2 2 6 47 46 1 −4 8 6 21 15 1 1 −13 765 65 1 4 −6 7 68 66 1 −8 −3 6 56 47 1 −1 2 6 383 369 6 −3 8 6 96 104 12 −13 7 111 113 1 5 −6 7 66 65 1 −7 −3 6 83 82 1 0 2 6 476 464 8 −2 8 625 30 1 3 −13 7 90 92 1 6 −6 7 71 67 1 −6 −3 6 38 34 1 1 2 6 403 396 5−1 8 6 117 116 1 −5 −12 7 23 22 1 −8 −5 7 56 52 1 −5 −3 6 105 106 1 2 26 145 145 2 0 8 6 252 248 3 −4 −12 7 132 132 1 −7 −5 7 7 9 6 −4 −3 6 111116 1 3 2 6 53 53 1 1 8 6 63 65 1 −3 −12 7 29 22 1 −6 −5 7 47 44 1 −3 −36 140 140 2 4 2 6 161 158 1 2 8 6 239 232 2 −2 −12 7 98 94 1 −5 −5 7 113115 1 −2 −3 6 36 35 1 5 2 6 146 151 2 3 8 6 68 60 1 −1 −12 7 87 89 1 −4−5 7 91 95 1 −1 −3 6 196 199 3 6 2 6 41 42 1 4 8 6 169 169 2 0 −12 7 6669 1 −3 −5 7 147 145 1 0 −3 6 353 336 4 7 2 6 64 68 1 5 8 6 118 118 2 1−12 7 114 116 1 −2 −5 7 165 174 1 1 −3 6 147 144 2 −8 3 6 54 47 1 −6 9 668 65 1 2 −12 7 94 93 1 −1 −5 7 106 104 1 2 −3 6 99 102 1 −7 3 6 82 81 1−5 9 6 60 65 1 3 −12 7 10 7 2 0 −5 7 211 208 2 3 −3 6 45 49 1 −6 3 6 3634 1 −4 9 6 133 140 1 4 −12 7 53 54 1 1 −5 7 107 109 1 4 −3 6 24 25 1 −53 6 104 105 1 −3 9 6 119 116 1 −6 −11 7 18 16 1 2 −5 7 125 128 1 5 −3 6138 143 2 −4 3 6 109 116 1 −2 9 6 127 123 2 −5 −11 7 118 117 1 3 −5 7105 108 1 6 −3 6 141 135 2 −3 3 6 140 140 4 −1 9 6 134 136 2 −4 −11 7115 114 1 4 −5 7 66 69 1 7 −3 6 19 14 1 −2 3 6 36 35 2 0 9 6 223 219 3−3 −11 7 129 135 1 5 −5 7 83 83 1 −8 −2 6 55 51 1 −1 3 6 208 199 3 1 9 6167 174 2 −2 −11 7 40 39 1 6 −5 7 15 17 1 −7 −2 6 32 35 1 0 3 6 357 3356 2 9 6 123 115 1 −1 −11 7 46 46 1 −8 −4 7 18 14 1 −6 −2 6 212 211 3 1 36 144 145 4 3 9 6 173 171 2 0 −11 7 51 54 1 −7 −4 7 50 55 1 −5 −2 6 4438 1 2 3 6 98 101 1 4 9 6 51 44 1 1 −11 7 136 144 1 −6 −4 7 149 151 2 −4−2 6 147 153 1 3 3 6 46 49 1 5 9 6 70 70 1 2 −11 7 76 84 1 −5 −4 7 39 411 −3 −2 6 143 134 2 4 3 6 24 25 1 −6 10 6 25 23 1 3 −11 7 137 135 2 −4−4 7 199 205 1 −2 −2 6 46 46 1 5 3 6 139 144 2 −5 10 6 165 172 2 4 −11 781 80 1 −3 −4 7 111 112 1 −1 −2 6 380 368 6 6 3 6 139 135 2 −4 10 6 231233 3 −6 −10 7 112 115 2 −2 −4 7 158 160 3 0 −2 6 481 464 6 7 3 6 18 141 −3 10 6 125 124 1 −5 −10 7 82 80 1 −1 −4 7 392 399 6 1 −2 6 412 397 5−8 4 6 37 33 1 −2 10 6 166 163 2 −4 −10 7 212 211 1 0 −4 7 174 173 3 2−2 6 144 146 1 −7 4 6 70 78 1 −1 10 6 164 162 3 −3 −10 7 165 168 1 1 −47 361 375 2 3 −2 6 54 53 1 −6 4 6 50 47 1 0 10 6 46 43 1 −2 −10 7 91 851 2 −4 7 67 59 1 4 −2 6 163 157 2 −5 4 6 43 45 1 1 10 6 99 97 2 −1 −10 7241 238 1 3 −4 7 37 37 1 5 −2 6 153 151 1 −4 4 6 104 107 1 2 10 6 35 341 0 −10 7 95 89 1 4 −4 7 101 93 1 6 −2 6 39 41 1 −3 4 6 60 66 1 3 10 646 46 1 1 −10 7 54 53 1 5 −4 7 176 173 3 7 −2 6 64 68 1 −2 4 6 33 33 2 410 6 47 45 1 2 −10 7 63 56 1 6 −4 7 100 99 1 −8 −1 6 45 41 1 −1 4 6 237222 4 5 10 6 78 82 1 3 −10 7 39 37 1 −8 −3 7 25 21 1 −7 −1 6 51 44 1 0 46 300 278 5 −6 11 6 0 7 1 4 −10 7 43 38 1 −7 −3 7 49 56 1 −6 −1 6 167166 2 1 4 6 154 148 4 −5 11 6 62 58 1 5 −10 7 76 72 1 −6 −3 7 45 39 1 −5−1 6 150 149 1 2 4 6 191 195 1 −4 11 6 58 65 1 −7 −9 7 83 84 1 −5 −3 7171 170 1 −4 −1 6 114 113 1 3 4 6 50 52 1 −3 11 6 20 15 1 −6 −9 7 47 501 −4 −3 7 145 143 1 −3 −1 6 145 138 2 4 4 6 122 120 1 −2 11 6 74 74 2 −5−9 7 114 116 1 −3 −3 7 31 27 1 −2 −1 6 84 80 1 5 4 6 54 53 1 0 11 6 4038 1 −4 −9 7 57 57 1 −2 −3 7 144 138 2 −1 −1 6 534 537 10 6 4 6 118 1132 1 11 6 140 139 2 −3 −9 7 136 141 1 −1 −3 7 226 219 4 0 −1 6 249 262 37 4 6 46 42 1 2 11 6 106 117 1 −2 −9 7 135 140 1 0 −3 7 115 108 2 1 −1 689 81 1 −8 5 6 42 45 1 3 11 6 103 109 1 −1 −9 7 113 109 1 1 −3 7 299 2964 2 −1 6 177 176 2 −7 5 6 56 55 1 4 11 6 91 87 1 0 −9 7 93 97 1 2 −3 719 10 1 3 −1 6 48 48 1 −6 5 6 151 154 1 5 11 6 113 110 2 1 −9 7 254 2572 3 −3 7 106 109 1 4 −1 6 78 85 1 −5 5 6 39 39 1 −5 12 6 65 61 1 2 −9 7179 174 1 4 −3 7 169 166 3 5 −1 6 89 84 1 −4 5 6 25 23 1 −4 12 6 66 62 13 −9 7 19 18 1 5 −3 7 81 84 1 6 −1 6 95 87 1 −3 5 6 115 111 2 −3 12 6149 145 2 4 −9 7 44 41 1 6 −3 7 146 142 2 7 −1 6 27 29 1 −2 5 6 111 1113 −2 12 6 100 95 2 5 −9 7 65 60 1 −8 −2 7 37 33 1 −8 0 6 45 50 1 −1 5 6319 319 5 0 12 6 134 135 2 −7 −8 7 29 29 1 −7 −2 7 70 67 1 −7 0 6 34 281 0 5 6 329 329 5 1 12 6 101 97 2 −6 −8 7 39 45 1 −6 −2 7 162 161 2 −5−2 7 213 210 1 −8 4 7 13 14 1 2 10 7 62 56 1 1 −9 8 183 188 1 6 −3 8 6161 1 −4 −2 7 161 155 1 −7 4 7 49 54 1 3 10 7 42 38 1 2 −9 8 81 87 1 −8−2 8 19 17 1 −3 −2 7 108 111 1 −6 4 7 149 152 1 4 10 7 42 37 1 3 −9 8 4041 1 −7 −2 8 58 53 1 −2 −2 7 331 340 5 −5 4 7 39 41 1 5 10 7 75 72 1 4−9 8 58 59 1 −6 −2 8 137 141 2 −1 −2 7 170 169 3 −4 4 7 202 206 1 −6 117 18 17 1 5 −9 8 58 63 1 −5 −2 8 242 244 2 0 −2 7 439 422 7 −3 4 7 108112 1 −5 11 7 121 117 1 −7 −8 8 71 69 1 −4 −2 8 181 178 1 1 −2 7 210 2032 −2 4 7 158 160 3 −4 11 7 115 114 1 −6 −8 8 18 17 1 −3 −2 8 198 204 1 2−2 7 94 89 1 −1 4 7 386 399 6 −3 11 7 131 135 1 −5 −8 8 38 38 1 −2 −2 8410 403 5 3 −2 7 60 58 1 0 4 7 174 173 3 −2 11 7 35 39 2 −4 −8 8 19 20 1−1 −2 8 201 205 3 4 −2 7 189 191 3 1 4 7 365 375 5 0 11 7 51 54 1 −3 −88 11 13 1 0 −2 8 283 288 3 5 −2 7 219 220 3 2 4 7 70 59 1 1 11 7 140 1432 −2 −8 8 188 191 1 1 −2 8 102 108 1 6 −2 7 152 151 2 3 4 7 38 37 1 2 117 77 84 1 −1 −8 8 168 171 1 2 −2 8 22 24 1 −8 −1 7 70 70 1 4 4 7 99 94 13 11 7 138 135 1 0 −8 8 160 163 1 3 −2 8 110 109 1 −7 −1 7 106 107 1 5 47 175 173 2 4 11 7 83 81 1 1 −8 8 310 308 2 4 −2 8 31 33 1 −6 −1 7 151151 2 6 4 7 100 99 1 −5 12 7 24 22 1 2 −8 8 184 186 2 5 −2 8 133 139 2−5 −1 7 38 34 1 −8 5 7 53 52 1 −4 12 7 136 132 1 3 −8 8 125 135 2 6 −2 8153 148 2 −4 −1 7 189 195 1 −7 5 7 0 8 1 −3 12 7 26 22 1 4 −8 8 130 1332 −8 −1 8 39 39 1 −3 −1 7 143 137 2 −6 5 7 49 44 1 −2 12 7 97 93 2 5 −88 32 31 1 −7 −1 8 84 83 1 −2 −1 7 133 124 2 −5 5 7 114 115 1 0 12 7 6469 1 −7 −7 8 35 31 1 −6 −1 8 39 40 1 −1 −1 7 128 120 2 −4 5 7 90 95 1 112 7 114 115 1 −6 −7 8 147 143 2 −5 −1 8 78 78 1 0 −1 7 44 45 1 −3 5 7148 145 1 2 12 7 96 92 1 −5 −7 8 21 19 1 −4 −1 8 121 131 1 1 −1 7 27 321 −2 5 7 165 174 2 3 12 7 4 7 3 −4 −7 8 69 66 1 −3 −1 8 24 21 1 2 −1 779 77 1 −1 5 7 109 104 2 4 12 7 55 54 1 −3 −7 8 27 33 1 −2 −1 8 129 1372 3 −1 7 64 63 1 0 5 7 216 208 4 −4 13 7 57 53 1 −2 −7 8 68 65 1 −1 −1 887 87 2 4 −1 7 36 34 1 1 5 7 109 110 1 −3 13 7 96 96 1 −1 −7 8 45 49 1 0−1 8 69 72 2 5 −1 7 51 47 1 2 5 7 126 128 1 −2 13 7 90 90 2 0 −7 8 124127 1 1 −1 8 265 270 2 6 −1 7 153 147 2 3 5 7 105 109 1 0 13 7 49 49 1 1−7 8 148 146 1 2 −1 8 106 113 1 −8 0 7 169 156 2 4 5 7 65 69 1 1 13 7 6465 1 2 −7 8 78 74 1 3 −1 8 101 102 1 −7 0 7 116 119 2 5 5 7 82 83 1 2 137 116 114 1 3 −7 8 77 82 1 4 −1 8 36 37 1 −6 0 7 28 33 1 6 5 7 17 17 1 313 7 92 92 1 4 −7 8 63 71 1 5 −1 8 22 20 1 −5 0 7 52 56 1 −7 6 7 23 23 1−4 14 7 62 61 1 5 −7 8 101 98 2 6 −1 8 49 47 1 −4 0 7 48 46 1 −6 6 7 1614 1 −3 14 7 36 38 1 −7 −6 8 63 65 1 −8 0 8 21 11 1 −3 0 7 39 38 1 −5 67 200 200 2 −2 14 7 69 74 1 −6 −6 8 154 167 2 −7 0 8 102 93 1 −2 0 7 9091 2 −4 6 7 162 163 1 1 14 7 75 75 1 −5 −6 8 60 62 1 −6 0 8 216 236 2 −10 7 84 99 2 −3 6 7 85 84 1 2 14 7 97 96 1 −4 −6 8 113 112 1 −5 0 8 225234 1 0 0 7 67 71 1 −2 6 7 115 112 2 1 15 7 74 75 1 −3 −6 8 151 150 1 −40 8 87 85 1 1 0 7 229 238 3 −1 6 7 42 38 1 −1 −15 8 26 32 1 −2 −6 8 4343 1 −3 0 8 14 11 1 2 0 7 281 295 2 0 6 7 58 51 1 −3 −14 8 53 56 1 −1 −68 88 85 1 −2 0 8 18 19 3 3 0 7 16 20 1 1 6 7 58 57 1 −2 −14 8 49 49 1 0−6 8 95 100 1 −1 0 8 215 205 4 4 0 7 38 35 1 2 6 7 198 198 2 −1 −14 8 4649 1 1 −6 8 75 73 1 0 0 8 49 26 2 5 0 7 53 54 1 3 6 7 120 120 1 0 −14 847 47 1 2 −6 8 256 253 2 1 0 8 31 31 1 6 0 7 187 191 3 4 6 7 68 66 1 1−14 8 83 77 1 3 −6 8 100 98 2 2 0 8 19 19 1 −8 1 7 72 70 1 5 6 7 65 65 1−4 −13 8 44 44 1 4 −6 8 105 108 2 3 0 8 202 204 1 −7 1 7 103 107 2 6 6 770 67 1 −3 −13 8 38 36 1 5 −6 8 9 10 2 4 0 8 47 48 1 −6 1 7 149 151 1 −67 7 128 130 1 −2 −13 8 124 120 1 −7 −5 8 14 16 1 5 0 8 39 36 1 −5 1 7 3533 1 −5 7 7 62 61 1 −1 −13 8 23 23 1 −6 −5 8 32 34 1 6 0 8 27 28 1 −4 17 185 194 1 −4 7 7 69 62 1 0 −13 8 37 36 1 −5 −5 8 61 62 1 −8 1 8 39 371 −3 1 7 140 136 2 −3 7 7 58 56 1 1 −13 8 30 31 1 −4 −5 8 120 122 1 −7 18 85 83 1 −2 1 7 134 125 2 −2 7 7 43 42 1 2 −13 8 9 8 2 −3 −5 8 91 95 1−6 1 8 39 40 1 −1 1 7 129 120 2 −1 7 7 68 71 1 −5 −12 8 32 29 1 −2 −5 8103 108 1 −5 1 8 77 78 1 0 1 7 44 45 2 0 7 7 118 116 2 −4 −12 8 39 41 1−1 −5 8 142 140 1 −4 1 8 122 130 1 1 1 7 27 32 1 1 7 7 66 62 1 −3 −12 898 94 1 0 −5 8 107 109 1 −3 1 8 23 21 1 2 1 7 79 78 1 2 7 7 148 149 1 −2−12 8 63 57 1 1 −5 8 107 114 1 −2 1 8 133 137 2 3 1 7 64 64 1 3 7 7 7372 1 −1 −12 8 77 81 1 2 −5 8 134 136 1 −1 1 8 86 88 2 4 1 7 35 34 1 4 77 15 10 1 0 −12 8 18 19 1 3 −5 8 66 70 1 0 1 8 70 73 2 5 1 7 50 47 1 5 77 81 82 1 1 −12 8 98 91 1 4 −5 8 33 35 1 1 1 8 267 271 3 6 1 7 149 147 2−6 8 7 40 44 1 2 −12 8 44 47 1 5 −5 8 22 19 1 2 1 8 106 112 1 −8 2 7 3834 1 −5 8 7 205 208 2 3 −12 8 71 74 1 6 −5 8 67 64 1 3 1 8 100 102 1 −72 7 67 67 1 −4 8 7 87 90 1 −6 −11 8 26 29 1 −8 −4 8 40 39 1 4 1 8 36 371 −6 2 7 161 161 1 −3 8 7 61 69 1 −5 −11 8 101 103 1 −7 −4 8 81 80 1 5 18 23 20 1 −5 2 7 212 210 1 −2 8 7 223 237 3 −4 −11 8 33 32 1 −6 −4 8 4341 1 6 1 8 48 47 1 −4 2 7 160 155 1 −1 8 7 64 53 1 −3 −11 8 92 90 1 −5−4 8 37 30 1 −8 2 8 16 16 1 −3 2 7 106 111 1 0 8 7 318 324 4 −2 −11 8173 175 1 −4 −4 8 58 55 1 −7 2 8 58 53 1 −2 2 7 330 340 5 1 8 7 399 4016 −1 −11 8 89 103 1 −3 −4 8 127 133 1 −6 2 8 146 142 1 −1 2 7 173 169 32 8 7 120 115 1 0 −11 8 133 132 1 −2 −4 8 17 20 1 −5 2 8 240 244 2 0 2 7447 421 7 3 8 7 43 39 1 1 −11 8 55 60 1 −1 −4 8 70 80 1 −4 2 8 181 178 11 2 7 210 203 5 4 8 7 19 18 1 2 −11 8 79 79 1 0 −4 8 200 201 1 −3 2 8198 204 1 2 2 7 93 89 1 5 8 7 42 43 1 3 −11 8 0 7 1 1 −4 8 64 62 1 −2 28 400 403 5 3 2 7 59 58 1 −6 9 7 47 50 1 4 −11 8 22 26 1 2 −4 8 150 1471 −1 2 8 203 204 3 4 2 7 187 191 1 −5 9 7 118 117 1 −6 −10 8 44 45 1 3−4 8 83 80 1 0 2 8 280 288 5 5 2 7 199 220 2 −4 9 7 57 58 1 −5 −10 8 7073 1 4 −4 8 104 104 2 1 2 8 102 107 1 6 2 7 151 151 1 −3 9 7 137 141 1−4 −10 8 66 69 1 5 −4 8 150 147 2 2 2 8 22 25 1 −8 3 7 26 21 1 −2 9 7133 140 2 −3 −10 8 101 100 1 6 −4 8 116 109 2 3 2 8 109 109 1 −7 3 7 4956 1 −1 9 7 111 110 2 −2 −10 8 53 58 1 −8 −3 8 29 28 1 4 2 8 33 32 1 −63 7 47 39 1 0 9 7 88 97 1 −1 −10 8 175 167 1 −7 −3 8 50 51 1 5 2 8 134138 2 −5 3 7 172 171 1 1 9 7 253 257 3 0 −10 8 126 131 1 −6 −3 8 140 1502 6 2 8 149 148 2 −4 3 7 145 143 1 2 9 7 179 174 2 1 −10 8 71 69 1 −5 −38 161 165 1 −8 3 8 29 28 1 −3 3 7 30 27 1 3 9 7 21 18 1 2 −10 8 46 50 1−4 −3 8 145 157 1 −7 3 8 49 51 1 −2 3 7 145 138 2 4 9 7 44 42 1 3 −10 8116 116 2 −3 −3 8 127 130 1 −6 3 8 152 149 1 −1 3 7 224 219 4 5 9 7 6461 1 4 −10 8 28 30 1 −2 −3 8 116 115 1 −5 3 8 160 166 1 0 3 7 115 108 2−6 10 7 113 115 1 −6 −9 8 35 35 1 −1 −3 8 323 314 4 −4 3 8 148 157 1 1 37 304 297 7 −5 10 7 80 79 1 −5 −9 8 158 156 2 0 −3 8 147 147 2 −3 3 8126 130 1 2 3 7 15 11 1 −4 10 7 208 211 2 −4 −9 8 110 113 1 1 −3 8 150148 1 −2 3 8 115 114 1 3 3 7 105 109 1 −3 10 7 164 168 2 −3 −9 8 71 75 12 −3 8 181 182 1 −1 3 8 321 314 5 4 3 7 172 166 1 −2 10 7 91 85 2 −2 −98 227 236 1 3 −3 8 76 78 1 0 3 8 148 146 2 5 3 7 75 85 1 0 10 7 94 89 2−1 −9 8 23 22 1 4 −3 8 226 250 4 1 3 8 152 148 1 6 3 7 146 143 1 1 10 754 53 1 0 −9 8 97 98 1 5 −3 8 26 26 1 2 3 8 181 183 1 3 3 8 77 79 1 4 108 30 30 1 −7 −7 9 47 47 1 −1 −1 9 152 144 1 0 5 9 51 50 1 4 3 8 246 2492 −5 11 8 102 103 1 −6 −7 9 47 50 1 0 −1 9 153 158 1 1 5 9 104 111 1 5 38 27 27 1 −4 11 8 33 32 1 −5 −7 9 103 104 2 1 −1 9 179 190 1 2 5 9 93 931 6 3 8 58 60 1 −3 11 8 94 90 2 −4 −7 9 106 105 1 2 −1 9 111 110 1 3 5 960 58 1 −8 4 8 39 38 1 −2 11 8 173 175 3 −3 −7 9 71 69 1 3 −1 9 56 55 14 5 9 126 130 1 −7 4 8 80 80 1 0 11 8 131 133 2 −2 −7 9 170 168 1 4 −1 978 81 1 5 5 9 53 52 1 −6 4 8 46 40 1 1 11 8 58 61 1 −1 −7 9 111 107 1 5−1 9 81 80 1 −6 6 9 31 32 1 −5 4 8 36 29 1 2 11 8 79 79 1 0 −7 9 127 1301 6 −1 9 99 100 1 −5 6 9 155 157 2 −4 4 8 58 55 1 3 11 8 2 7 2 1 −7 9 3337 1 −8 0 9 129 128 2 −4 6 9 64 67 1 −3 4 8 127 133 1 4 11 8 21 26 1 2−7 9 145 144 1 −7 0 9 80 86 1 −3 6 9 37 39 1 −2 4 8 17 19 2 −5 12 8 3129 1 3 −7 9 123 127 2 −6 0 9 124 123 1 −2 6 9 28 33 1 −1 4 8 69 79 2 −412 8 37 40 1 4 −7 9 39 39 1 −5 0 9 151 158 1 −1 6 9 110 111 1 0 4 8 207201 2 −3 12 8 95 93 1 5 −7 9 97 97 1 −4 0 9 132 141 1 0 6 9 219 217 3 14 8 64 62 1 −2 12 8 65 57 1 −7 −6 9 65 58 1 −3 0 9 16 18 1 1 6 9 89 93 12 4 8 151 147 1 0 12 8 19 19 2 −6 −6 9 37 32 1 −2 0 9 160 183 1 2 6 9121 119 1 3 4 8 81 79 1 1 12 8 98 91 1 −5 −6 9 152 156 1 −1 0 9 27 25 13 6 9 68 66 1 4 4 8 106 104 1 2 12 8 44 46 1 −4 −6 9 65 67 1 0 0 9 321321 3 4 6 9 61 61 1 5 4 8 148 147 2 3 12 8 72 73 1 −3 −6 9 37 39 1 1 0 960 65 1 −6 7 9 48 50 1 6 4 8 110 109 2 −4 13 8 44 43 1 −2 −6 9 30 34 1 20 9 171 181 1 −5 7 9 105 104 1 −7 5 8 7 16 7 −3 13 8 39 36 1 −1 −6 9 112111 1 3 0 9 133 137 1 −4 7 9 104 105 1 −6 5 8 36 34 1 −2 13 8 117 120 20 −6 9 222 217 1 4 0 9 59 55 1 −3 7 9 72 70 2 −5 5 8 58 61 1 0 13 8 3736 1 1 −6 9 89 93 1 5 0 9 219 217 4 −2 7 9 167 169 3 −4 5 8 122 121 1 113 8 30 30 1 2 −6 9 125 119 1 6 0 9 104 110 2 −1 7 9 109 107 1 −3 5 8 9395 1 2 13 8 9 8 2 3 −6 9 65 66 1 −8 1 9 37 32 1 0 7 9 127 129 2 −2 5 8104 108 1 −3 14 8 52 56 1 4 −6 9 60 62 1 −7 1 9 86 86 1 1 7 9 35 37 1 −15 8 139 140 1 1 14 8 80 77 1 5 −6 9 49 48 1 −6 1 9 127 126 1 2 7 9 135144 2 0 5 8 108 109 1 −2 −14 9 26 27 1 −7 −5 9 44 41 1 −5 1 9 122 122 13 7 9 126 127 1 1 5 8 105 114 1 −1 −14 9 7 9 2 −6 −5 9 143 148 2 −4 1 947 48 1 4 7 9 38 39 1 2 5 8 137 136 1 0 −14 9 55 51 1 −5 −5 9 91 92 1 −31 9 76 77 1 −6 8 9 80 76 1 3 5 8 66 70 1 −4 −13 9 56 56 1 −4 −5 9 232236 1 −2 1 9 185 186 2 −5 8 9 84 84 1 4 5 8 34 35 1 −3 −13 9 15 14 1 −3−5 9 40 38 1 −1 1 9 152 144 1 −4 8 9 104 108 2 5 5 8 21 19 1 −2 −13 9 4546 1 −2 −5 9 9 13 1 0 1 9 153 158 1 −3 8 9 88 88 1 6 5 8 64 64 1 −1 −139 26 26 1 −1 −5 9 120 115 1 1 1 9 179 190 1 −2 8 9 107 108 2 −7 6 8 5866 1 0 −13 9 96 95 1 0 −5 9 50 49 1 2 1 9 111 110 1 −1 8 9 60 61 1 −6 68 160 166 1 1 −13 9 55 51 1 1 −5 9 104 112 1 3 1 9 57 55 1 0 8 9 115 1212 −5 6 8 64 63 1 2 −13 9 36 36 1 2 −5 9 94 93 1 4 1 9 76 81 1 1 8 9 170169 2 −4 6 8 116 113 1 −4 −12 9 71 71 1 3 −5 9 56 57 1 5 1 9 83 81 1 2 89 184 200 2 −3 6 8 151 150 2 −3 −12 9 102 101 1 4 −5 9 122 130 2 6 1 997 101 1 3 8 9 45 46 1 −2 6 8 45 43 1 −2 −12 9 68 67 1 5 −5 9 51 52 1 −82 9 19 20 1 4 8 9 62 64 1 −1 6 8 86 85 1 −1 −12 9 68 68 1 −7 −4 9 45 451 −7 2 9 64 66 1 −6 9 9 31 32 1 0 6 8 95 100 1 0 −12 9 35 33 1 −6 −4 935 37 1 −6 2 9 51 46 1 −5 9 9 24 23 1 1 6 8 76 73 1 1 −12 9 35 32 1 −5−4 9 259 258 3 −5 2 9 70 73 1 −4 9 9 120 122 1 2 6 8 257 252 3 2 −12 970 64 1 −4 −4 9 50 53 1 −4 2 9 149 150 1 −3 9 9 166 171 2 3 6 8 100 98 1−5 −11 9 40 43 1 −3 −4 9 4 8 4 −3 2 9 130 135 1 −2 9 9 122 120 2 4 6 8107 108 1 −4 −11 9 22 22 1 −2 −4 9 88 85 1 −2 2 9 127 124 1 −1 9 9 313322 6 5 6 8 2 10 2 −3 −11 9 56 55 1 −1 −4 9 131 130 1 −1 2 9 399 391 4 09 9 93 98 2 −6 7 8 147 143 1 −2 −11 9 16 21 1 0 −4 9 209 207 1 0 2 9 151145 1 1 9 9 144 154 2 −5 7 8 20 20 1 −1 −11 9 84 84 1 1 −4 9 176 182 1 12 9 211 208 2 2 9 9 31 30 1 −4 7 8 66 65 1 0 −11 9 83 82 1 2 −4 9 154156 1 2 2 9 228 231 1 3 9 9 51 49 1 −3 7 8 27 33 1 1 −11 9 99 101 1 3 −49 89 87 1 3 2 9 37 40 1 4 9 9 42 39 1 −2 7 8 67 65 1 2 −11 9 138 140 2 4−4 9 69 77 1 4 2 9 58 55 1 −6 10 9 28 26 1 −1 7 8 44 49 1 3 −11 9 48 491 5 −4 9 123 122 2 5 2 9 80 79 1 −5 10 9 41 38 1 0 7 8 126 128 2 −6 −109 29 26 1 −8 −3 9 62 58 1 6 2 9 53 53 1 −4 10 9 122 122 1 1 7 8 148 1461 −5 −10 9 41 38 1 −7 −3 9 66 58 1 −7 3 9 65 59 1 −3 10 9 42 46 1 2 7 877 75 1 −4 −10 9 120 122 1 −5 −3 9 227 224 2 −6 3 9 151 151 1 −2 10 9 6672 2 3 7 8 85 82 1 −3 −10 9 44 45 1 −4 −3 9 154 160 1 −5 3 9 224 223 2 010 9 95 96 2 4 7 8 66 71 1 −2 −10 9 68 71 1 −3 −3 9 61 62 1 −4 3 9 156160 1 1 10 9 100 107 1 −6 8 8 19 17 1 −1 −10 9 89 88 1 −2 −3 9 161 167 1−3 3 9 62 63 1 2 10 9 91 86 1 −5 8 8 36 37 1 0 −10 9 96 96 1 −1 −3 9 3237 1 −2 3 9 162 167 1 3 10 9 64 63 1 −4 8 8 18 20 1 1 −10 9 99 107 1 0−3 9 69 78 1 −1 3 9 32 37 1 4 10 9 46 45 1 −3 8 8 8 13 5 2 −10 9 91 86 11 −3 9 175 181 1 0 3 9 68 77 1 −5 11 9 45 43 1 −2 8 8 188 190 3 3 −10 963 63 1 2 −3 9 141 148 1 1 3 9 176 181 2 −4 11 9 21 22 1 −1 8 8 166 1712 4 −10 9 44 45 1 3 −3 9 47 45 1 2 3 9 143 149 1 −3 11 9 55 55 1 0 8 8161 163 2 −6 −9 9 32 32 1 5 −3 9 165 161 3 3 3 9 49 46 1 −2 11 9 17 20 31 8 8 308 308 4 −5 −9 9 25 23 1 6 −3 9 76 74 1 4 3 9 52 45 1 0 11 9 8183 2 2 8 8 180 186 2 −4 −9 9 123 122 1 −8 −2 9 19 19 1 5 3 9 165 161 3 111 9 98 101 1 3 8 8 135 135 1 −3 −9 9 166 171 1 −7 −2 9 64 66 1 6 3 9 7574 1 2 11 9 143 140 1 4 8 8 128 133 1 −2 −9 9 122 120 1 −6 −2 9 48 46 1−7 4 9 44 44 1 3 11 9 49 50 1 −6 9 8 36 35 1 −1 −9 9 319 322 2 −5 −2 970 73 1 −6 4 9 38 37 1 −4 12 9 71 70 1 −5 9 8 157 156 2 0 −9 9 95 99 1−4 −2 9 148 150 1 −5 4 9 256 257 5 −3 12 9 103 100 1 −4 9 8 109 113 2 1−9 9 144 155 1 −3 −2 9 129 135 1 −4 4 9 49 53 1 −2 12 9 65 66 2 −3 9 872 75 1 2 −9 9 30 29 1 −2 −2 9 128 124 1 −3 4 9 6 8 6 0 12 9 33 33 1 −29 8 232 235 4 3 −9 9 51 50 1 −1 −2 9 407 391 4 −2 4 9 85 85 1 1 12 9 3532 1 0 9 8 98 99 2 4 −9 9 41 39 1 0 −2 9 152 145 1 −1 4 9 127 129 1 2 129 70 64 1 1 9 8 186 188 2 −7 −8 9 19 20 1 1 −2 9 210 207 1 0 4 9 214 2083 −4 13 9 56 57 1 2 9 8 81 86 1 −6 −8 9 78 77 1 2 −2 9 228 231 1 1 4 9178 183 2 −3 13 9 12 13 2 3 9 8 42 41 1 −5 −8 9 87 84 1 3 −2 9 39 40 1 24 9 155 155 1 −2 13 9 44 46 1 4 9 8 59 59 1 −4 −8 9 104 108 1 4 −2 9 5255 1 3 4 9 90 87 1 1 13 9 55 51 1 −6 10 8 44 45 1 −3 −8 9 88 88 1 5 −2 980 78 1 4 4 9 76 77 1 2 13 9 37 36 1 −5 10 8 70 73 1 −2 −8 9 109 109 1 6−2 9 54 53 1 5 4 9 125 123 2 −3 −13 10 27 27 1 −4 10 8 64 69 1 −1 −8 963 62 1 −8 −1 9 37 32 1 −7 5 9 42 41 1 −2 −13 10 32 30 1 −3 10 8 102 991 0 −8 9 113 120 1 −7 −1 9 86 86 1 −6 5 9 146 148 1 −1 −13 10 13 12 1 −210 8 56 58 2 1 −8 9 170 169 1 −6 −1 9 123 127 1 −5 5 9 90 92 2 0 −13 1045 43 1 0 10 8 124 131 2 2 −8 9 199 199 2 −5 −1 9 123 121 1 −4 5 9 242237 3 1 −13 10 38 33 1 1 10 8 72 69 1 3 −8 9 43 47 1 −4 −1 9 48 48 1 −35 9 40 38 1 −4 −12 10 47 47 1 2 10 8 44 50 1 4 −8 9 60 64 1 −3 −1 9 7477 1 −2 5 9 6 13 5 −3 −12 10 75 77 1 3 10 8 115 116 1 5 −8 9 50 50 1 −2−1 9 184 186 1 −1 5 9 118 116 1 −2 −12 10 31 30 1 −1 −12 10 33 33 1 2 −410 91 93 1 −2 3 10 123 121 1 −2 11 10 44 46 2 −3 −4 11 140 143 1 0 −1210 42 44 1 3 −4 10 136 141 2 −1 3 10 19 16 1 0 11 10 100 103 2 −2 −4 1169 65 1 1 −12 10 2 5 2 4 −4 10 69 68 1 0 3 10 189 186 2 1 11 10 116 1201 −1 −4 11 52 47 1 −4 −11 10 63 61 1 5 −4 10 44 41 1 1 3 10 208 214 2 211 10 61 65 1 0 −4 11 32 25 1 −3 −11 10 73 75 1 −7 −3 10 36 36 1 2 3 10152 153 1 3 11 10 30 25 1 1 −4 11 98 104 1 −2 −11 10 44 45 1 −6 −3 10121 121 2 3 3 10 111 113 1 −4 12 10 45 46 1 2 −4 11 201 206 1 −1 −11 1055 53 1 −5 −3 10 287 283 2 4 3 10 104 102 1 −3 12 10 76 77 1 3 −4 11 4343 1 0 −11 10 104 103 1 −4 −3 10 221 223 2 5 3 10 79 80 1 −2 12 10 32 302 4 −4 11 18 20 1 1 −11 10 116 120 1 −3 −3 10 157 159 1 −6 4 10 27 26 10 12 10 42 44 1 −7 −3 11 92 93 1 −5 −10 10 77 79 1 −2 −3 10 122 121 1 −54 10 71 70 1 1 12 10 6 5 5 −6 −3 11 103 102 2 −4 −10 10 74 73 1 −1 −3 1022 16 1 −4 4 10 37 38 1 2 12 10 40 40 1 −5 −3 11 150 148 1 −3 −10 10 5559 1 0 −3 10 187 186 1 −3 4 10 89 85 1 −3 13 10 28 27 1 −4 −3 11 299 3023 −2 −10 10 138 140 1 1 −3 10 207 215 1 −2 4 10 75 76 1 0 13 10 42 43 1−3 −3 11 63 68 1 −1 −10 10 28 31 1 2 −3 10 152 153 1 −1 4 10 182 174 2 113 10 38 33 1 −2 −3 11 119 117 1 0 −10 10 153 150 1 3 −3 10 113 114 1 04 10 152 152 1 −3 −12 11 66 67 1 −1 −3 11 198 203 1 1 −10 10 136 136 1 4−3 10 103 102 2 1 4 10 84 82 1 −2 −12 11 21 21 1 0 −3 11 138 130 1 2 −1010 55 56 1 5 −3 10 78 80 1 2 4 10 90 93 1 −1 −12 11 31 29 1 1 −3 11 188190 2 3 −10 10 13 16 1 −7 −2 10 61 62 1 3 4 10 138 141 1 0 −12 11 68 701 2 −3 11 66 72 1 −6 −9 10 49 48 1 −6 −2 10 76 77 1 4 4 10 69 69 1 1 −1211 53 49 1 3 −3 11 139 141 1 −5 −9 10 97 99 1 −5 −2 10 158 161 1 5 4 1042 41 1 −4 −11 11 73 71 1 4 −3 11 32 33 1 −4 −9 10 69 68 1 −4 −2 10 8289 1 −6 5 10 13 9 1 −3 −11 11 53 54 1 5 −3 11 81 82 1 −3 −9 10 24 19 1−3 −2 10 48 47 1 −5 5 10 41 38 1 −2 −11 11 65 63 1 −7 −2 11 37 34 1 −2−9 10 119 124 1 −2 −2 10 40 40 1 −4 5 10 56 56 1 −1 −11 11 19 24 1 −6 −211 58 60 1 −1 −9 10 38 38 1 −1 −2 10 231 235 2 −3 5 10 104 107 1 0 −1111 52 53 1 −5 −2 11 125 127 1 0 −9 10 216 218 2 0 −2 10 70 69 1 −2 5 10151 151 2 1 −11 11 91 89 1 −4 −2 11 87 90 1 1 −9 10 86 90 1 1 −2 10 176174 1 −1 5 10 71 72 1 −4 −10 11 28 30 1 −3 −2 11 25 26 1 2 −9 10 75 77 12 −2 10 187 187 1 0 5 10 78 83 1 −3 −10 11 128 127 1 −2 −2 11 145 151 13 −9 10 78 74 1 3 −2 10 140 137 1 1 5 10 80 80 1 −2 −10 11 74 71 1 −1 −211 76 77 1 4 −9 10 28 28 1 4 −2 10 71 73 1 2 5 10 100 105 1 −1 −10 11 6863 1 0 −2 11 233 234 2 −6 −8 10 83 80 1 5 −2 10 71 73 1 3 5 10 16 19 1 0−10 11 89 91 1 1 −2 11 116 119 1 −5 −8 10 60 60 1 −7 −1 10 84 83 1 4 510 91 92 1 1 −10 11 104 101 1 2 −2 11 56 60 1 −4 −8 10 93 93 1 −6 −1 10110 112 1 −6 6 10 83 84 1 −4 −9 11 128 129 1 3 −2 11 67 65 1 −3 −8 10 1917 1 −5 −1 10 19 19 1 −5 6 10 176 178 2 −3 −9 11 104 107 1 4 −2 11 123125 2 −2 −8 10 50 53 1 −4 −1 10 70 68 1 −4 6 10 110 116 1 −2 −9 11 133132 1 5 −2 11 71 72 1 −1 −8 10 87 87 1 −3 −1 10 97 97 1 −3 6 10 127 1301 −1 −9 11 93 91 1 −7 −1 11 20 21 1 0 −8 10 157 157 1 −2 −1 10 66 65 1−2 6 10 150 153 2 0 −9 11 49 48 1 −6 −1 11 139 136 1 1 −8 10 18 21 1 −1−1 10 154 153 1 −1 6 10 62 65 1 1 −9 11 117 121 1 −5 −1 11 28 31 1 2 −810 62 63 1 0 −1 10 178 177 1 0 6 10 156 163 2 2 −9 11 82 83 1 −4 −1 11135 130 1 3 −8 10 107 103 2 1 −1 10 43 43 1 1 6 10 117 123 1 3 −9 11 4753 1 −3 −1 11 158 158 1 4 −8 10 43 44 1 2 −1 10 25 26 1 2 6 10 89 98 1−6 −8 11 53 51 1 −2 −1 11 64 66 1 −7 −7 10 44 45 1 3 −1 10 93 91 1 3 610 71 70 1 −5 −8 11 49 50 1 −1 −1 11 10 8 2 −6 −7 10 60 58 1 4 −1 10 6262 1 4 6 10 20 18 1 −4 −8 11 115 117 1 0 −1 11 111 113 1 −5 −7 10 127130 1 5 −1 10 72 73 1 −6 7 10 60 58 1 −3 −8 11 69 70 1 1 −1 11 129 133 1−4 −7 10 46 43 1 −7 0 10 84 82 1 −5 7 10 127 130 1 −2 −8 11 51 49 1 2 −111 100 104 1 −3 −7 10 8 6 3 −6 0 10 23 25 1 −4 7 10 45 43 1 −1 −8 11 117121 1 3 −1 11 35 38 1 −2 −7 10 255 252 1 −5 0 10 23 17 1 −3 7 10 13 6 50 −8 11 125 126 1 4 −1 11 121 117 2 −1 −7 10 186 190 1 −4 0 10 128 134 1−2 7 10 251 252 5 1 −8 11 91 93 1 5 −1 11 34 38 1 0 −7 10 128 132 1 −3 010 181 183 1 −1 7 10 186 190 2 2 −8 11 61 64 1 −7 0 11 35 34 1 1 −7 1083 84 1 −2 0 10 44 49 1 0 7 10 132 132 2 3 −8 11 59 60 1 −6 0 11 133 1291 2 −7 10 98 96 1 −1 0 10 214 206 2 1 7 10 84 84 1 −6 −7 11 69 66 1 −5 011 65 69 1 3 −7 10 48 47 1 0 0 10 159 168 1 2 7 10 91 95 1 −5 −7 11 3535 1 −4 0 11 266 268 3 4 −7 10 49 52 1 1 0 10 101 96 1 3 7 10 50 47 1 −4−7 11 126 128 1 −3 0 11 138 135 1 −7 −6 10 53 47 1 2 0 10 43 39 1 4 7 1048 52 1 −3 −7 11 63 66 1 −2 0 11 73 74 1 −6 −6 10 82 84 1 3 0 10 126 1311 −6 8 10 82 80 1 −2 −7 11 118 120 1 −1 0 11 12 10 2 −5 −6 10 180 178 14 0 10 202 199 3 −5 8 10 59 61 1 −1 −7 11 123 125 1 0 0 11 110 110 1 −4−6 10 111 116 1 5 0 10 39 39 1 −4 8 10 93 93 1 0 −7 11 157 150 1 1 0 1117 10 1 −3 −6 10 127 130 1 −7 1 10 84 82 1 −3 8 10 19 17 2 1 −7 11 36 411 2 0 11 76 78 1 −2 −6 10 155 154 1 −6 1 10 113 112 1 −2 8 10 51 53 2 2−7 11 69 69 1 3 0 11 16 14 1 −1 −6 10 60 65 1 −5 1 10 24 20 1 −1 8 10 8687 2 3 −7 11 29 27 1 4 0 11 8 5 3 0 −6 10 157 163 1 −4 1 10 71 67 1 0 810 156 157 3 4 −7 11 54 56 1 5 0 11 16 17 1 1 −6 10 117 123 1 −3 1 10 9697 1 1 8 10 18 21 1 −6 −6 11 53 52 1 −7 1 11 20 21 1 2 −6 10 96 98 1 −21 10 66 65 1 2 8 10 57 63 1 −5 −6 11 105 97 1 −6 1 11 137 136 1 3 −6 1072 71 1 −1 1 10 155 154 1 3 8 10 105 103 1 −4 −6 11 148 154 1 −5 1 11 3031 1 4 −6 10 22 19 1 0 1 10 177 176 1 4 8 10 44 44 1 −3 −6 11 42 38 1 −41 11 130 130 1 5 −6 10 97 99 1 1 1 10 45 43 1 −6 9 10 49 48 1 −2 −6 11109 111 1 −3 1 11 160 159 1 −7 −5 10 80 80 1 2 1 10 25 27 1 −5 9 10 9898 1 −1 −6 11 69 69 1 −2 1 11 62 66 1 −6 −5 10 13 8 2 3 1 10 89 91 1 −49 10 72 68 1 0 −6 11 134 132 1 −1 1 11 12 9 2 −5 −5 10 38 38 1 4 1 10 6362 1 −3 9 10 22 19 1 1 −6 11 85 85 1 0 1 11 112 112 1 −4 −5 10 56 56 1 51 10 73 73 1 −2 9 10 120 123 2 2 −6 11 83 79 1 1 1 11 130 133 1 −3 −5 10103 106 1 −7 2 10 62 63 1 −1 9 10 41 38 1 3 −6 11 42 38 1 2 1 11 100 1041 −2 −5 10 152 151 1 −6 2 10 77 77 1 0 9 10 215 219 4 4 −6 11 83 89 1 31 11 34 37 1 −1 −5 10 69 73 1 −5 2 10 158 160 1 1 9 10 89 90 1 −7 −5 1151 52 1 4 1 11 119 116 2 0 −5 10 78 82 1 −4 2 10 81 88 1 2 9 10 74 76 1−6 −5 11 96 95 1 5 1 11 36 38 1 1 −5 10 79 80 1 −3 2 10 49 47 1 3 9 1081 74 1 −5 −5 11 76 77 1 −7 2 11 36 35 1 2 −5 10 101 105 1 −2 2 10 38 401 4 9 10 29 28 1 −4 −5 11 75 74 1 −6 2 11 57 60 1 3 −5 10 18 19 1 −1 210 231 236 2 −5 10 10 79 79 1 −3 −5 11 58 58 1 −5 2 11 129 127 1 4 −5 1088 92 1 0 2 10 71 68 1 −4 10 10 74 73 1 −2 −5 11 91 98 1 −4 2 11 86 90 15 −5 10 88 86 1 1 2 10 180 174 2 −3 10 10 56 60 1 −1 −5 11 6 6 5 −3 2 1125 25 1 −7 −4 10 63 59 1 2 2 10 189 186 1 −2 10 10 134 140 3 0 −5 11 142140 1 −2 2 11 145 151 1 −6 −4 10 30 26 1 3 2 10 139 137 1 −1 10 10 34 301 1 −5 11 55 60 1 −1 2 11 77 77 1 −5 −4 10 70 70 1 4 2 10 70 73 1 0 1010 154 150 3 2 −5 11 98 100 1 0 2 11 236 235 2 −4 −4 10 36 38 1 5 2 1070 73 1 1 10 10 137 136 1 3 −5 11 90 89 1 1 2 11 117 119 1 −3 −4 10 9085 1 −7 3 10 34 36 1 2 10 10 59 57 1 4 −5 11 59 59 1 2 2 11 57 59 1 −2−4 10 76 76 1 −6 3 10 120 121 1 3 10 10 17 16 1 −7 −4 11 81 81 1 3 2 1166 65 1 −1 −4 10 183 175 1 −5 3 10 286 282 3 −5 11 10 28 30 1 −6 −4 11123 126 2 4 2 11 121 125 2 0 −4 10 152 153 1 −4 3 10 225 223 3 −4 11 1066 61 1 −5 −4 11 197 198 2 5 2 11 71 72 1 1 −4 10 85 82 1 −3 3 10 157159 1 −3 11 10 73 75 1 −4 −4 11 137 137 1 −6 3 11 104 102 2 −5 3 11 155149 2 −3 12 11 68 67 1 4 −2 12 94 97 1 −4 7 12 135 142 1 −3 −2 13 109114 1 −4 3 11 295 302 4 0 12 11 69 70 1 −7 −1 12 37 34 1 −3 7 12 10 17 4−2 −2 13 76 76 1 −3 3 11 64 67 1 1 12 11 55 49 1 −6 −1 12 80 79 1 −2 712 67 67 2 −1 −2 13 65 65 1 −2 3 11 117 117 1 −3 −11 12 73 75 1 −5 −1 1224 21 1 −1 7 12 119 115 2 0 −2 13 54 54 1 −1 3 11 197 202 2 −2 −11 12 2323 1 −4 −1 12 141 138 2 0 7 12 99 94 1 1 −2 13 48 50 1 0 3 11 141 130 1−1 −11 12 113 109 1 −3 −1 12 63 65 1 1 7 12 22 20 1 2 −2 13 20 17 1 1 311 188 191 2 0 −11 12 60 59 1 −2 −1 12 117 120 1 2 7 12 61 61 1 −6 −1 1348 45 1 2 3 11 66 73 1 −4 −10 12 60 57 1 −1 −1 12 64 67 1 3 7 12 101 981 −5 −1 13 71 72 1 3 3 11 139 141 1 −3 −10 12 46 47 1 0 −1 12 29 31 1 −58 12 95 96 1 −4 −1 13 58 57 1 4 3 11 33 34 1 −2 −10 12 92 87 1 1 −1 1276 75 1 −4 8 12 50 47 1 −3 −1 13 163 164 1 −6 4 11 126 127 1 −1 −10 12122 121 1 2 −1 12 25 28 1 −3 8 12 173 177 1 −2 −1 13 26 23 1 −5 4 11 197198 2 0 −10 12 53 50 1 3 −1 12 37 34 1 −2 8 12 166 161 3 −1 −1 13 109106 1 −4 4 11 131 136 1 1 −10 12 81 78 1 4 −1 12 36 34 1 −1 8 12 50 53 10 −1 13 108 108 1 −3 4 11 140 144 1 −4 −9 12 109 102 1 −6 0 12 74 76 1 08 12 72 70 1 1 −1 13 70 68 1 −2 4 11 70 65 1 −3 −9 12 26 25 1 −5 0 12 5051 1 1 8 12 91 87 1 2 −1 13 40 39 1 −1 4 11 51 47 1 −2 −9 12 62 61 1 −40 12 54 49 1 2 8 12 76 73 1 −6 0 13 62 60 1 0 4 11 34 25 1 −1 −9 12 8184 1 −3 0 12 156 161 1 −5 9 12 10 13 2 −5 0 13 88 85 1 1 4 11 97 104 1 0−9 12 39 40 1 −2 0 12 110 106 1 −4 9 12 111 102 1 −4 0 13 13 1 2 2 4 11205 206 2 1 −9 12 60 59 1 −1 0 12 46 52 1 −3 9 12 28 25 1 −3 0 13 48 511 3 4 11 43 42 1 −4 −8 12 50 47 1 0 0 12 186 187 2 −2 9 12 60 61 2 −2 013 25 24 1 4 4 11 18 20 1 −3 −8 12 175 177 1 1 0 12 25 27 1 −1 9 12 8084 2 −1 0 13 72 75 1 −6 5 11 97 95 1 −2 −8 12 163 161 1 2 0 12 91 91 1 09 12 38 39 1 0 0 13 44 48 1 −5 5 11 76 77 2 −1 −8 12 52 53 1 3 0 12 6062 1 1 9 12 60 59 1 1 0 13 41 44 1 −4 5 11 71 74 1 0 −8 12 72 69 1 4 012 38 41 1 2 9 12 6 4 5 2 0 13 30 30 1 −3 5 11 58 59 1 1 −8 12 89 87 1−6 1 12 77 78 1 −4 10 12 60 57 1 3 0 13 12 11 1 −2 5 11 92 98 1 −4 −7 12136 143 1 −5 1 12 25 21 1 −3 10 12 44 46 1 −6 1 13 46 45 1 −1 5 11 6 5 5−3 −7 12 16 17 1 −4 1 12 140 138 2 −2 10 12 88 87 2 −5 1 13 71 72 1 0 511 143 140 1 −2 −7 12 66 68 1 −3 1 12 63 65 1 −1 10 12 118 121 2 −4 1 1357 57 1 1 5 11 56 60 1 −1 −7 12 118 115 1 −2 1 12 119 120 1 0 10 12 5250 1 −3 1 13 166 164 1 2 5 11 99 100 1 0 −7 12 98 94 1 −1 1 12 65 67 1 110 12 80 77 1 −2 1 13 25 24 1 3 5 11 90 89 1 1 −7 12 24 20 1 0 1 12 3131 1 −3 11 12 73 75 1 −1 1 13 110 106 1 4 5 11 59 59 1 2 −7 12 63 62 1 11 12 74 75 1 0 11 12 60 59 1 0 1 13 113 108 2 −6 6 11 51 52 1 3 −7 12 9798 2 2 1 12 27 29 1 −3 −10 13 25 23 1 1 1 13 70 68 1 −5 6 11 104 98 1 −6−6 12 91 94 1 3 1 12 37 33 1 −2 −10 13 21 19 1 2 1 13 39 39 1 −4 6 11147 153 2 −5 −6 12 88 84 1 4 1 12 36 34 1 −1 −10 13 128 124 1 3 1 13 2221 1 −3 6 11 41 38 1 −4 −6 12 98 97 1 −6 2 12 82 81 1 0 −10 13 45 43 1−6 2 13 106 107 2 −2 6 11 110 111 2 −3 −6 12 73 73 1 −5 2 12 69 69 1 −4−9 13 76 75 1 −5 2 13 31 29 1 −1 6 11 71 69 1 −2 −6 12 84 78 1 −4 2 1272 74 1 −3 −9 13 151 147 1 −4 2 13 145 147 2 0 6 11 135 132 1 −1 −6 1274 74 1 −3 2 12 115 109 1 −2 −9 13 68 66 1 −3 2 13 112 113 1 1 6 11 8685 1 0 −6 12 117 114 1 −2 2 12 57 59 1 −1 −9 13 38 35 1 −2 2 13 79 77 12 6 11 83 79 1 1 −6 12 57 57 1 −1 2 12 55 55 1 0 −9 13 75 71 1 −1 2 1366 66 1 3 6 11 43 38 1 2 −6 12 81 78 1 0 2 12 224 227 2 1 −9 13 34 32 10 2 13 56 54 1 4 6 11 86 89 1 3 −6 12 78 76 1 1 2 12 120 128 1 −4 −8 13115 115 1 1 2 13 47 49 1 −6 7 11 70 66 1 −6 −5 12 135 138 2 2 2 12 102101 1 −3 −8 13 49 46 1 2 2 13 22 18 1 −5 7 11 31 35 1 −5 −5 12 176 175 33 2 12 84 84 1 −2 −8 13 114 109 1 3 2 13 51 51 1 −4 7 11 125 128 1 −4 −512 25 23 1 −6 3 12 15 11 2 −1 −8 13 45 48 1 −6 3 13 55 53 1 −3 7 11 6166 2 −3 −5 12 65 63 1 −5 3 12 97 95 1 0 −8 13 19 20 1 −5 3 13 109 106 1−2 7 11 122 119 2 −2 −5 12 67 67 1 −4 3 12 59 67 2 1 −8 13 90 84 1 −4 313 39 42 1 −1 7 11 124 126 2 −1 −5 12 25 28 1 −3 3 12 154 161 1 −4 −7 1399 98 1 −3 3 13 98 95 1 0 7 11 156 150 2 0 −5 12 100 97 1 −2 3 12 79 771 −3 −7 13 61 60 1 −2 3 13 42 39 1 1 7 11 34 41 1 1 −5 12 137 141 1 −1 312 220 217 3 −2 −7 13 35 36 1 −1 3 13 69 64 1 2 7 11 68 69 1 2 −5 12 9292 1 0 3 12 179 174 2 −1 −7 13 64 60 1 0 3 13 191 199 3 3 7 11 25 28 1 3−5 12 53 54 1 1 3 12 80 90 1 0 −7 13 95 95 1 1 3 13 72 74 1 4 7 11 57 571 4 −5 12 13 13 1 2 3 12 68 67 1 1 −7 13 42 42 1 2 3 13 69 66 1 −6 8 1150 51 1 −6 −4 12 120 122 2 3 3 12 129 132 1 −5 −6 13 38 39 1 3 3 13 9896 1 −5 8 11 51 50 1 −5 −4 12 54 55 1 −6 4 12 117 122 1 −4 −6 13 108 1081 −6 4 13 28 31 1 −4 8 11 115 117 1 −4 −4 12 122 121 1 −5 4 12 54 54 1−3 −6 13 94 91 1 −5 4 13 105 105 2 −3 8 11 67 71 1 −3 −4 12 138 140 1 −44 12 114 121 1 −2 −6 13 6 8 4 −4 4 13 106 103 1 −2 8 11 51 49 2 −2 −4 12132 128 1 −3 4 12 140 140 1 −1 −6 13 20 19 1 −3 4 13 87 84 1 −1 8 11 119121 2 −1 −4 12 79 85 1 −2 4 12 134 129 1 0 −6 13 25 24 1 −2 4 13 106 1091 0 8 11 123 125 1 0 −4 12 125 119 1 −1 4 12 80 84 1 1 −6 13 91 96 1 −14 13 123 111 1 1 8 11 92 93 1 1 −4 12 103 103 1 0 4 12 131 119 1 −5 −513 139 137 2 0 4 13 144 146 1 2 8 11 61 64 1 2 −4 12 47 48 1 1 4 12 94103 1 −4 −5 13 88 87 1 1 4 13 72 73 1 3 8 11 58 61 1 3 −4 12 45 49 1 2 412 47 48 1 −3 −5 13 29 25 1 2 4 13 102 102 1 −5 9 11 114 111 1 4 −4 1220 22 1 3 4 12 47 49 1 −2 −5 13 122 126 1 3 4 13 46 44 1 −4 9 11 129 1291 −6 −3 12 15 11 2 −6 5 12 136 138 1 −1 −5 13 63 66 1 −6 5 13 55 57 1 −39 11 105 108 1 −5 −3 12 97 96 1 −5 5 12 181 175 3 0 −5 13 120 116 1 −5 513 140 137 2 −2 9 11 132 132 2 −4 −3 12 67 67 1 −4 5 12 26 23 1 1 −5 1356 56 1 −4 5 13 89 87 1 −1 9 11 91 91 2 −3 −3 12 150 162 1 −3 5 12 64 631 2 −5 13 18 15 1 −3 5 13 28 25 1 0 9 11 50 47 1 −2 −3 12 78 77 1 −2 512 66 66 1 −5 −4 13 100 105 2 −2 5 13 120 126 1 1 9 11 117 121 1 −1 −312 220 218 2 −1 5 12 25 28 1 −4 −4 13 106 104 1 −1 5 13 64 66 1 2 9 1183 83 1 0 −3 12 173 174 1 0 5 12 104 98 1 −3 −4 13 85 83 1 0 5 13 120116 1 3 9 11 50 53 1 1 −3 12 91 90 1 1 5 12 134 142 1 −2 −4 13 107 108 11 5 13 57 56 1 −5 10 11 25 23 1 2 −3 12 67 67 1 2 5 12 91 91 1 −1 −4 13123 112 1 2 5 13 19 16 1 −4 10 11 29 30 1 3 −3 12 126 131 2 3 5 12 53 531 0 −4 13 142 146 1 3 5 13 52 53 1 −3 10 11 125 126 2 4 −3 12 49 52 1 −66 12 94 95 1 1 −4 13 73 74 1 −5 6 13 40 38 1 −2 10 11 71 71 2 −7 −2 1292 89 1 −5 6 12 88 84 1 2 −4 13 102 102 1 −4 6 13 113 108 1 −1 10 11 6563 1 −6 −2 12 81 82 1 −4 6 12 97 97 1 −5 −3 13 107 106 1 −3 6 13 94 90 10 10 11 88 91 1 −5 −2 12 67 68 1 −3 6 12 73 74 1 −4 −3 13 41 42 1 −2 613 9 8 5 1 10 11 106 101 1 −4 −2 12 74 74 1 −2 6 12 86 78 2 −3 −3 13 9094 1 −1 6 13 19 19 2 2 10 11 84 88 1 −3 −2 12 112 108 1 −1 6 12 74 74 1−2 −3 13 40 39 1 0 6 13 25 24 1 −4 11 11 72 71 1 −2 −2 12 56 59 1 0 6 12118 113 1 −1 −3 13 67 64 1 1 6 13 93 96 1 −3 11 11 51 55 1 −1 −2 12 5455 1 1 6 12 57 57 1 0 −3 13 187 199 1 2 6 13 37 33 1 −2 11 11 68 63 1 0−2 12 224 228 2 2 6 12 81 78 1 1 −3 13 74 74 1 3 6 13 16 15 1 0 11 11 5253 1 1 −2 12 126 128 1 3 6 12 81 76 1 2 −3 13 69 66 1 −5 7 13 115 114 11 11 11 91 89 1 2 −2 12 98 101 1 −6 7 12 106 105 2 −5 −2 13 29 30 1 −4 713 104 98 1 2 11 11 60 62 1 3 −2 12 85 84 1 −5 7 12 83 80 1 −4 −2 13 147146 2 −3 7 13 61 60 1 −2 7 13 38 35 2 −3 −3 14 21 20 1 2 3 14 50 49 1 −5−3 15 70 72 1 0 4 15 88 84 1 −1 7 13 63 60 1 −2 −3 14 87 83 1 −5 4 14 6264 1 −4 −3 15 39 37 1 1 4 15 16 15 1 0 7 13 95 94 1 −1 −3 14 34 34 1 −44 14 97 92 1 −3 −3 15 33 36 1 −4 5 15 70 72 1 1 7 13 43 41 1 0 −3 14 9090 1 −3 4 14 37 33 1 −2 −3 15 22 20 1 −3 5 15 34 26 1 2 7 13 38 35 1 1−3 14 112 107 1 −2 4 14 96 97 1 −1 −3 15 37 35 1 −2 5 15 11 5 2 −4 8 13118 114 1 2 −3 14 51 49 1 −1 4 14 85 81 1 0 −3 15 55 53 1 −1 5 15 77 771 −3 8 13 49 46 1 −5 −2 14 40 39 1 0 4 14 118 110 1 1 −3 15 35 30 1 0 515 38 36 1 −2 8 13 111 108 2 −4 −2 14 164 161 2 1 4 14 72 75 1 −5 −2 1551 51 1 1 5 15 109 110 1 −1 8 13 43 47 1 −3 −2 14 207 202 2 2 4 14 73 761 −4 −2 15 31 30 1 −3 6 15 54 60 1 0 8 13 19 20 1 −2 −2 14 75 77 1 −5 514 37 34 1 −3 −2 15 116 120 1 −2 6 15 25 24 1 1 8 13 89 84 1 −1 −2 14 6666 1 −4 5 14 98 95 1 −2 −2 15 72 68 1 −1 6 15 35 36 1 2 8 13 83 81 1 0−2 14 85 86 1 −3 5 14 21 22 1 −1 −2 15 83 87 1 0 6 15 37 36 1 −4 9 13 7375 1 1 −2 14 84 83 1 −2 5 14 84 82 1 0 −2 15 155 149 2 −3 7 15 51 47 1−3 9 13 147 147 2 2 −2 14 34 37 1 −1 5 14 74 69 1 1 −2 15 44 46 1 −2 715 77 80 1 −2 9 13 68 67 1 −5 −1 14 81 85 1 0 5 14 57 57 1 −5 −1 15 2630 1 −1 7 15 14 11 2 −1 9 13 36 35 1 −4 −1 14 117 117 1 1 5 14 70 70 1−4 −1 15 85 86 1 −3 −4 16 43 42 1 0 9 13 75 71 1 −3 −1 14 47 44 1 2 5 1449 47 1 −3 −1 15 56 57 1 −2 −4 16 49 51 1 1 9 13 35 32 1 −2 −1 14 26 261 −5 6 14 62 62 1 −2 −1 15 31 34 1 −1 −4 16 30 29 1 −3 10 13 24 23 1 −1−1 14 78 76 1 −4 6 14 125 120 1 −1 −1 15 149 147 1 −3 −3 16 12 10 1 −110 13 125 125 1 0 −1 14 149 148 1 −3 6 14 105 102 1 0 −1 15 40 40 1 −2−3 16 24 25 1 0 10 13 45 43 1 1 −1 14 48 51 1 −2 6 14 28 27 1 1 −1 15 3736 1 −1 −3 16 49 50 1 −2 −9 14 64 69 1 2 −1 14 17 15 1 −1 6 14 64 62 1 2−1 15 55 54 1 0 −3 16 45 43 1 −1 −9 14 52 49 1 −5 0 14 38 37 1 0 6 14 2822 1 −5 0 15 45 45 1 −4 −2 16 40 41 1 −3 −8 14 26 25 1 −4 0 14 17 19 2 16 14 55 53 1 −4 0 15 80 82 1 −3 −2 16 34 30 1 −2 −8 14 66 64 1 −3 0 1443 42 1 2 6 14 126 129 2 −3 0 15 14 9 1 −2 −2 16 54 57 1 −1 −8 14 34 331 −2 0 14 95 97 1 −4 7 14 29 30 1 −2 0 15 42 48 1 −1 −2 16 60 57 1 0 −814 85 83 1 −1 0 14 132 132 1 −3 7 14 90 83 1 −1 0 15 5 4 5 0 −2 16 117118 1 −4 −7 14 30 30 1 0 0 14 81 76 1 −2 7 14 129 129 2 0 0 15 10 12 3−4 −1 16 89 86 1 −3 −7 14 89 83 1 1 0 14 62 60 1 −1 7 14 33 36 1 1 0 1512 14 1 −3 −1 16 78 78 1 −2 −7 14 130 129 1 2 0 14 4 2 4 0 7 14 66 64 12 0 15 54 48 1 −2 −1 16 12 13 1 −1 −7 14 32 36 1 −6 1 14 59 60 1 1 7 1415 15 1 −5 1 15 26 30 1 −1 −1 16 104 100 1 0 −7 14 67 64 1 −5 1 14 83 851 −3 8 14 27 26 1 −4 1 15 86 86 1 0 −1 16 129 129 1 1 −7 14 15 16 1 −4 114 117 117 1 −2 8 14 66 64 1 −3 1 15 57 57 1 −4 0 16 106 108 1 −4 −6 14120 120 1 −3 1 14 47 44 1 −1 8 14 34 32 1 −2 1 15 34 34 1 −3 0 16 4 6 4−3 −6 14 103 102 1 −2 1 14 25 26 1 0 8 14 85 82 1 −1 1 15 150 147 1 −2 016 40 35 1 −2 −6 14 28 27 1 −1 1 14 79 76 1 −1 9 14 53 49 1 0 1 15 41 401 −1 0 16 32 33 1 −1 −6 14 66 63 1 0 1 14 150 148 2 −3 −7 15 50 47 1 1 115 35 36 1 0 0 16 30 30 1 0 −6 14 27 22 1 1 1 14 47 51 1 −2 −7 15 77 801 2 1 15 53 53 1 −4 1 16 86 86 1 1 −6 14 59 53 1 2 1 14 15 16 1 −1 −7 1510 11 1 −5 2 15 50 51 1 −3 1 16 79 79 1 −5 −5 14 36 34 1 −6 2 14 21 23 1−3 −6 15 55 60 1 −4 2 15 27 29 1 −2 1 16 13 13 1 −4 −5 14 96 95 1 −5 214 42 40 1 −2 −6 15 26 24 1 −3 2 15 118 119 1 −1 1 16 103 100 1 −3 −5 1425 22 1 −4 2 14 164 160 1 −1 −6 15 35 35 1 −2 2 15 72 68 1 0 1 16 128129 1 −2 −5 14 86 82 1 −3 2 14 209 202 2 0 −6 15 36 36 1 −1 2 15 83 87 1−4 2 16 42 41 1 −1 −5 14 76 69 1 −2 2 14 75 76 1 −4 −5 15 75 73 1 0 2 15156 149 2 −3 2 16 36 30 1 0 −5 14 54 57 1 −1 2 14 66 66 1 −3 −5 15 30 261 1 2 15 47 47 1 −2 2 16 54 57 1 1 −5 14 71 71 1 0 2 14 87 87 1 −2 −5 159 5 1 −4 3 15 41 37 1 −1 2 16 60 56 1 −5 −4 14 64 65 1 1 2 14 83 83 1 −1−5 15 77 77 1 −3 3 15 35 36 1 0 2 16 117 118 1 −4 −4 14 94 92 1 2 2 1433 37 1 0 −5 15 39 35 1 −2 3 15 19 19 1 −3 3 16 13 11 4 −3 −4 14 35 33 1−5 3 14 27 22 1 1 −5 15 110 110 2 −1 3 15 38 35 1 −2 3 16 25 25 1 −2 −414 98 97 1 −4 3 14 34 32 1 −4 −4 15 21 21 1 0 3 15 56 53 1 −1 3 16 49 491 −1 −4 14 86 80 1 −3 3 14 20 20 1 −3 −4 15 8 9 3 1 3 15 35 30 1 0 3 1645 43 1 0 −4 14 118 111 1 −2 3 14 85 83 1 −2 −4 15 35 32 1 −4 4 15 22 211 −3 4 16 42 42 1 1 −4 14 72 75 1 −1 3 14 34 34 1 −1 −4 15 38 37 1 −3 415 10 9 1 −2 4 16 49 51 1 −5 −3 14 21 22 1 0 3 14 91 90 1 0 −4 15 86 841 −2 4 15 34 32 1 −1 4 16 29 29 1 −4 −3 14 32 32 1 1 3 14 113 107 1 1 −415 14 15 2 −1 4 15 39 37 1

TABLE 9 Crystal data and structure refinement for MET-2. Empiricalformula C32H56O4 Formula weight 504.77 Temperature 298(1) K Wavelength1.54178 Å Crystal system, space group Monoclinic, C2 Unit celldimensions a = 27.3382(16) Å α = 90° b = 6.6860(13) Å β = 113.57(3)° c =19.221(10) A γ = 90° Volume 3320.3(11) Å³ Z 4 Calculated density 1.041Mg/m³ Absorption coefficient 0.513 mm⁻¹ F(000) 1120 Crystal size 0.36 ×0.17 × 0.03 mm Theta range for data collection 2.51 to 58.69° Limitingindices −29 <= h <= 28, −6 <= k <= 6, −21 <= l <= 21 Reflectionscollected/unique 10383/3985 [R(int) = 0.0473] Data/restraints/parameters3985/1/325 Goodness-of-fit on F² 1.073 Final R indices [I > 2σ(I)] R1 =0.0618, wR2 = 0.1600 R indices (all data) R1 = 0.0844, wR2 = 0.1778Absolute structure parameter 0.2(4) Largest diff. peak and hole 0.140and −0.190 e/Å⁻³

TABLE 10 Atomic coordinates (Å² × 10⁴) and equivalent isotropicdisplacement parameters (Å² × 10³) for MET-2 U(eq) is defined as onethird of the trace of the orthogonalized Uij tensor. x y z U(eq) O(3)9651(1) 8018(5) 3345(2) 80(1) C(20) 7634(1) 8343(6) −2763(2) 67(1) O(25)9328(1) 7952(6) −3391(2) 102(1) C(13) 7985(1) 7574(6) −1301(2) 59(1)C(1) 9449(2) 12075(6)  2708(2) 66(1) C(17) 8118(1) 8204(6) −1982(2)59(1) O(1) 9565(1) 14167(5)  2735(2) 88(1) C(10) 8922(2) 11685(7) 2036(2) 73(1) C(23) 8253(2) 8546(7) −3469(2) 70(1) C(2) 9409(2)11384(7)  3438(2) 67(1) C(12) 7838(2) 5387(7) −1291(2) 74(1) C(14)8539(1) 7926(6) −637(2) 64(1) C(22) 7766(2) 7484(7) −3431(2) 69(1) C(18)7564(2) 8908(7) −1201(3) 79(1) C(5) 8739(2) 9568(7) 2011(2) 68(1) C(3)9242(2) 9248(7) 3413(2) 68(1) C(15) 8704(2) 9975(8) −812(2) 77(1) C(9)8370(2) 5285(7) 139(2) 83(1) C(16) 8471(2) 10076(7)  −1687(2) 76(1)C(25) 8924(2)  8719(10) −4091(2) 93(2) C(8) 8525(2) 7441(7) 118(2) 69(1)C(30) 7870(2) 5245(7) −3306(3) 98(2) C(28) 7279(2)  7779(10) −4185(2)103(2) C(24) 8394(2)  7945(10) −4124(2) 91(2) C(11) 7843(2) 4765(8)−517(2) 83(1) C(4) 8712(2) 8882(8) 2740(2) 74(1) C(27) 8974(2) 10999(12)−4028(4) 134(3) C(6) 8624(1) 8330(8) 1421(2) 72(1) C(21) 7379(2)10414(8)  −2945(3) 98(2) C(26) 9029(2)  7983(18) −4745(3) 177(4) C(7)8639(2) 8753(7) 686(2) 72(1) C(29) 9490(2) 12565(9)  4016(2) 97(2)O(201) 10425(1) 14824(6)  2396(2) 112(1) C(202) 10381(3) 15282(14)1660(3) 128(2) C(201) 10109(4) 17151(16) 1381(5) 185(4) C(203) 10130(5)13539(17) 1161(5) 223(5)

TABLE 11 Bond lengths [Å] for MET-2. O(3)—C(3) 1.434(5) C(20)—C(21)1.527(6) C(20)—C(17) 1.558(5) C(20)—C(22) 1.573(5) O(25)—C(25) 1.451(5)C(13)—C(12) 1.518(6) C(13)—C(18) 1.527(6) C(13)—C(17) 1.549(5)C(13)—C(14) 1.560(5) C(1)—O(1) 1.431(5) C(1)—C(2) 1.521(5) C(1)—C(10)1.524(6) C(17)—C(16) 1.543(6) C(10)—C(5) 1.495(6) C(23)—C(24) 1.511(5)C(23)—C(22) 1.535(6) C(2)—C(29) 1.308(6) C(2)—C(3) 1.495(6) C(12)—C(11)1.541(5) C(14)—C(8) 1.501(5) C(14)—C(15) 1.522(6) C(22)—C(30) 1.524(7)C(22)—C(28) 1.541(6) C(5)—C(6) 1.336(6) C(5)—C(4) 1.505(5) C(3)—C(4)1.527(5) C(15)—C(16) 1.543(5) C(9)—C(8) 1.508(7) C(9)—C(11) 1.527(6)C(25)—C(26) 1.483(8) C(25)—C(24) 1.516(7) C(25)—C(27) 1.532(9) C(8)—C(7)1.336(6) C(6)—C(7) 1.458(5) O(201)—C(202) 1.405(7) C(202)—C(201)1.443(11) C(202)—C(203) 1.490(11)

TABLE 12 bond angles [°] for MET-2. C(21)—C(20)—C(17) 114.1(3)C(21)—C(20)—C(22) 112.2(4) C(17)—C(20)—C(22) 112.4(3) C(12)—C(13)—C(18)110.1(3) C(12)—C(13)—C(17) 115.2(3) C(18)—C(13)—C(17) 113.0(3)C(12)—C(13)—C(14) 108.1(3) C(18)—C(13)—C(14) 110.0(3) C(17)—C(13)—C(14)99.8(3) O(1)—C(1)—C(2) 111.1(3) O(1)—C(1)—C(10) 108.7(4) C(2)—C(1)—C(10)109.7(3) C(16)—C(17)—C(13) 103.5(3) C(16)—C(17)—C(20) 118.1(3)C(13)—C(17)—C(20) 115.7(3) C(5)—C(10)—C(1) 112.3(3) C(24)—C(23)—C(22)115.5(4) C(29)—C(2)—C(3) 123.4(4) C(29)—C(2)—C(1) 123.4(4)C(3)—C(2)—C(1) 113.2(3) C(13)—C(12)—C(11) 111.8(3) C(8)—C(14)—C(15)122.2(3) C(8)—C(14)—C(13) 111.5(3) C(15)—C(14)—C(13) 103.4(3)C(30)—C(22)—C(23) 110.6(4) C(30)—C(22)—C(28) 108.1(4) C(23)—C(22)—C(28)109.6(3) C(30)—C(22)—C(20) 108.7(3) C(23)—C(22)—C(20) 110.8(3)C(28)—C(22)—C(20) 109.1(3) C(6)—C(5)—C(10) 125.2(4) C(6)—C(5)—C(4)121.3(4) C(10)—C(5)—C(4) 113.5(4) O(3)—C(3)—C(2) 108.1(3) O(3)—C(3)—C(4)109.9(3) C(2)—C(3)—C(4) 110.8(4) C(14)—C(15)—C(16) 104.5(3)C(8)—C(9)—C(11) 112.2(4) C(17)—C(16)—C(15) 106.9(3) O(25)—C(25)—C(26)109.6(5) O(25)—C(25)—C(24) 106.2(4) C(26)—C(25)—C(24) 111.0(5)O(25)—C(25)—C(27) 105.5(5) C(26)—C(25)—C(27) 110.8(6) C(24)—C(25)—C(27)113.4(5) C(7)—C(8)—C(14) 124.1(4) C(7)—C(8)—C(9) 125.5(4)C(14)—C(8)—C(9) 110.4(3) C(23)—C(24)—C(25) 115.6(4) C(9)—C(11)—C(12)112.2(3) C(5)—C(4)—C(3) 110.9(3) C(5)—C(6)—C(7) 127.9(4) C(8)—C(7)—C(6)125.2(4) O(201)—C(202)—C(201) 112.8(6) O(201)—C(202)—C(203) 108.1(7)C(201)—C(202)—C(203) 113.8(7)

TABLE 13 Anisotropic displacement parameters (Å² × 10³) for MET-2. Theanisotropic displacement factor exponent takes the form “−2π²[h²a *2U₁₁ + + 2hka * b * U₁₂] U₁₁ U₂₂ U₃₃ U₂₃ U₁₃ U₁₂ O(3) 67(2) 71(2) 93(2) −5(2) 22(1)  −7(2) C(20) 58(2) 70(3) 67(2)  −4(2) 20(2)  −6(2) O(25)79(2) 144(3)  86(2)  43(2) 36(2)  34(2) C(13) 63(2) 53(3) 67(2) −10(2)31(2)  −4(2) C(1) 73(3) 52(3) 75(3)  −5(2) 31(2)  −8(2) C(17) 53(2)65(3) 60(2) −10(2) 23(2) −12(2) O(1) 102(2)  67(2) 87(2) −11(2) 31(2)−14(2) C(10) 76(3) 76(3) 60(2)  −6(2) 18(2)  −3(2) C(23) 65(2) 79(3)65(2)  −1(2) 25(2)  −7(2) C(2) 62(2) 73(3) 63(2)  −7(2) 21(2)  −5(2)C(12) 88(3) 74(3) 65(2) −12(2) 37(2) −23(2) C(14) 65(2) 65(3) 63(2) −9(2) 27(2) −11(2) C(22) 61(2) 79(3) 64(2)  −9(2) 21(2) −16(2) C(18)68(2) 86(3) 91(3) −20(2) 38(2)  −8(2) C(5) 54(2) 82(3) 58(2)  −6(2)14(2) −13(2) C(3) 68(2) 76(3) 59(2)  −4(2) 24(2)  −9(2) C(15) 78(3)82(3) 71(2) −11(2) 30(2) −23(3) C(9) 106(3)  76(3) 68(2)  −4(2) 38(2)−11(3) C(16) 73(3) 80(3) 73(2)  −7(2) 26(2) −26(2) C(25) 68(3) 146(6) 64(3)  17(3) 24(2)  3(3) C(8) 66(2) 72(3) 65(2)  −4(2) 22(2)  −6(2)C(30) 152(5)  58(3) 103(3)  −15(3) 70(3) −17(3) C(28) 76(3) 148(5) 71(3)  −6(3) 16(2) −18(3) C(24) 81(3) 129(5)  65(2)  −4(3) 31(2) −11(3)C(11) 108(3)  78(3) 76(3) −16(2) 49(3) −37(3) C(4) 60(2) 97(4) 67(2) −2(2) 28(2) −14(2) C(27) 75(4) 156(7)  150(5)   72(5) 22(3) −12(4) C(6)60(2) 84(3) 67(2)  −7(2) 20(2) −19(2) C(21) 88(3) 94(4) 103(3)   10(3)26(3)  32(3) C(26) 137(5)  337(12) 83(3)  −5(6) 72(4) −23(7) C(7) 65(2)81(3) 60(2)  −4(2) 15(2) −17(2) C(29) 125(4)  92(4) 69(3) −10(3) 35(3) −8(3) O(201) 123(3)  122(3)  96(2) −17(2) 51(2) −23(2) C(202) 113(4) 180(8)  101(4)   −8(5) 54(4) −21(5) C(201) 192(8)  180(9)  152(7)  42(6) 36(6)  15(8) C(203) 305(13) 227(11) 134(6)  −84(7) 85(7)  −25(10)

TABLE 14 Hydrogen coordinates (Å² × 10⁴) and isotropic displacementparameters (Å² × 10³) for MET-2. x y z U(eq) H(3A) 9521 6950 3147 120H(20I) 7360 7457 −2725 80 H(25A) 9621 8007 −3413 153 H(1A) 9733 113262636 79 H(17A) 8352 7159 −2035 71 H(1B) 9853 14390 3088 131 H(10A) 865112572 2069 88 H(10B) 8963 11988 1569 88 H(23A) 8187 9976 −3499 84 H(23B)8559 8290 −2999 84 H(12A) 8088 4563 −1405 88 H(12B) 7484 5157 −1683 88H(14A) 8784 6962 −710 77 H(18A) 7495 8444 −777 119 H(18B) 7241 8859−1653 119 H(18C) 7693 10260 −1111 119 H(3B) 9203 8917 3885 82 H(15A)9090 10101 −603 92 H(15B) 8558 11029 −605 92 H(9A) 8338 5027 616 99H(9B) 8649 4428 116 99 H(16A) 8260 11280 −1864 92 H(16B) 8756 10086−1867 92 H(30A) 7954 4704 −3709 147 H(30B) 7558 4597 −3304 147 H(30C)8165 5024 −2829 147 H(28A) 7358 7266 −4595 154 H(28B) 7197 9178 −4264154 H(28C) 6978 7076 −4166 154 H(24A) 8114 8414 −4591 109 H(24B) 83986496 −4147 109 H(11A) 7553 5434 −441 100 H(11B) 7783 3335 −517 100 H(4A)8627 7467 2706 89 H(4B) 8430 9599 2818 89 H(27A) 9317 11395 −4006 201H(27B) 8937 11432 −3575 201 H(27C) 8699 11600 −4462 201 H(6A) 8522 70411487 87 H(21A) 7302 10877 −2527 148 H(21B) 7054 10341 −3393 148 H(21C)7620 11328 −3030 148 H(26A) 8994 6554 −4776 265 H(26B) 9385 8347 −4679265 H(26C) 8778 8571 −5205 265 H(7A) 8736 10038 606 86 H(29A) 9444 120864440 116 H(29B) 9594 13885 4003 116 H(20A) 10540 15801 2672 167 H(20B)10744 15418 1682 154 H(20C) 10300 18216 1714 278 H(20D) 9753 17079 1362278 H(20E) 10094 17402 881 278 H(20F) 10095 13823 653 334 H(20G) 978413292 1161 334 H(20H) 10351 12378 1348 334

TABLE 15 Torsion angles [deg] for MET-2. C(12)—C(13)—C(17)—C(16)−156.5(4) C(18)—C(13)—C(17)—C(16) 75.8(4) C(14)—C(13)—C(17)—C(16)−41.0(4) C(12)—C(13)—C(17)—C(20) 72.7(5) C(18)—C(13)—C(17)—C(20)−55.1(4) C(14)—C(13)—C(17)—C(20) −171.9(3) C(21)—C(20)—C(17)—C(16)−32.0(5) C(22)—C(20)—C(17)—C(16) 97.2(4) C(21)—C(20)—C(17)—C(13) 91.5(5)C(22)—C(20)—C(17)—C(13) −139.3(4) O(1)—C(1)—C(10)—C(5) −174.1(4)C(2)—C(1)—C(10)—C(5) −52.4(5) O(1)—C(1)—C(2)—C(29) −2.0(6)C(10)—C(1)—C(2)—C(29) −122.2(5) O(1)—C(1)—C(2)—C(3) 175.1(4)C(10)—C(1)—C(2)—C(3) 54.9(5) C(18)—C(13)—C(12)—C(11) −64.5(5)C(17)—C(13)—C(12)—C(11) 166.3(3) C(14)—C(13)—C(12)—C(11) 55.7(4)C(12)—C(13)—C(14)—C(8) −59.9(4) C(18)—C(13)—C(14)—C(8) 60.3(5)C(17)—C(13)—C(14)—C(8) 179.4(3) C(12)—C(13)—C(14)—C(15) 167.1(3)C(18)—C(13)—C(14)—C(15) −72.7(4) C(17)—C(13)—C(14)—C(15) 46.3(4)C(24)—C(23)—C(22)—C(30) 63.6(5) C(24)—C(23)—C(22)—C(28) −55.4(5)C(24)—C(23)—C(22)—C(20) −175.9(4) C(21)—C(20)—C(22)—C(30) −164.4(4)C(17)—C(20)—C(22)—C(30) 65.4(4) C(21)—C(20)—C(22)—C(23) 73.9(4)C(17)—C(20)—C(22)—C(23) −56.3(5) C(21)—C(20)—C(22)—C(28) −46.8(5)C(17)—C(20)—C(22)—C(28) −177.0(4) C(1)—C(10)—C(5)—C(6) −124.5(4)C(1)—C(10)—C(5)—C(4) 53.4(5) C(29)—C(2)—C(3)—O(3) −118.5(5)C(1)—C(2)—C(3)—O(3) 64.5(4) C(29)—C(2)—C(3)—C(4) 121.0(5)C(1)—C(2)—C(3)—C(4) −56.1(4) C(8)—C(14)—C(15)—C(16) −159.9(4)C(13)—C(14)—C(15)—C(16) −33.4(4) C(13)—C(17)—C(16)—C(15) 21.6(4)C(20)—C(17)—C(16)—C(15) 151.0(3) C(14)—C(15)—C(16)—C(17) 7.3(5)C(15)—C(14)—C(8)—C(7) 2.0(6) C(13)—C(14)—C(8)—C(7) −120.8(4)C(15)—C(14)—C(8)—C(9) −177.6(4) C(13)—C(14)—C(8)—C(9) 59.6(5)C(11)—C(9)—C(8)—C(7) 125.6(4) C(11)—C(9)—C(8)—C(14) −54.8(5)C(22)—C(23)—C(24)—C(25) −170.1(4) O(25)—C(25)—C(24)—C(23) 59.0(6)C(26)—C(25)—C(24)—C(23) 178.1(6) C(27)—C(25)—C(24)—C(23) −56.4(6)C(8)—C(9)—C(11)—C(12) 51.6(6) C(13)—C(12)—C(11)—C(9) −53.0(5)C(6)—C(5)—C(4)—C(3) 124.7(4) C(10)—C(5)—C(4)—C(3) −53.3(5)O(3)—C(3)—C(4)—C(5) −65.7(5) C(2)—C(3)—C(4)—C(5) 53.8(5)C(10)—C(5)—C(6)—C(7) −1.2(7) C(4)—C(5)—C(6)—C(7) −179.0(4)C(14)—C(8)—C(7)—C(6) 179.4(4) C(9)—C(8)—C(7)—C(6) −1.1(7)C(5)—C(6)—C(7)—C(8) 179.2(4)

TABLE 16 Observed and calculated structure factors for MET-2. h k l 10Fo10Fc 10s h k l 10Fo 10Fc 10s h k l 10Fo 10Fc 10s h k l 10Fo 10Fc 10s h kl 10Fo 10Fc 10s 16 −6 0 23 6 23 8 2 0 224 220 8 −15 −3 1 173 173 6 0 0 1381 388 6 −12 4 1 124 117 4 9 −5 0 179 178 8 10 2 0 276 310 10 −13 −3 1172 175 6 2 0 1 833 936 12 −10 4 1 197 179 4 11 −5 0 59 52 13 12 2 0 175180 7 −11 −3 1 115 118 5 4 0 1 1025 1083 15 −8 4 1 91 99 4 13 −5 0 99 929 14 2 0 56 63 14 −9 −3 1 240 217 8 6 0 1 570 567 9 −6 4 1 295 284 5 15−5 0 0 21 1 18 2 0 194 198 6 −7 −3 1 205 199 8 8 0 1 1171 1214 18 −4 4 1213 211 4 17 −5 0 60 46 13 20 2 0 86 102 12 −5 −3 1 348 327 10 10 0 1 7367 4 −2 4 1 387 390 4 19 −5 0 23 27 23 22 2 0 76 77 13 −3 −3 1 592 56318 12 0 1 331 349 8 0 4 1 224 227 3 4 −4 0 167 167 8 24 2 0 110 145 10−1 −3 1 463 464 10 14 0 1 13 30 13 2 4 1 452 446 5 6 −4 0 204 189 5 26 20 23 38 22 1 −3 1 614 614 12 16 0 1 59 53 7 4 4 1 237 239 4 8 −4 0 11293 8 1 3 0 862 875 14 3 −3 1 295 286 9 18 0 1 215 210 8 6 4 1 54 49 5 10−4 0 72 88 8 3 3 0 361 364 7 5 −3 1 244 265 9 20 0 1 0 10 1 8 4 1 68 555 12 −4 0 183 165 6 7 3 0 457 449 16 7 −3 1 236 224 9 22 0 1 58 50 20 104 1 69 74 5 14 −4 0 196 198 9 9 3 0 222 220 9 9 −3 1 245 235 6 24 0 1 9186 5 12 4 1 97 91 5 16 −4 0 175 189 8 15 3 0 145 135 11 11 −3 1 122 1097 −23 1 1 65 87 16 14 4 1 169 156 9 18 −4 0 40 45 24 17 3 0 220 212 8 13−3 1 157 144 6 −21 1 1 352 352 5 16 4 1 112 138 9 20 −4 0 30 28 30 19 30 126 122 9 15 −3 1 72 59 9 −19 1 1 221 213 3 18 4 1 109 114 9 22 −4 0 022 1 21 3 0 67 69 15 17 −3 1 171 169 9 −17 1 1 202 194 3 20 4 1 32 31 321 −3 0 869 873 18 23 3 0 59 59 16 19 −3 1 52 50 17 −15 1 1 147 143 3 224 1 0 11 1 3 −3 0 364 365 11 25 3 0 0 32 1 21 −3 1 72 59 14 −13 1 1 416412 16 −21 5 1 33 19 33 5 −3 0 400 372 12 0 4 0 429 436 6 23 −3 1 46 4613 −11 1 1 902 941 20 −19 5 1 0 34 1 7 −3 0 476 447 14 2 4 0 403 390 5−26 −2 1 61 57 9 −9 1 1 403 389 6 −17 5 1 92 86 10 9 −3 0 232 220 5 4 40 170 167 5 −24 −2 1 97 102 16 −7 1 1 587 602 9 −15 5 1 143 128 6 11 −30 252 248 6 6 4 0 208 189 4 −22 −2 1 212 217 6 −5 1 1 1112 1157 19 −13 51 157 146 5 13 −3 0 126 117 7 8 4 0 111 93 4 −20 −2 1 199 190 5 −3 1 1965 1044 30 −11 5 1 133 125 5 15 −3 0 138 135 6 10 4 0 77 89 5 −18 −2 147 54 10 −1 1 1 1304 1398 16 −9 5 1 41 24 11 17 −3 0 214 212 6 12 4 0169 165 4 −16 −2 1 214 194 5 1 1 1 1131 1213 15 −7 5 1 110 106 6 19 −3 0110 122 9 14 4 0 190 198 6 −14 −2 1 274 254 5 3 1 1 395 453 5 −5 5 1 309295 6 21 −3 0 71 69 13 16 4 0 184 189 8 −12 −2 1 87 85 6 5 1 1 501 544 7−3 5 1 147 145 3 23 −3 0 41 59 24 18 4 0 52 45 18 −10 −2 1 433 429 14 71 1 556 601 7 −1 5 1 28 32 9 25 −3 0 16 32 16 20 4 0 0 28 1 −8 −2 1 134160 6 9 1 1 322 313 6 1 5 1 90 83 3 0 −2 0 1263 1370 38 22 4 0 41 22 34−6 −2 1 255 251 6 11 1 1 175 185 13 3 5 1 26 29 13 2 −2 0 379 408 10 1 50 130 130 3 −4 −2 1 474 505 10 13 1 1 363 359 8 5 5 1 119 122 5 4 −2 0107 94 4 3 5 0 66 73 4 −2 −2 1 245 257 5 15 1 1 412 413 5 7 5 1 97 91 66 −2 0 224 223 6 5 5 0 35 25 12 0 −2 1 731 763 15 17 1 1 46 47 7 9 5 1110 108 5 8 −2 0 202 222 13 7 5 0 98 95 6 2 −2 1 266 299 5 19 1 1 162160 3 11 5 1 130 133 5 10 −2 0 270 310 22 9 5 0 185 178 4 4 −2 1 303 3185 21 1 1 29 21 14 13 5 1 80 73 7 12 −2 0 175 180 4 11 5 0 11 51 10 6 −21 476 490 11 −26 2 1 48 58 21 15 5 1 113 110 8 14 −2 0 64 62 6 13 5 0111 93 6 8 −2 1 529 557 37 −24 2 1 100 102 10 17 5 1 60 81 10 16 −2 0136 130 10 15 5 0 27 21 27 10 −2 1 459 504 30 −22 2 1 219 218 9 19 5 134 60 21 18 −2 0 192 198 5 17 5 0 28 45 28 12 −2 1 124 130 4 −20 2 1 199190 7 −16 6 1 10 23 10 20 −2 0 112 102 6 19 5 0 22 27 21 14 −2 1 104 896 −18 2 1 63 52 11 −14 6 1 0 20 1 22 −2 0 62 77 17 4 6 0 47 57 11 16 −21 290 278 7 −16 2 1 215 194 6 −12 6 1 61 61 10 24 −2 0 119 145 6 6 6 057 56 6 18 −2 1 393 384 7 −10 2 1 436 431 14 −10 6 1 28 39 24 26 −2 0 038 1 8 6 0 47 52 8 20 −2 1 106 120 21 −8 2 1 134 159 7 −8 6 1 71 79 6 1−1 0 1074 1170 22 10 6 0 22 12 22 22 −2 1 167 142 11 −6 2 1 252 250 9 −66 1 34 39 10 3 −1 0 1769 1951 39 12 6 0 45 37 14 24 −2 1 34 23 20 −2 2 1249 257 4 −4 6 1 25 26 25 5 −1 0 1600 1755 36 14 6 0 0 24 1 26 −2 1 4037 23 0 2 1 730 762 10 4 6 1 36 35 9 7 −1 0 967 1006 20 16 6 0 16 6 16−27 −1 1 0 7 1 2 2 1 259 300 3 6 6 1 89 86 4 9 −1 0 38 38 12 −16 −6 1 2723 26 −25 −1 1 105 98 8 4 2 1 304 317 4 8 6 1 18 31 18 11 −1 0 201 210 5−21 −5 1 0 18 1 −23 −1 1 97 87 9 6 2 1 485 489 15 10 6 1 59 78 8 13 −1 0262 261 6 −19 −5 1 18 35 18 −21 −1 1 349 352 6 8 2 1 556 557 17 12 6 124 10 23 15 −1 0 273 271 4 −17 −5 1 95 86 9 −19 −1 1 221 214 4 10 2 1488 503 15 14 6 1 11 30 10 17 −1 0 232 224 4 −15 −5 1 135 128 8 −17 −1 1204 193 4 12 2 1 134 129 7 −16 −6 2 14 13 14 19 −1 0 311 304 5 −13 −5 1142 146 8 −15 −1 1 141 143 4 14 2 1 103 90 10 −21 −5 2 75 53 10 21 −1 044 41 14 −11 −5 1 131 124 8 −13 −1 1 460 413 9 16 2 1 285 278 10 −19 −52 91 90 9 23 −1 0 87 76 10 −9 −5 1 18 25 17 −11 −1 1 909 940 16 20 2 1108 121 10 −17 −5 2 65 78 12 25 −1 0 46 45 15 9 −5 1 91 108 9 −9 −1 1402 390 10 22 2 1 166 143 9 −15 −5 2 52 57 17 27 −1 0 43 50 13 11 −5 1111 133 8 −7 −1 1 583 602 10 24 2 1 0 23 1 −13 −5 2 12 15 12 2 0 0 312362 4 13 −5 1 54 73 16 −5 −1 1 1075 1157 19 −25 3 1 54 29 18 −11 −5 2117 119 8 4 0 0 117 119 3 15 −5 1 101 110 9 −3 −1 1 951 1044 21 −23 3 133 20 33 −9 −5 2 172 180 7 6 0 0 308 322 5 17 −5 1 83 80 10 −1 −1 1 13221398 27 −21 3 1 61 41 17 9 −5 2 129 118 8 8 0 0 345 323 7 19 −5 1 53 6014 1 −1 1 1140 1212 19 −19 3 1 76 86 13 11 −5 2 50 32 17 10 0 0 10811115 28 −22 −4 1 71 87 11 3 −1 1 404 455 7 −17 3 1 91 102 8 13 −5 2 0 331 12 0 0 621 642 13 −20 −4 1 69 76 12 5 −1 1 507 544 8 −15 3 1 170 17311 15 −5 2 47 32 19 14 0 0 51 44 8 −18 −4 1 42 63 20 7 −1 1 560 600 9−13 3 1 178 175 5 17 −5 2 44 48 19 16 0 0 42 40 9 −16 −4 1 115 100 9 9−1 1 317 313 9 −11 3 1 114 118 4 19 −5 2 56 50 12 18 0 0 50 53 11 −14 −41 69 57 10 11 −1 1 182 183 5 −9 3 1 231 218 6 −24 −4 2 35 14 35 20 0 034 31 19 −12 −4 1 137 117 6 13 −1 1 376 360 8 −7 3 1 194 198 8 −22 −4 20 17 1 22 0 0 92 81 7 −10 −4 1 196 179 6 15 −1 1 417 413 6 −5 3 1 337326 8 −20 −4 2 32 23 31 24 0 0 53 52 8 −8 −4 1 102 99 5 17 −1 1 51 47 7−3 3 1 592 563 9 −18 −4 2 66 74 12 26 0 0 14 7 13 −6 −4 1 289 284 6 19−1 1 164 160 4 −1 3 1 479 464 8 −16 −4 2 41 34 29 1 1 0 1075 1172 16 −4−4 1 202 211 8 21 −1 1 28 21 27 1 3 1 607 614 11 −14 −4 2 46 36 14 3 1 01834 1949 56 4 −4 1 231 239 9 23 −1 1 147 117 8 3 3 1 288 285 5 −12 −4 2104 94 7 5 1 0 1647 1755 25 6 −4 1 45 49 13 25 −1 1 63 65 29 5 3 1 253265 9 −10 −4 2 106 95 10 7 1 0 952 1005 15 8 −4 1 70 55 8 −26 0 1 78 775 7 3 1 236 223 9 −8 −4 2 108 97 5 9 1 0 36 38 4 10 −4 1 77 74 8 −24 0 10 12 1 9 3 1 235 236 6 −6 −4 2 0 26 1 11 1 0 199 210 5 12 −4 1 105 91 7−22 0 1 105 94 20 11 3 1 118 108 6 −4 −4 2 377 362 13 13 1 0 238 260 914 −4 1 174 156 7 −20 0 1 190 175 5 13 3 1 145 144 8 4 −4 2 102 107 8 151 0 271 271 4 16 −4 1 144 138 8 −18 0 1 383 366 8 17 3 1 179 169 8 6 −42 131 103 5 17 1 0 233 224 4 18 −4 1 110 114 9 −16 0 1 54 57 6 19 3 1 4950 22 8 −4 2 61 56 11 19 1 0 309 304 4 20 −4 1 28 31 27 −14 0 1 770 74417 21 3 1 69 59 15 10 −4 2 251 255 6 21 1 0 41 40 9 22 −4 1 23 11 23 −120 1 19 32 19 23 3 1 74 46 13 12 −4 2 140 125 7 23 1 0 55 76 19 −25 −3 10 29 1 −10 0 1 575 593 17 −22 4 1 61 88 16 14 −4 2 27 33 27 0 2 0 12831369 22 −23 −3 1 26 19 26 −8 0 1 543 599 9 −20 4 1 66 75 14 16 −4 2 4213 25 2 2 0 371 406 6 −21 −3 1 43 42 27 −6 0 1 2059 2218 45 −18 4 1 4764 21 18 −4 2 114 132 8 4 2 0 102 94 6 −19 −3 1 100 87 10 −4 0 1 15381686 33 −16 4 1 112 100 10 20 −4 2 38 58 32 6 2 0 233 223 8 −17 −3 1 104102 7 −2 0 1 417 443 8 −14 4 1 59 56 8 22 −4 2 20 19 19 −25 −3 2 0 15 1−8 0 2 909 967 21 21 3 2 55 56 18 18 −4 3 74 77 12 −14 0 3 214 230 4 −23−3 2 48 24 20 −6 0 2 2200 2323 38 23 3 2 34 45 33 20 −4 3 38 25 30 −12 03 313 309 6 −21 −3 2 86 93 11 −4 0 2 598 601 9 −24 4 2 41 14 31 −25 −3 361 63 9 −10 0 3 360 335 5 −19 −3 2 103 110 10 −2 0 2 670 726 10 −22 4 20 17 1 −23 −3 3 0 35 1 −8 0 3 1125 1138 19 −17 −3 2 153 146 7 0 0 2 12791357 22 −20 4 2 12 22 12 −21 −3 3 58 53 15 −6 0 3 1022 1054 15 −15 −3 290 80 7 2 0 2 585 617 9 −18 4 2 74 74 13 −19 −3 3 121 114 9 −4 0 3 227229 3 −13 −3 2 162 158 5 4 0 2 1340 1409 20 −16 4 2 7 34 6 −17 −3 3 161151 6 −2 0 3 1111 1236 17 −11 −3 2 334 343 8 6 0 2 1056 1084 16 −14 4 233 36 17 −15 −3 3 86 82 7 0 0 3 744 848 11 −9 −3 2 201 191 8 8 0 2 23 3112 −12 4 2 97 94 5 −13 −3 3 237 228 8 2 0 3 1244 1255 19 −7 −3 2 764 74023 10 0 2 71 61 5 −10 4 2 103 95 4 −11 −3 3 372 350 8 4 0 3 222 277 4 −5−3 2 714 680 21 12 0 2 520 511 17 −8 4 2 103 96 4 −9 −3 3 362 315 12 6 03 9 2 9 −3 −3 2 541 545 16 14 0 2 357 365 6 −6 4 2 21 26 21 −7 −3 3 340301 10 8 0 3 318 290 6 −1 −3 2 523 549 11 16 0 2 302 295 5 −4 4 2 396362 7 −5 −3 3 219 236 8 10 0 3 872 844 15 1 −3 2 179 169 4 18 0 2 68 5717 −2 4 2 234 231 2 −3 −3 3 314 326 10 12 0 3 65 71 6 3 −3 2 384 372 1220 0 2 168 173 6 0 4 2 161 158 2 −1 −3 3 474 491 10 14 0 3 168 161 3 5−3 2 543 516 16 22 0 2 53 44 11 2 4 2 397 387 4 1 −3 3 248 236 6 16 0 348 11 8 7 −3 2 195 188 8 24 0 2 16 38 16 12 4 2 133 125 5 3 −3 3 46 5215 18 0 3 169 177 6 9 −3 2 108 87 8 −23 1 2 123 155 9 14 4 2 28 33 27 5−3 3 100 106 8 20 0 3 221 221 6 11 −3 2 224 226 6 −21 1 2 188 174 3 16 42 33 13 33 7 −3 3 217 212 8 22 0 3 36 17 31 13 −3 2 226 210 6 −19 1 2 019 1 18 4 2 138 132 8 9 −3 3 76 67 7 24 0 3 25 18 24 15 −3 2 175 163 7−17 1 2 104 86 4 20 4 2 36 58 36 11 −3 3 294 298 7 −23 1 3 63 63 6 17 −32 128 115 9 −15 1 2 76 74 6 22 4 2 0 19 1 13 −3 3 120 114 8 −21 1 3 8078 4 19 −3 2 101 124 10 −13 1 2 352 405 16 −21 5 2 62 53 14 15 −3 3 193170 7 −19 1 3 50 44 5 21 −3 2 68 56 13 −11 1 2 792 818 18 −19 5 2 68 9026 17 −3 3 171 195 8 −17 1 3 71 67 3 23 −3 2 0 45 1 −9 1 2 323 318 6 −175 2 68 78 10 19 −3 3 76 77 12 −15 1 3 217 211 4 −26 −2 2 35 60 28 −7 1 2290 295 4 −15 5 2 58 57 10 21 −3 3 115 109 8 −13 1 3 307 277 7 −24 −2 290 122 17 −5 1 2 682 732 10 −13 5 2 0 15 1 23 −3 3 20 22 20 −11 1 3 395389 6 −22 −2 2 111 113 16 −3 1 2 685 708 9 −11 5 2 127 118 11 −28 −2 358 55 14 −9 1 3 190 197 3 −20 −2 2 62 31 9 −1 1 2 210 235 3 −9 5 2 183181 6 −26 −2 3 69 81 8 −7 1 3 514 543 7 −18 −2 2 131 131 6 1 1 2 806 84711 −7 5 2 184 179 4 −24 −2 3 69 79 15 −5 1 3 649 696 9 −16 −2 2 110 1155 3 1 2 743 795 10 −5 5 2 148 138 4 −22 −2 3 118 94 8 −3 1 3 1714 179923 −14 −2 2 240 231 5 5 1 2 483 506 6 −3 5 2 36 37 8 −20 −2 3 92 70 5 −11 3 829 881 14 −12 −2 2 406 382 9 7 1 2 514 546 7 −1 5 2 107 103 3 −18−2 3 127 115 5 1 1 3 235 237 3 −10 −2 2 337 359 10 9 1 2 149 155 4 1 5 2113 118 3 −16 −2 3 179 174 5 3 1 3 94 86 2 −8 −2 2 281 276 13 11 1 2 362383 14 3 5 2 74 75 5 −14 −2 3 138 124 8 5 1 3 248 228 3 −6 −2 2 363 3438 13 1 2 270 290 5 5 5 2 110 102 4 −12 −2 3 102 96 6 7 1 3 129 129 4 −4−2 2 155 160 3 15 1 2 173 162 3 7 5 2 26 51 26 −10 −2 3 793 938 23 9 1 3318 343 8 −2 −2 2 350 360 7 17 1 2 262 253 4 9 5 2 139 118 5 −8 −2 3 395397 28 11 1 3 117 105 4 0 −2 2 328 334 7 19 1 2 391 384 6 11 5 2 10 3210 −6 −2 3 152 167 5 13 1 3 224 221 4 2 −2 2 403 425 7 21 1 2 50 46 9 135 2 0 32 1 −4 −2 3 181 173 4 15 1 3 287 269 4 4 −2 2 235 216 4 −26 2 249 60 21 15 5 2 40 32 16 −2 −2 3 452 478 9 17 1 3 62 56 6 6 −2 2 329 3346 −24 2 2 102 122 10 17 5 2 44 48 25 0 −2 3 283 274 6 19 1 3 94 97 5 8−2 2 252 273 18 −22 2 2 114 114 10 19 5 2 36 50 35 2 −2 3 410 412 15 211 3 104 107 4 10 −2 2 258 257 7 −20 2 2 50 32 17 −16 6 2 2 13 1 4 −2 3179 185 4 −26 2 3 81 81 12 12 −2 2 344 339 6 −18 2 2 125 131 6 −14 6 238 36 19 6 −2 3 41 45 6 −24 2 3 61 79 17 14 −2 2 180 174 6 −16 2 2 110115 6 −12 6 2 33 28 32 8 −2 3 394 395 24 −22 2 3 112 95 10 16 −2 2 112102 7 −14 2 2 236 231 6 −10 6 2 0 21 1 10 −2 3 170 167 4 −20 2 3 87 7116 18 −2 2 146 142 13 −12 2 2 396 381 9 −8 6 2 0 35 1 12 −2 3 223 212 6−18 2 3 126 115 7 20 −2 2 131 147 14 −10 2 2 311 361 19 −6 6 2 17 41 1714 −2 3 50 42 13 −16 2 3 182 174 5 22 −2 2 48 43 12 −8 2 2 281 274 16 −46 2 15 19 15 16 −2 3 126 142 7 −14 2 3 137 124 12 24 −2 2 40 38 17 −6 22 369 342 8 4 6 2 43 48 6 18 −2 3 140 136 10 −12 2 3 99 96 9 −27 −1 2 5764 23 −4 2 2 167 160 4 6 6 2 50 51 7 20 −2 3 140 155 12 −10 2 3 767 93824 −25 −1 2 83 70 10 −2 2 2 347 358 4 8 6 2 38 29 11 22 −2 3 32 51 32 −82 3 402 398 22 −23 −1 2 120 155 5 0 2 2 321 335 4 10 6 2 20 20 20 24 −23 50 47 11 −6 2 3 153 167 6 −21 −1 2 192 174 5 2 2 2 413 426 5 12 6 2 018 1 −27 −1 3 130 110 6 −4 2 3 183 171 3 −19 −1 2 0 18 1 4 2 2 233 215 314 6 2 48 38 12 −25 −1 3 27 15 26 −2 2 3 441 477 5 −17 −1 2 97 87 4 6 22 327 334 5 −16 −6 3 45 20 15 −23 −1 3 38 63 16 0 2 3 273 276 3 −15 −1 265 74 5 8 2 2 271 272 7 −21 −5 3 52 18 13 −21 −1 3 73 78 6 2 2 3 406 4135 −13 −1 2 370 405 6 10 2 2 259 257 5 −19 −5 3 45 44 18 −19 −1 3 36 4411 4 2 3 172 185 3 −11 −1 2 813 818 14 12 2 2 346 340 4 −17 −5 3 0 30 1−17 −1 3 72 66 4 6 2 3 40 45 5 −9 −1 2 325 320 6 14 2 2 178 174 3 −15 −53 33 58 32 −15 −1 3 217 211 6 8 2 3 394 394 9 −7 −1 2 288 296 5 16 2 293 102 11 −13 −5 3 122 154 8 −13 −1 3 323 277 6 10 2 3 172 166 4 −5 −1 2685 732 12 20 2 2 126 147 9 −11 −5 3 102 105 8 −11 −1 3 412 390 8 12 2 3223 211 3 −3 −1 2 654 708 12 22 2 2 15 42 14 −9 −5 3 20 16 20 −9 −1 3186 196 4 14 2 3 51 42 4 −1 −1 2 205 233 4 24 2 2 6 38 6 9 −5 3 157 1568 −7 −1 3 530 541 9 16 2 3 127 142 9 1 −1 2 815 849 15 −25 3 2 22 15 2211 −5 3 66 56 13 −5 −1 3 661 696 11 20 2 3 127 155 9 3 −1 2 759 794 13−23 3 2 27 24 26 13 −5 3 148 141 8 −3 −1 3 1674 1797 32 22 2 3 47 51 205 −1 2 492 505 8 −21 3 2 90 93 12 15 −5 3 50 53 16 −1 −1 3 809 881 14 242 3 33 47 33 7 −1 2 522 546 14 −19 3 2 96 109 11 17 −5 3 44 50 19 1 −1 3231 236 4 −25 3 3 38 63 38 9 −1 2 162 156 4 −17 3 2 143 147 12 −24 −4 333 12 33 3 −1 3 93 86 4 −23 3 3 32 35 32 11 −1 2 381 386 6 −15 3 2 84 8013 −22 −4 3 54 32 16 5 −1 3 244 228 5 −21 3 3 45 53 29 13 −1 2 274 291 6−13 3 2 159 158 6 −20 −4 3 0 28 1 7 −1 3 130 129 5 −19 3 3 103 113 11 15−1 2 172 162 4 −11 3 2 326 343 6 −18 −4 3 60 46 13 9 −1 3 338 343 6 −173 3 161 152 6 17 −1 2 270 253 4 −9 3 2 197 189 6 −16 −4 3 64 78 13 11 −13 125 105 4 −15 3 3 76 82 7 19 −1 2 388 384 6 −7 3 2 768 740 17 −14 −4 30 21 1 13 −1 3 219 221 4 −13 3 3 224 227 5 21 −1 2 23 45 22 −5 3 2 706681 15 −12 −4 3 104 106 6 15 −1 3 284 270 5 −11 3 3 360 350 7 23 −1 2 8776 10 −3 3 2 545 546 9 −10 −4 3 175 167 5 17 −1 3 55 57 8 −9 3 3 366 3168 25 −1 2 17 14 16 −1 3 2 519 550 17 −8 −4 3 148 135 5 19 −1 3 95 97 9−7 3 3 330 302 8 −26 0 2 43 34 9 1 3 2 166 172 4 −6 −4 3 121 119 5 21 −13 106 107 11 −5 3 3 220 237 6 −24 0 2 135 129 6 3 3 2 384 371 7 −4 −4 3164 143 7 23 −1 3 69 65 12 −3 3 3 324 326 6 −22 0 2 41 49 41 5 3 2 521517 18 4 −4 3 272 273 6 25 −1 3 57 43 10 −1 3 3 481 492 14 −20 0 2 76 625 7 3 2 185 188 9 6 −4 3 61 56 20 −26 0 3 35 27 35 1 3 3 234 237 5 −18 02 115 91 6 9 3 2 106 87 7 8 −4 3 156 171 6 −24 0 3 47 44 12 3 3 3 46 534 −16 0 2 174 176 3 11 3 2 224 226 6 10 −4 3 35 31 25 −22 0 3 0 6 1 5 33 102 106 4 −14 0 2 213 236 4 13 3 2 228 210 8 12 −4 3 158 156 13 −20 03 15 9 14 7 3 3 218 211 8 −12 0 2 266 266 5 17 3 2 122 115 10 14 −4 3202 205 8 −18 0 3 87 83 4 9 3 3 77 68 6 −10 0 2 881 931 13 19 3 2 96 12410 16 −4 3 189 196 8 −16 0 3 138 114 3 11 3 3 307 298 9 13 3 3 114 11410 14 −4 4 93 77 11 −16 0 4 117 118 5 9 3 4 99 99 7 −27 −3 5 86 76 6 153 3 201 169 9 16 −4 4 15 35 14 −14 0 4 261 256 5 11 3 4 102 107 10 −25−3 5 88 76 7 19 3 3 81 77 12 18 −4 4 54 51 16 −12 0 4 547 540 9 13 3 4108 96 10 −23 −3 5 0 23 1 21 3 3 80 109 12 20 −4 4 18 35 18 −10 0 4 2415 13 15 3 4 227 228 9 −21 −3 5 30 18 30 23 3 3 35 22 35 −27 −3 4 48 3911 −8 0 4 834 878 15 19 3 4 26 4 25 −19 −3 5 70 65 20 −24 4 3 0 12 1 −25−3 4 20 23 19 −6 0 4 80 82 3 21 3 4 50 55 19 −17 −3 5 92 80 13 −22 4 331 32 31 −23 −3 4 17 31 17 −4 0 4 1279 1392 23 −24 4 4 0 32 1 −15 −3 569 72 8 −20 4 3 35 28 35 −21 −3 4 178 154 8 −2 0 4 315 357 5 −22 4 4 6135 17 −13 −3 5 255 231 6 −18 4 3 56 46 18 −19 −3 4 12 2 11 0 0 4 11161209 17 −20 4 4 45 35 24 −11 −3 5 349 338 7 −16 4 3 57 78 17 −17 −3 4 7077 14 2 0 4 444 445 7 −18 4 4 87 85 11 −9 −3 5 360 349 7 −14 4 3 0 21 1−15 −3 4 139 130 5 4 0 4 135 130 3 −16 4 4 168 153 9 −7 −3 5 244 225 8−12 4 3 101 105 5 −13 −3 4 99 104 6 6 0 4 185 185 3 −14 4 4 191 198 5 −5−3 5 160 143 7 −10 4 3 173 168 4 −11 −3 4 284 269 6 8 0 4 770 754 13 −124 4 81 86 5 −3 −3 5 262 276 6 −8 4 3 140 135 4 −9 −3 4 146 162 8 10 0 4564 516 10 −10 4 4 0 22 1 −1 −3 5 21 26 20 −6 4 3 130 119 4 −7 −3 4 237264 9 12 0 4 199 188 3 −8 4 4 175 179 3 1 −3 5 268 280 8 −4 4 3 162 1445 −5 −3 4 118 125 7 14 0 4 179 164 3 −6 4 4 18 22 18 3 −3 5 163 170 8 −24 3 164 155 2 −3 −3 4 114 105 5 16 0 4 0 9 1 −4 4 4 154 151 3 5 −3 5 105108 6 0 4 3 80 77 2 −1 −3 4 95 83 9 18 0 4 162 146 6 −2 4 4 289 281 4 7−3 5 89 90 14 2 4 3 208 195 3 1 −3 4 77 76 5 20 0 4 0 12 1 0 4 4 274 2633 9 −3 5 268 270 7 4 4 3 282 272 6 3 −3 4 330 311 10 22 0 4 92 84 14 2 44 125 129 2 11 −3 5 258 248 7 6 4 3 73 56 6 5 −3 4 97 101 9 24 0 4 22 3421 4 4 4 162 153 4 13 −3 5 187 182 15 8 4 3 158 172 4 7 −3 4 229 227 6−23 1 4 0 27 1 6 4 4 80 70 6 15 −3 5 94 111 10 10 4 3 51 31 11 9 −3 4107 98 6 −21 1 4 197 192 3 8 4 4 133 137 8 17 −3 5 23 34 22 14 4 3 199206 8 11 −3 4 111 107 7 −19 1 4 114 104 3 10 4 4 276 267 5 19 −3 5 127103 8 16 4 3 189 196 8 13 −3 4 112 96 7 −17 1 4 131 119 3 16 4 4 21 3520 21 −3 5 53 43 15 18 4 3 70 76 13 15 −3 4 241 228 8 −15 1 4 67 65 4 184 4 72 51 12 −28 −2 5 0 17 1 20 4 3 25 26 24 17 −3 4 135 128 9 −13 1 4189 198 5 20 4 4 60 35 14 −26 −2 5 0 10 1 −21 5 3 4 18 4 19 −3 4 0 3 1−11 1 4 327 317 5 −21 5 4 33 25 32 −24 −2 5 77 111 7 −19 5 3 51 44 12 21−3 4 57 55 14 −9 1 4 977 1049 13 −19 5 4 33 44 32 −22 −2 5 64 55 9 −17 53 36 30 36 −28 −2 4 85 98 9 −7 1 4 166 184 3 −17 5 4 93 122 18 −20 −2 5107 100 7 −15 5 3 57 58 10 −26 −2 4 55 65 10 −5 1 4 477 502 6 −15 5 4 6575 9 −18 −2 5 147 125 7 −13 5 3 144 154 18 −24 −2 4 77 91 7 −3 1 4 266278 4 −13 5 4 31 42 30 −16 −2 5 89 89 6 −11 5 3 118 105 10 −22 −2 4 130133 12 −1 1 4 991 1024 23 −11 5 4 160 169 5 −14 −2 5 325 326 6 −9 5 3 3416 20 −20 −2 4 108 93 7 1 1 4 413 429 6 −9 5 4 117 103 6 −12 −2 5 75 826 −7 5 3 135 135 5 −18 −2 4 162 147 4 3 1 4 28 30 6 −7 5 4 342 333 8 −10−2 5 328 327 12 −5 5 3 19 14 19 −16 −2 4 130 116 13 5 1 4 372 385 5 −5 54 198 205 5 −8 −2 5 554 568 18 −3 5 3 385 387 6 −14 −2 4 326 327 6 7 1 4191 195 4 −3 5 4 187 183 3 −6 −2 5 424 432 7 −1 5 3 156 149 2 −12 −2 4549 586 17 9 1 4 139 157 5 −1 5 4 28 44 5 −4 −2 5 201 208 4 1 5 3 106105 3 −10 −2 4 84 114 16 11 1 4 342 332 4 1 5 4 36 37 8 −2 −2 5 373 3768 3 5 3 62 54 6 −8 −2 4 215 240 21 13 1 4 229 203 4 3 5 4 144 129 4 0 −25 443 432 9 5 5 3 44 38 10 −6 −2 4 237 241 4 15 1 4 261 249 4 5 5 4 9599 6 2 −2 5 369 382 8 7 5 3 140 131 5 −4 −2 4 153 148 3 17 1 4 70 53 5 75 4 255 244 8 4 −2 5 253 257 6 9 5 3 157 156 5 −2 −2 4 189 193 5 19 1 488 83 6 9 5 4 58 62 9 6 −2 5 213 203 12 11 5 3 51 55 11 0 −2 4 484 49610 21 1 4 29 27 13 11 5 4 103 94 6 8 −2 5 270 272 9 13 5 3 145 141 5 2−2 4 513 527 9 −26 2 4 64 65 16 13 5 4 53 46 10 10 −2 5 86 76 7 15 5 354 53 12 4 −2 4 413 435 7 −24 2 4 85 91 12 15 5 4 26 23 25 12 −2 5 29 2729 17 5 3 49 50 14 6 −2 4 267 255 6 −22 2 4 126 133 10 17 5 4 0 19 1 14−2 5 79 83 9 −16 6 3 0 20 1 8 −2 4 172 159 9 −20 2 4 103 93 8 −16 6 4 208 20 16 −2 5 25 15 24 −14 6 3 31 25 31 10 −2 4 178 182 5 −18 2 4 161 1486 −14 6 4 0 15 1 18 −2 5 163 142 8 −12 6 3 0 11 1 12 −2 4 309 321 7 −162 4 128 116 5 −12 6 4 73 60 15 20 −2 5 56 50 29 −10 6 3 32 31 17 14 −2 4106 113 13 −14 2 4 315 327 7 −10 6 4 132 133 5 22 −2 5 0 9 1 −8 6 3 4144 9 16 −2 4 68 70 20 −12 2 4 567 585 36 −8 6 4 76 71 5 −29 −1 5 50 50 8−6 6 3 128 137 5 18 −2 4 2 25 2 −10 2 4 84 116 15 −6 6 4 130 130 7 −27−1 5 74 83 8 4 6 3 113 116 3 20 −2 4 56 59 11 −8 2 4 226 241 8 4 6 4 7175 4 −25 −1 5 87 70 10 6 6 3 64 57 5 22 −2 4 46 64 21 −6 2 4 240 241 3 66 4 86 85 4 −23 −1 5 45 63 44 8 6 3 48 53 10 −29 −1 4 71 74 5 −4 2 4 150149 2 8 6 4 0 28 1 −21 −1 5 69 77 6 10 6 3 29 38 23 −27 −1 4 34 38 34 −22 4 187 194 3 10 6 4 17 30 17 −19 −1 5 163 159 4 12 6 3 0 5 1 −25 −1 425 28 24 0 2 4 479 497 6 12 6 4 33 61 22 −17 −1 5 180 172 3 14 6 3 33 4620 −23 −1 4 29 27 28 2 2 4 522 527 8 −21 −5 5 38 51 23 −15 −1 5 35 26 14−16 −6 4 0 8 1 −21 −1 4 195 193 4 4 2 4 420 436 6 −19 −5 5 56 72 13 −13−1 5 311 262 6 −21 −5 4 5 25 4 −19 −1 4 126 104 4 6 2 4 265 255 7 −17 −55 78 76 11 −11 −1 5 411 422 7 −19 −5 4 24 44 23 −17 −1 4 130 119 3 8 2 4164 158 4 −15 −5 5 144 127 8 −9 −1 5 300 317 5 −17 −5 4 122 122 8 −15 −14 59 65 8 10 2 4 176 183 3 −13 −5 5 81 78 10 −7 −1 5 442 458 8 −15 −5 468 75 11 −13 −1 4 194 198 4 12 2 4 316 321 4 −11 −5 5 199 193 8 −5 −1 5539 543 9 −13 −5 4 50 42 17 −11 −1 4 328 315 6 14 2 4 119 112 3 7 −5 583 99 10 −3 −1 5 393 406 6 −11 −5 4 171 169 7 −9 −1 4 1002 1049 17 16 24 67 71 6 9 −5 5 50 46 17 −1 −1 5 451 460 7 9 −5 4 74 62 11 −7 −1 4 174185 5 18 2 4 0 25 1 11 −5 5 0 35 1 1 −1 5 188 199 3 11 −5 4 98 93 9 −5−1 4 484 501 8 20 2 4 47 59 23 13 −5 5 0 14 1 3 −1 5 280 296 8 13 −5 4 046 1 −3 −1 4 268 279 5 22 2 4 48 64 19 15 −5 5 31 55 31 5 −1 5 218 23310 15 −5 4 23 23 23 −1 −1 4 958 1024 15 −27 3 4 44 39 22 −24 −4 5 48 6117 7 −1 5 264 257 11 17 −5 4 11 19 11 1 −1 4 393 426 7 −25 3 4 42 23 39−22 −4 5 103 87 9 9 −1 5 637 624 10 −24 −4 4 46 32 18 3 −1 4 20 27 19−23 3 4 37 31 36 −20 −4 5 91 113 9 11 −1 5 206 201 4 −22 −4 4 45 35 20 5−1 4 395 387 8 −21 3 4 161 155 9 −18 −4 5 25 30 24 13 −1 5 156 142 4 −20−4 4 0 36 1 7 −1 4 188 195 4 −19 3 4 0 3 1 −16 −4 5 69 41 12 15 −1 5 115110 5 −18 −4 4 70 86 11 9 −1 4 141 156 4 −17 3 4 72 77 16 −14 −4 5 80 638 17 −1 5 52 55 10 −16 −4 4 156 153 8 11 −1 4 335 333 5 −15 3 4 141 1306 −12 −4 5 224 209 6 19 −1 5 163 161 8 −14 −4 4 205 198 6 13 −1 4 221205 4 −13 3 4 92 103 5 −10 −4 5 282 270 6 21 −1 5 0 9 1 −12 −4 4 94 86 715 −1 4 258 249 5 −11 3 4 274 269 5 −8 −4 5 205 205 5 23 −1 5 0 18 1 −10−4 4 23 22 23 17 −1 4 50 52 10 −9 3 4 166 162 5 −6 −4 5 61 57 18 −26 0 567 70 8 −8 −4 4 167 179 5 19 −1 4 92 83 7 −7 3 4 246 263 6 4 −4 5 69 748 −24 0 5 117 132 6 −6 −4 4 44 22 10 21 −1 4 0 27 1 −5 3 4 119 125 3 6−4 5 265 270 6 −22 0 5 17 41 17 −4 −4 4 143 151 7 23 −1 4 79 61 10 −3 34 110 105 3 8 −4 5 327 322 10 −20 0 5 43 46 11 4 −4 4 157 154 5 −26 0 40 13 1 −1 3 4 82 84 6 10 −4 5 294 307 7 −18 0 5 103 112 4 6 −4 4 76 70 7−24 0 4 118 108 11 1 3 4 77 77 3 12 −4 5 82 68 12 −16 0 5 158 157 3 8 −44 138 138 6 −22 0 4 49 47 10 3 3 4 327 311 6 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6 5 84 79 4 −23 −1 6 112 115 6 8 2 6 264 259 4 13 −5 7 0 331 −10 2 5 342 327 6 4 6 5 29 31 11 −21 −1 6 52 62 7 10 2 6 184 173 3 −24−4 7 51 35 15 −8 2 5 564 567 13 6 6 5 84 88 4 −19 −1 6 65 69 5 12 2 6 7675 4 −22 −4 7 0 26 1 −6 2 5 431 432 6 8 6 5 31 25 30 −17 −1 6 41 23 8 142 6 59 58 5 −20 −4 7 140 138 8 −4 2 5 200 207 3 10 6 5 58 64 10 −15 −1 6178 177 4 16 2 6 14 14 13 −18 −4 7 144 128 8 −2 2 5 379 376 6 12 6 5 3448 18 −13 −1 6 64 72 5 18 2 6 78 91 14 −16 −4 7 53 54 16 0 2 5 450 433 9−21 −5 6 28 40 28 −11 −1 6 266 283 5 20 2 6 60 62 14 −14 −4 7 74 87 8 22 5 380 381 8 −19 −5 6 58 81 13 −9 −1 6 807 851 59 22 2 6 46 63 17 −12−4 7 41 46 15 4 2 5 261 258 5 −17 −5 6 52 25 15 −7 −1 6 497 517 19 −27 36 54 15 17 −10 −4 7 14 20 13 6 2 5 210 203 4 −15 −5 6 63 69 13 −5 −1 6508 526 8 −25 3 6 52 43 22 −8 −4 7 307 323 7 8 2 5 280 272 3 −13 −5 6148 146 8 −3 −1 6 794 821 12 −23 3 6 95 104 12 −6 −4 7 240 240 6 10 2 591 76 3 7 −5 6 68 67 12 −1 −1 6 662 670 10 −21 3 6 106 126 10 2 −4 7 199192 8 12 2 5 25 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5 272 270 12 −23 −3 6 93 104 9 0 0 6 248265 4 −14 4 6 154 165 9 7 −3 7 260 243 7 11 3 5 259 248 9 −21 −3 6 121125 9 2 0 6 63 56 4 −12 4 6 168 156 5 9 −3 7 188 183 6 13 3 5 204 182 8−19 −3 6 65 60 17 4 0 6 110 110 6 −10 4 6 142 137 4 11 −3 7 145 145 2315 3 5 81 111 13 −17 −3 6 121 113 10 6 0 6 0 18 1 −8 4 6 168 177 4 13 −37 118 135 9 19 3 5 88 103 11 −15 −3 6 76 69 9 8 0 6 664 610 12 −6 4 6170 156 4 15 −3 7 50 46 19 17 −3 7 123 94 9 −7 1 7 447 467 9 −11 5 7 161153 5 6 −2 8 53 56 10 −14 2 8 208 200 3 19 −3 7 57 59 13 −5 1 7 433 4739 −9 5 7 79 85 10 8 −2 8 140 123 6 −12 2 8 172 160 3 −28 −2 7 55 68 18−3 1 7 151 169 3 −7 5 7 48 61 12 10 −2 8 88 79 8 −10 2 8 279 284 4 −26−2 7 65 59 8 −1 1 7 652 668 10 −5 5 7 156 162 5 12 −2 8 188 159 9 −8 2 8400 403 8 −24 −2 7 137 146 5 1 1 7 340 341 7 −3 5 7 191 183 3 14 −2 8165 153 8 −6 2 8 238 220 4 −22 −2 7 37 29 16 3 1 7 322 323 8 −1 5 7 156148 2 16 −2 8 81 73 8 −4 2 8 162 166 4 −20 −2 7 117 109 7 5 1 7 251 2505 1 5 7 43 29 42 18 −2 8 0 14 1 −2 2 8 347 323 5 −18 −2 7 143 142 6 7 17 449 431 6 9 5 7 75 77 7 20 −2 8 36 36 15 0 2 8 118 111 4 −16 −2 7 4 374 9 1 7 363 359 5 11 5 7 54 56 12 −29 −1 8 55 48 9 2 2 8 220 212 3 −14−2 7 218 201 5 11 1 7 161 155 4 13 5 7 0 33 1 −27 −1 8 39 40 17 4 2 8159 144 3 −12 −2 7 313 294 6 13 1 7 15 28 15 −16 6 7 40 25 19 −25 −1 874 75 10 6 2 8 52 57 6 −10 −2 7 207 228 8 15 1 7 100 88 10 −14 6 7 45 6015 −23 −1 8 111 127 9 8 2 8 135 123 4 −8 −2 7 181 170 5 17 1 7 78 75 5−12 6 7 64 70 12 −21 −1 8 121 109 5 10 2 8 91 79 4 −6 −2 7 207 214 5 191 7 45 46 7 −10 6 7 64 75 7 −19 −1 8 85 94 4 12 2 8 175 159 5 −4 −2 7159 173 5 −28 2 7 49 68 21 −8 6 7 25 28 24 −17 −1 8 245 242 5 14 2 8 159153 4 −2 −2 7 217 213 5 −26 2 7 74 59 14 −6 6 7 33 33 9 −15 −1 8 97 92 416 2 8 56 73 21 0 −2 7 94 94 5 −24 2 7 150 146 9 4 6 7 72 75 4 −13 −1 8282 287 5 18 2 8 0 15 1 2 −2 7 161 149 8 −22 2 7 58 29 18 6 6 7 32 39 11−11 −1 8 127 137 7 20 2 8 17 36 17 4 −2 7 171 178 4 −20 2 7 119 110 7 86 7 40 45 14 −9 −1 8 758 744 16 −27 3 8 85 69 12 6 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115 3−21 −1 7 50 48 7 6 2 7 132 130 3 −20 −4 8 74 90 10 17 −1 8 109 104 6 −13 8 124 108 2 −19 −1 7 243 229 4 8 2 7 280 253 4 −18 −4 8 58 61 14 19 −18 40 52 16 1 3 8 41 38 6 −17 −1 7 83 83 4 10 2 7 82 71 4 −16 −4 8 152125 8 −28 0 8 0 12 1 3 3 8 109 105 3 −15 −1 7 96 98 4 12 2 7 62 61 6 −14−4 8 71 68 11 −26 0 8 67 64 7 5 3 8 171 172 2 −13 −1 7 123 135 4 14 2 7147 122 4 −12 −4 8 97 92 7 −24 0 8 110 124 6 7 3 8 116 112 3 −11 −1 7154 161 4 16 2 7 85 88 14 −10 −4 8 225 219 6 −22 0 8 15 14 15 9 3 8 4646 6 −9 −1 7 207 214 9 18 2 7 93 116 12 −8 −4 8 220 223 6 −20 0 8 261264 6 11 3 8 133 140 10 −7 −1 7 474 467 9 20 2 7 0 19 1 −6 −4 8 76 71 9−18 0 8 129 135 7 13 3 8 55 63 18 −5 −1 7 438 473 11 −27 3 7 100 92 10 2−4 8 136 132 8 −16 0 8 30 25 9 15 3 8 67 89 16 −3 −1 7 162 170 3 −25 3 7132 115 9 4 −4 8 141 129 6 −14 0 8 117 95 4 −24 4 8 0 31 1 −1 −1 7 648666 10 −23 3 7 84 78 12 6 −4 8 114 116 7 −12 0 8 444 426 8 −22 4 8 98 8711 1 −1 7 338 339 8 −21 3 7 62 69 16 8 −4 8 205 199 8 −10 0 8 42 55 8−20 4 8 79 90 12 3 −1 7 325 324 10 −19 3 7 46 59 46 10 −4 8 53 46 19 −80 8 321 317 6 −18 4 8 33 60 32 5 −1 7 253 250 5 −17 3 7 251 223 7 12 −48 123 105 9 −6 0 8 330 316 5 −16 4 8 153 125 9 7 −1 7 446 432 7 −15 3 7113 119 6 14 −4 8 24 25 24 −4 0 8 545 598 12 −14 4 8 67 68 8 9 −1 7 357359 5 −13 3 7 80 88 7 16 −4 8 73 50 10 −2 0 8 7 6 6 −12 4 8 101 91 5 11−1 7 167 153 6 −11 3 7 108 110 4 −27 −3 8 79 68 6 0 0 8 145 144 8 −10 48 220 219 4 13 −1 7 33 27 17 −9 3 7 89 91 2 −25 −3 8 98 82 6 2 0 8 426432 11 −8 4 8 231 223 4 15 −1 7 78 88 8 −7 3 7 94 89 2 −23 −3 8 7 21 7 40 8 193 194 4 −6 4 8 70 70 3 17 −1 7 64 75 10 −5 3 7 182 170 3 −21 −3 873 95 11 6 0 8 224 200 3 −4 4 8 136 130 3 19 −1 7 39 46 17 −3 3 7 204205 3 −19 −3 8 27 13 26 8 0 8 48 58 6 −2 4 8 126 114 4 21 −1 7 0 25 1 −13 7 130 115 2 −17 −3 8 111 100 6 10 0 8 23 7 22 0 4 8 83 83 3 −28 0 7 012 1 1 3 7 88 82 3 −15 −3 8 0 24 1 12 0 8 125 125 5 2 4 8 139 133 3 −260 7 21 36 21 3 3 7 74 70 3 −13 −3 8 36 49 16 14 0 8 80 75 6 4 4 8 141129 3 −24 0 7 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268 5 −14 4 7 88 86 6 13 −3 8 58 63 15 −5 1 8 585 605 10−7 5 8 113 95 6 2 0 7 204 214 8 −12 4 7 52 46 8 15 −3 8 73 89 13 −3 1 8450 459 7 −5 5 8 125 121 5 4 0 7 547 532 10 −10 4 7 0 20 1 17 −3 8 48 5619 −1 1 8 384 391 6 −3 5 8 96 88 3 6 0 7 149 148 5 −8 4 7 310 323 5 −28−2 8 68 90 7 1 1 8 573 575 19 −1 5 8 49 49 5 8 0 7 208 209 3 −6 4 7 246240 5 −26 −2 8 44 47 12 3 1 8 141 138 4 11 5 8 34 39 17 10 0 7 42 42 7−4 4 7 59 64 4 −24 −2 8 60 61 9 5 1 8 263 248 4 13 5 8 34 36 14 12 0 7165 166 3 −2 4 7 84 69 3 −22 −2 8 69 78 9 7 1 8 243 234 3 −16 6 8 47 5514 14 0 7 0 9 1 0 4 7 62 57 4 −20 −2 8 47 44 10 9 1 8 31 42 11 −14 6 812 32 11 16 0 7 149 127 10 2 4 7 215 193 3 −18 −2 8 107 99 9 11 1 8 111104 5 −12 6 8 21 26 20 18 0 7 0 9 1 4 4 7 121 107 4 −16 −2 8 115 101 613 1 8 17 34 16 −10 6 8 55 54 8 20 0 7 112 104 6 6 4 7 51 58 10 −14 −2 8207 200 5 15 1 8 49 46 11 −8 6 8 47 38 13 22 0 7 0 13 1 8 4 7 150 158 7−12 −2 8 173 160 5 17 1 8 99 104 4 −6 6 8 54 43 4 −23 1 7 4 14 4 10 4 7123 127 6 −10 −2 8 286 284 6 19 1 8 53 52 7 4 6 8 0 32 1 −21 1 7 47 49 612 4 7 75 96 9 −8 −2 8 403 403 12 −28 2 8 34 90 34 6 6 8 57 64 5 −19 1 7240 229 3 16 4 7 40 48 23 −6 −2 8 241 221 6 −26 2 8 34 47 34 −21 −5 9 019 1 −17 1 7 95 82 5 −21 5 7 55 59 17 −4 −2 8 158 166 5 −24 2 8 34 61 34−19 −5 9 0 35 1 −15 1 7 95 98 3 −19 5 7 22 18 22 −2 −2 8 349 323 9 −22 28 67 78 15 −17 −5 9 27 20 26 −13 1 7 113 134 4 −17 5 7 56 79 11 0 −2 8124 110 5 −20 2 8 62 43 11 −15 −5 9 31 37 31 −11 1 7 146 161 7 −15 5 755 43 11 2 −2 8 221 214 5 −18 2 8 113 100 7 −13 −5 9 13 31 13 −9 1 7 212215 5 −13 5 7 18 39 18 4 −2 8 156 145 9 −16 2 8 117 100 3 −11 −5 9 46 5316 7 −5 9 33 40 32 11 −1 9 55 41 10 −3 3 9 71 64 3 1 −3 10 225 218 6 −91 10 412 408 6 9 −5 9 68 85 11 13 −1 9 107 91 9 −1 3 9 79 75 3 3 −3 1072 84 9 −7 1 10 232 229 4 11 −5 9 104 106 7 15 −1 9 13 24 13 1 3 9 203204 3 5 −3 10 100 96 7 −5 1 10 224 223 4 −24 −4 9 9 30 8 17 −1 9 54 4918 3 3 9 49 45 6 7 −3 10 30 24 29 −3 1 10 289 284 5 −22 −4 9 37 27 27 19−1 9 0 30 1 5 3 9 90 77 3 9 −3 10 109 90 10 −1 1 10 132 139 3 −20 −4 932 26 32 −28 0 9 24 35 23 7 3 9 44 35 7 11 −3 10 133 130 8 1 1 10 328341 4 −18 −4 9 81 93 10 −26 0 9 49 56 13 9 3 9 166 176 6 13 −3 10 67 6814 3 1 10 115 104 3 −16 −4 9 88 80 9 −24 0 9 29 39 29 11 3 9 88 107 1215 −3 10 76 61 11 5 1 10 122 118 3 −14 −4 9 50 33 12 −22 0 9 207 206 513 3 9 16 48 16 −28 −2 10 115 97 5 7 1 10 154 136 3 −12 −4 9 246 243 8−20 0 9 181 170 5 15 3 9 33 19 32 −26 −2 10 119 113 5 9 1 10 181 177 3−10 −4 9 115 117 6 −18 0 9 44 50 6 −24 4 9 33 30 33 −24 −2 10 58 40 9 111 10 33 33 32 −8 −4 9 240 235 6 −16 0 9 98 90 3 −22 4 9 0 27 1 −22 −2 1042 41 13 13 1 10 136 150 5 −6 −4 9 243 265 9 −14 0 9 100 101 4 −20 4 937 26 37 −20 −2 10 234 220 5 15 1 10 14 14 14 2 −4 9 193 182 8 −12 0 9260 261 5 −18 4 9 95 92 11 −18 −2 10 125 126 6 17 1 10 0 17 1 4 −4 9 6766 11 −10 0 9 641 625 11 −16 4 9 47 80 24 −16 −2 10 17 41 17 −28 2 10100 97 11 6 −4 9 154 132 8 −8 0 9 1007 926 17 −14 4 9 24 32 24 −14 −2 10211 200 7 −26 2 10 116 113 10 8 −4 9 132 141 9 −6 0 9 559 566 10 −12 4 9242 243 5 −12 −2 10 28 41 25 −24 2 10 43 40 37 10 −4 9 0 9 1 −4 0 9 410437 13 −10 4 9 130 118 4 −10 −2 10 224 228 5 −22 2 10 46 40 29 12 −4 971 50 13 −2 0 9 114 107 7 −8 4 9 240 235 4 −8 −2 10 207 195 4 −20 2 10234 220 7 14 −4 9 45 51 20 0 0 9 0 13 1 −6 4 9 267 265 5 −6 −2 10 144132 5 −18 2 10 129 127 5 −27 −3 9 27 5 26 2 0 9 142 138 5 −4 4 9 139 1373 −4 −2 10 212 201 3 −16 2 10 33 41 11 −25 −3 9 30 51 30 4 0 9 148 158 3−2 4 9 31 38 11 −2 −2 10 179 174 4 −14 2 10 207 200 3 −23 −3 9 77 83 116 0 9 371 334 5 0 4 9 84 79 3 0 −2 10 90 84 4 −12 2 10 37 42 8 −21 −3 990 110 9 8 0 9 10 21 9 2 4 9 184 182 3 2 −2 10 116 118 4 −10 2 10 212228 3 −19 −3 9 47 64 18 10 0 9 40 44 9 4 4 9 77 66 3 4 −2 10 47 59 9 −82 10 205 194 3 −17 −3 9 92 83 12 12 0 9 41 59 10 6 4 9 141 132 6 6 −2 1090 93 8 −6 2 10 144 133 3 −15 −3 9 109 107 11 14 0 9 0 7 1 8 4 9 134 1429 8 −2 10 150 152 16 −4 2 10 206 200 3 −13 −3 9 74 62 12 16 0 9 57 57 1710 4 9 26 9 25 10 −2 10 135 119 9 −2 2 10 175 174 2 −11 −3 9 129 133 1218 0 9 14 19 14 12 4 9 43 50 32 12 −2 10 31 35 30 0 2 10 83 84 3 −9 −3 9315 304 7 20 0 9 49 57 7 −21 5 9 29 19 28 14 −2 10 42 46 28 2 2 10 130117 3 −7 −3 9 187 188 5 −25 1 9 103 111 11 −19 5 9 33 35 32 16 −2 10 5768 17 4 2 10 72 60 5 −5 −3 9 155 156 5 −23 1 9 35 36 11 −17 5 9 12 20 12−29 −1 10 107 106 5 6 2 10 101 94 5 −3 −3 9 58 65 6 −21 1 9 64 58 5 −155 9 47 37 14 −27 −1 10 51 44 16 8 2 10 155 151 5 −1 −3 9 73 74 6 −19 1 9115 115 5 −13 5 9 37 31 21 −25 −1 10 82 89 9 10 2 10 117 119 8 1 −3 9200 205 9 −17 1 9 160 150 3 −11 5 9 45 52 14 −23 −1 10 145 135 5 12 2 1034 35 13 3 −3 9 52 46 11 −15 1 9 128 133 4 −9 5 9 8 12 7 −21 −1 10 74 835 14 2 10 37 46 10 5 −3 9 85 77 10 −13 1 9 91 75 4 −7 5 9 145 161 8 −19−1 10 255 258 5 16 2 10 44 68 29 7 −3 9 52 35 15 −11 1 9 64 67 6 −5 5 943 41 10 −17 −1 10 148 137 4 −27 3 10 70 81 14 9 −3 9 157 175 9 −9 1 9568 580 10 −3 5 9 105 93 3 −15 −1 10 159 160 4 −25 3 10 111 111 10 11 −39 100 107 10 −7 1 9 679 679 12 −1 5 9 186 186 3 −13 −1 10 218 209 4 −233 10 155 135 9 13 −3 9 37 48 37 −5 1 9 632 620 11 3 5 9 34 25 28 −11 −110 268 273 4 −21 3 10 17 43 16 15 −3 9 0 19 1 −3 1 9 291 281 5 11 5 9 84106 6 −9 −1 10 426 409 6 −19 3 10 85 86 12 17 −3 9 16 16 16 −1 1 9 169188 4 −16 6 9 51 50 12 −7 −1 10 234 229 5 −17 3 10 112 116 7 −28 −2 9 020 1 1 1 9 390 410 6 −14 6 9 44 47 11 −5 −1 10 225 224 6 −15 3 10 126113 15 −26 −2 9 103 87 6 3 1 9 371 364 4 −12 6 9 41 33 11 −3 −1 10 291284 7 −13 3 10 191 178 6 −24 −2 9 88 66 13 5 1 9 175 177 3 −10 6 9 35 4410 −1 −1 10 136 139 5 −11 3 10 329 330 4 −22 −2 9 75 82 7 7 1 9 337 3314 −8 6 9 33 46 9 1 −1 10 329 341 5 −9 3 10 198 193 3 −20 −2 9 38 33 25 91 9 96 107 4 4 6 9 38 49 6 3 −1 10 114 105 6 −7 3 10 221 223 3 −18 −2 910 21 9 11 1 9 39 41 13 6 6 9 33 41 7 5 −1 10 119 118 4 −5 3 10 125 1183 −16 −2 9 86 88 12 13 1 9 94 91 6 −21 −5 10 0 12 1 7 −1 10 158 137 4 −33 10 65 50 4 −14 −2 9 134 127 5 15 1 9 38 24 15 −19 −5 10 40 28 21 9 −110 171 176 10 −1 3 10 141 146 3 −12 −2 9 167 164 7 17 1 9 48 49 8 −17 −510 0 30 1 11 −1 10 25 33 24 1 3 10 221 219 3 −10 −2 9 59 56 7 −28 2 9 1620 16 −15 −5 10 43 30 19 13 −1 10 158 150 8 3 3 10 82 84 7 −8 −2 9 249271 4 −26 2 9 110 87 11 −13 −5 10 42 39 20 15 −1 10 19 14 18 5 3 10 10296 3 −6 −2 9 135 107 14 −24 2 9 56 66 20 −11 −5 10 55 57 13 17 −1 10 017 1 7 3 10 0 24 1 −4 −2 9 252 244 6 −22 2 9 86 82 12 7 −5 10 102 101 9−28 0 10 128 124 6 9 3 10 92 90 4 −2 −2 9 75 75 15 −20 2 9 46 33 17 9 −510 59 60 12 −26 0 10 128 123 7 11 3 10 119 130 10 0 −2 9 183 180 4 −18 29 23 21 15 −24 −4 10 52 9 14 −24 0 10 29 34 29 13 3 10 40 68 39 2 −2 9112 110 4 −16 2 9 95 88 3 −22 −4 10 61 55 13 −22 0 10 115 102 10 15 3 1053 61 20 4 −2 9 123 111 5 −14 2 9 128 127 3 −20 −4 10 117 128 8 −20 0 10251 255 8 −24 4 10 0 9 1 6 −2 9 65 80 9 −12 2 9 166 164 3 −18 −4 10 3956 23 −18 0 10 93 80 3 −22 4 10 0 55 1 8 −2 9 188 175 6 −10 2 9 63 56 4−16 −4 10 109 118 8 −16 0 10 73 74 4 −20 4 10 103 128 10 10 −2 9 44 4217 −8 2 9 246 271 3 −14 −4 10 6 5 5 −14 0 10 653 620 8 −18 4 10 63 56 1612 −2 9 143 151 9 −6 2 9 130 107 4 −12 −4 10 154 144 13 −12 0 10 173 1815 −16 4 10 112 118 10 14 −2 9 58 49 18 −4 2 9 251 243 4 −10 −4 10 204188 6 −10 0 10 354 302 6 −14 4 10 20 5 19 16 −2 9 40 38 19 −2 2 9 81 764 −8 −4 10 351 334 8 −8 0 10 264 271 5 −12 4 10 160 144 5 18 −2 9 12 2812 0 2 9 182 180 3 −6 −4 10 268 280 9 −6 0 10 444 458 8 −10 4 10 199 1875 −29 −1 9 41 38 40 2 2 9 114 111 2 2 −4 10 86 95 11 −4 0 10 324 302 6−8 4 10 357 334 4 −27 −1 9 45 31 15 4 2 9 116 111 3 4 −4 10 106 102 9 −20 10 179 183 4 −6 4 10 281 281 3 −25 −1 9 100 111 8 6 2 9 84 80 5 6 −410 98 68 10 0 0 10 218 211 3 −4 4 10 108 119 5 −23 −1 9 38 36 14 8 2 9188 175 3 8 −4 10 70 87 14 2 0 10 117 117 3 −2 4 10 114 111 3 −21 −1 960 57 6 10 2 9 23 42 23 10 −4 10 61 58 15 4 0 10 255 243 3 0 4 10 28 3713 −19 −1 9 114 115 5 12 2 9 154 151 7 12 −4 10 0 22 1 6 0 10 150 160 32 4 10 94 94 4 −17 −1 9 162 150 3 14 2 9 65 50 6 −27 −3 10 55 81 9 8 010 291 283 4 4 4 10 102 102 3 −15 −1 9 133 133 3 16 2 9 19 38 18 −25 −310 110 111 7 10 0 10 72 90 5 6 4 10 85 68 14 −13 −1 9 86 75 4 −27 3 9 05 1 −23 −3 10 151 135 8 12 0 10 0 4 1 8 4 10 55 87 12 −11 −1 9 70 66 5−25 3 9 37 51 36 −21 −3 10 0 43 1 14 0 10 57 42 8 10 4 10 23 59 23 −9 −19 590 580 20 −23 3 9 81 84 13 −19 −3 10 77 85 10 16 0 10 21 32 21 12 410 0 23 1 −7 −1 9 685 680 15 −21 3 9 78 110 12 −17 −3 10 120 116 9 18 010 0 16 1 −21 5 10 16 12 16 −5 −1 9 625 619 25 −19 3 9 79 64 12 −15 −310 129 113 11 −25 1 10 84 89 14 −19 5 10 0 28 1 −3 −1 9 286 280 7 −17 39 87 83 20 −13 −3 10 189 178 6 −23 1 10 148 135 9 −17 5 10 35 29 34 −1−1 9 172 190 5 −15 3 9 103 107 8 −11 −3 10 315 330 7 −21 1 10 78 83 6−15 5 10 48 30 14 1 −1 9 380 410 9 −13 3 9 72 62 10 −9 −3 10 195 192 5−19 1 10 250 258 4 −13 5 10 49 39 13 3 −1 9 364 363 5 −11 3 9 122 133 2−7 −3 10 220 223 5 −17 1 10 144 137 3 −11 5 10 73 58 8 5 −1 9 175 177 5−9 3 9 313 303 3 −5 −3 10 113 119 5 −15 1 10 162 160 4 −9 5 10 76 81 107 −1 9 334 331 7 −7 3 9 195 188 3 −3 −3 10 56 50 6 −13 1 10 217 209 3 −75 10 93 111 15 9 −1 9 101 106 5 −5 3 9 159 156 3 −1 −3 10 133 146 5 −111 10 264 274 4 −5 5 10 81 92 5 −3 5 10 207 207 3 −1 −1 11 191 208 4 −9 311 32 36 9 −24 −2 12 0 19 1 −28 2 12 0 23 1 −1 5 10 80 78 5 1 −11 1 104100 4 −7 3 11 70 67 4 −22 −2 12 126 119 17 −26 2 12 12 2 11 1 5 10 47 6812 3 −1 11 135 138 4 −5 3 11 34 35 9 −20 −2 12 118 135 5 −24 2 12 50 1924 3 5 10 59 75 12 5 −1 11 122 118 4 −3 3 11 163 159 4 −18 −2 12 231 2238 −22 2 12 118 119 10 −14 6 10 19 13 19 7 −1 11 74 74 8 −1 3 11 62 61 5−16 −2 12 166 161 6 −20 2 12 130 135 10 −12 6 10 38 40 11 9 −1 11 73 829 1 3 11 92 96 4 −14 −2 12 29 30 29 −18 2 12 225 223 4 −10 6 10 37 35 911 −1 11 97 104 7 3 3 11 71 71 5 −12 −2 12 19 28 19 −16 2 12 164 161 4−8 6 10 28 34 10 13 −1 11 25 16 24 5 3 11 51 50 8 −10 −2 12 55 68 13 −142 12 10 30 9 −19 −5 11 0 41 1 15 −1 11 28 49 27 7 3 11 92 92 4 −8 −2 120 10 1 −12 2 12 27 28 25 −17 −5 11 32 28 32 17 −1 11 23 4 23 9 3 11 7064 7 −6 −2 12 71 67 5 −10 2 12 62 67 7 −15 −5 11 45 52 17 −28 0 11 135125 10 11 3 11 91 103 12 −4 −2 12 199 197 4 −8 2 12 17 9 16 −13 −5 11 022 1 −26 0 11 30 26 30 13 3 11 53 60 18 −2 −2 12 119 109 4 −6 2 12 67 684 −11 −5 11 41 36 20 −24 0 11 32 6 25 −24 4 11 41 57 31 0 −2 12 59 58 7−4 2 12 196 197 3 −24 −4 11 63 57 11 −22 0 11 192 174 7 −22 4 11 25 6425 2 −2 12 109 121 5 −2 2 12 117 110 3 −22 −4 11 53 64 15 −20 0 11 211206 5 −20 4 11 89 73 12 4 −2 12 83 76 7 0 2 12 64 59 4 −20 −4 11 71 7311 −18 0 11 0 5 1 −18 4 11 38 36 37 6 −2 12 162 159 8 2 2 12 122 122 5−18 −4 11 59 37 13 −16 0 11 355 335 4 −16 4 11 12 12 12 8 −2 12 50 60 174 2 12 78 75 5 −16 −4 11 0 12 1 −14 0 11 128 119 3 −14 4 11 158 130 6 10−2 12 73 78 12 6 2 12 147 160 6 −14 −4 11 130 131 8 −12 0 11 328 331 4−12 4 11 379 361 8 12 −2 12 0 37 1 8 2 12 54 60 9 −12 −4 11 370 362 11−10 0 11 408 371 5 −10 4 11 247 228 4 14 −2 12 22 39 21 10 2 12 71 78 6−10 −4 11 241 227 8 −8 0 11 246 232 4 −8 4 11 39 33 7 −29 −1 12 31 37 2512 2 12 46 38 8 −8 −4 11 45 34 29 −6 0 11 214 203 3 −6 4 11 31 17 11 −27−1 12 84 63 9 14 2 12 26 39 26 −6 −4 11 0 17 1 −4 0 11 103 98 3 −4 4 11151 150 4 −25 −1 12 41 42 12 −25 3 12 22 14 22 2 −4 11 197 185 8 −2 0 11139 153 4 −2 4 11 155 159 4 −23 −1 12 91 75 6 −23 3 12 53 60 20 4 −4 11127 121 9 0 0 11 120 99 5 0 4 11 127 116 6 −21 −1 12 224 212 5 −21 3 12112 149 9 6 −4 11 26 27 25 2 0 11 261 259 4 2 4 11 189 186 3 −19 −1 12145 145 6 −19 3 12 91 130 11 8 −4 11 72 68 13 4 0 11 207 203 3 4 4 11110 120 3 −17 −1 12 102 106 9 −17 3 12 153 174 9 10 −4 11 44 54 24 6 011 61 64 6 6 4 11 36 26 33 −15 −1 12 272 254 5 −15 3 12 106 82 10 12 −411 0 65 1 8 0 11 89 95 4 8 4 11 61 68 10 −13 −1 12 141 137 3 −13 3 12 8382 4 −27 −3 11 73 75 6 10 0 11 71 83 7 10 4 11 21 54 20 −11 −1 12 111 985 −11 3 12 100 96 4 −25 −3 11 46 34 11 12 0 11 0 28 1 −19 5 11 56 41 10−9 −1 12 146 143 4 −9 3 12 175 183 3 −23 −3 11 48 28 17 14 0 11 15 10 15−17 5 11 42 27 13 −7 −1 12 246 238 4 −7 3 12 41 51 8 −21 −3 11 53 42 1316 0 11 42 29 26 −15 5 11 23 52 23 −5 −1 12 114 96 8 −5 3 12 67 58 5 −19−3 11 121 123 8 −25 1 11 0 35 1 −13 5 11 0 23 1 −3 −1 12 204 217 4 −3 312 65 58 4 −17 −3 11 235 248 8 −23 1 11 62 69 7 −11 5 11 52 36 10 −1 −112 306 303 5 −1 3 12 101 101 4 −15 −3 11 246 234 6 −21 1 11 86 74 5 −9 511 140 118 7 1 −1 12 78 68 8 1 3 12 94 86 5 −13 −3 11 127 134 7 −19 1 11376 361 6 −7 5 11 105 120 8 3 −1 12 108 99 6 3 3 12 211 209 6 −11 −3 11170 161 5 −17 1 11 142 126 5 −5 5 11 67 71 8 5 −1 12 195 204 4 5 3 12 4252 10 −9 −3 11 49 35 10 −15 1 11 192 183 3 −3 5 11 65 55 4 7 −1 12 143140 5 7 3 12 121 116 4 −7 −3 11 70 67 8 −13 1 11 233 221 3 −1 5 11 60 574 9 −1 12 67 58 9 9 3 12 138 131 9 −5 −3 11 0 35 1 −11 1 11 367 356 4 15 11 111 120 7 11 −1 12 32 27 32 11 3 12 32 62 32 −3 −3 11 153 159 4 −91 11 223 236 4 3 5 11 25 52 24 13 −1 12 28 47 27 13 3 12 25 42 25 −1 −311 57 61 9 −7 1 11 87 91 5 −14 6 11 43 46 9 15 −1 12 10 10 10 −24 4 1250 45 18 1 −3 11 94 96 7 −5 1 11 539 532 6 −12 6 11 45 48 8 −28 0 12 023 1 −22 4 12 0 29 1 3 −3 11 73 70 9 −3 1 11 165 172 3 −10 6 11 39 33 7−26 0 12 11 36 10 −20 4 12 82 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14 128 120 8 −191 14 101 98 6 −21 −3 15 0 24 1 −17 −3 13 90 125 8 −11 1 13 144 149 6 −10−4 14 40 38 25 −17 1 14 101 98 5 −19 −3 15 104 81 8 −15 −3 13 67 65 11−9 1 13 116 115 3 −8 −4 14 101 96 9 −15 1 14 345 321 6 −17 −3 15 64 5711 −13 −3 13 145 129 8 −7 1 13 73 63 5 −6 −4 14 21 48 21 −13 1 14 311293 4 −15 −3 15 47 33 16 −11 −3 13 75 80 8 −5 1 13 253 244 3 2 −4 14 6463 13 −11 1 14 96 89 5 −13 −3 15 158 138 7 −9 −3 13 0 19 1 −3 1 13 186186 4 4 −4 14 38 31 32 −9 1 14 74 61 5 −11 −3 15 78 69 11 −7 −3 13 66 809 −1 1 13 28 31 16 6 −4 14 21 25 20 −7 1 14 89 92 4 −9 −3 15 65 53 14 −5−3 13 51 43 10 1 1 13 230 220 3 −25 −3 14 29 24 29 −5 1 14 165 143 3 −7−3 15 64 83 14 −3 −3 13 153 159 5 3 1 13 83 69 5 −23 −3 14 59 50 12 −3 114 160 164 8 −5 −3 15 94 100 7 −1 −3 13 101 109 6 5 1 13 220 212 7 −21−3 14 38 45 24 −1 1 14 306 301 4 −3 −3 15 156 155 8 1 −3 13 54 31 17 7 113 152 152 5 −19 −3 14 57 65 12 1 1 14 367 351 5 −1 −3 15 58 65 16 3 −313 83 57 11 9 1 13 31 24 21 −17 −3 14 72 91 9 3 1 14 137 130 5 1 −3 15139 141 8 5 −3 13 129 134 9 11 1 13 51 63 13 −15 −3 14 74 87 10 5 1 1472 77 7 3 −3 15 76 60 13 7 −3 13 108 114 10 13 1 13 59 55 9 −13 −3 14149 132 8 7 1 14 140 124 5 5 −3 15 19 15 18 9 −3 13 45 67 22 −28 2 13 027 1 −11 −3 14 29 27 29 9 1 14 14 31 14 7 −3 15 46 34 19 11 −3 13 44 4220 −26 2 13 92 72 11 −9 −3 14 0 27 1 11 1 14 93 94 5 −26 −2 15 50 55 9−28 −2 13 28 27 28 −24 2 13 57 82 18 −7 −3 14 122 116 8 −26 2 14 0 24 1−24 −2 15 57 82 9 −26 −2 13 84 72 6 −22 2 13 50 68 22 −5 −3 14 131 128 5−24 2 14 28 36 28 −22 −2 15 75 84 8 −24 −2 13 55 82 9 −20 2 13 169 184 5−3 −3 14 50 38 12 −22 2 14 90 80 11 −20 −2 15 190 185 8 −22 −2 13 49 6811 −18 2 13 62 55 7 −1 −3 14 188 163 8 −20 2 14 160 160 4 −18 −2 15 118134 8 −20 −2 13 179 184 7 −15 2 13 38 45 12 1 −3 14 220 205 8 −18 2 14101 94 5 −16 −2 15 80 87 9 −18 −2 13 64 54 12 −14 2 13 185 189 4 3 −3 14195 186 7 −16 2 14 192 186 5 −14 −2 15 80 61 10 −16 −2 13 51 45 12 −12 213 137 126 4 5 −3 14 78 81 12 −14 2 14 112 109 4 −12 −2 15 13 51 12 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14 118 128 4 −3 −1 15 193 194 6 −11 −1 13 144 149 4 −3 3 13 157 1583 −21 −1 14 77 111 10 −3 3 14 30 38 16 −1 −1 15 307 295 7 −9 −1 13 116116 4 −1 3 13 108 110 9 −19 −1 14 91 98 6 −1 3 14 176 163 5 1 −1 15 6960 9 −7 −1 13 66 63 6 1 3 13 41 32 16 −17 −1 14 107 99 5 1 3 14 211 2056 3 −1 15 147 150 6 −5 −1 13 255 244 4 3 3 13 64 58 6 −15 −1 14 351 3215 3 3 14 177 186 4 5 −1 15 74 84 9 −3 −1 13 185 186 4 5 3 13 125 134 12−13 −1 14 311 294 6 5 3 14 68 81 6 7 −1 15 40 28 17 −1 −1 13 0 31 1 7 313 120 115 7 −11 −1 14 92 90 8 7 3 14 23 37 23 9 −1 15 25 54 25 1 −1 13230 220 4 9 3 13 51 67 20 −9 −1 14 69 60 6 9 3 14 27 39 27 −28 0 15 0 31 3 −1 13 92 69 6 11 3 13 42 41 24 −7 −1 14 84 92 5 −22 4 14 34 11 34−26 0 15 82 64 7 5 −1 13 216 211 7 −22 4 13 38 21 25 −5 −1 14 152 142 7−20 4 14 37 56 28 −24 0 15 52 41 13 7 −1 13 148 152 6 −20 4 13 18 46 17−3 −1 14 155 165 9 −18 4 14 69 68 12 −22 0 15 34 1 33 9 −1 13 36 24 21−18 4 13 0 33 1 −1 −1 14 311 302 6 −16 4 14 83 90 12 −20 0 15 38 25 1411 −1 13 65 64 9 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17 54 65 15 −19 1 18 52 37 10 −182 15 119 134 5 −23 −1 16 26 27 26 −8 4 16 131 121 7 −20 2 17 0 4 1 −17 118 0 14 1 −16 2 15 77 87 7 −21 −1 16 190 161 5 −6 4 16 61 62 6 −18 2 1774 81 7 −15 1 18 34 35 34 −14 2 15 70 60 7 −19 −1 16 70 95 8 −4 4 16 3438 13 −16 2 17 38 39 13 −13 1 18 144 153 6 −12 2 15 49 51 13 −17 −1 1690 84 17 −2 4 16 56 57 6 −14 2 17 40 39 13 −11 1 18 101 93 7 −10 2 15277 245 5 −15 −1 16 59 48 10 0 4 16 24 40 14 −12 2 17 122 145 6 −9 1 1833 28 17 −8 2 15 132 121 8 −13 −1 16 69 86 9 −16 −4 17 26 49 25 −10 2 1730 30 30 −7 1 18 68 60 7 −6 2 15 162 154 4 −11 −1 16 60 52 10 −14 −4 175 33 4 −8 2 17 121 113 6 −5 1 18 108 94 11 −4 2 15 101 98 5 −9 −1 16 175177 6 −12 −4 17 75 67 10 −6 2 17 51 58 8 −3 1 18 28 9 27 −2 2 15 70 75 6−7 −1 16 207 207 8 −10 −4 17 40 17 22 −4 2 17 61 67 7 −1 1 18 43 36 11 02 15 240 237 9 −5 −1 16 167 168 6 −21 −3 17 0 7 1 −2 2 17 0 7 1 1 1 1866 71 7 2 2 15 33 33 17 −3 −1 16 25 47 25 −19 −3 17 21 29 20 0 2 17 1429 13 3 1 18 32 38 15 4 2 15 30 43 29 −1 −1 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−3 19 30 2530 −10 4 15 62 51 9 −23 1 16 34 27 17 4 −2 17 43 39 23 −13 −3 18 38 2738 −13 −3 19 53 42 16 −8 4 15 65 65 5 −21 1 16 170 162 12 −25 −1 17 0 171 −11 −3 18 70 99 12 −11 −3 19 0 17 1 −6 4 15 85 89 5 −19 1 16 96 95 11−23 −1 17 124 129 8 −9 −3 18 20 16 20 −9 −3 19 32 48 32 −4 4 15 120 1465 −17 1 16 89 83 7 −21 −1 17 21 3 21 −7 −3 18 65 54 13 −7 −3 19 12 40 12−2 4 15 37 35 12 −15 1 16 46 49 12 −19 −1 17 49 67 26 −5 −3 18 26 30 25−20 −2 19 32 14 32 0 4 15 20 20 20 −13 1 16 83 85 6 −17 −1 17 25 20 25−3 −3 18 59 48 13 −18 −2 19 35 47 35 2 4 15 72 77 7 −11 1 16 39 52 16−15 −1 17 27 55 27 −1 −3 18 23 26 22 −16 −2 19 38 21 34 4 4 15 29 22 29−9 1 16 165 178 7 −13 −1 17 102 114 7 −22 −2 18 0 17 1 −14 −2 19 86 6411 −13 5 15 55 60 10 −7 1 16 200 207 6 −11 −1 17 189 173 8 −20 −2 18 1725 17 −12 −2 19 97 93 10 −11 5 15 52 46 11 −5 1 16 157 167 8 −9 −1 17105 114 6 −18 −2 18 0 13 1 −10 −2 19 0 16 1 −9 5 15 68 68 6 −3 1 16 4647 16 −7 −1 17 47 17 13 −16 −2 18 67 97 13 −8 −2 19 41 33 17 −7 5 15 5853 9 −1 1 16 106 123 17 −5 −1 17 128 105 9 −14 −2 18 31 48 30 −6 −2 1933 34 25 −5 5 15 28 35 11 1 1 16 18 31 17 −3 −1 17 126 111 18 −12 −2 1861 45 15 −4 −2 19 32 27 31 −18 −4 16 59 53 12 3 1 16 20 38 19 −1 −1 17 023 1 −10 −2 18 110 108 6 −2 −2 19 59 57 14 −16 −4 16 17 29 17 5 1 16 8365 9 1 −1 17 54 64 12 −8 −2 18 41 77 30 −21 −1 19 75 73 8 −14 −4 16 2 312 7 1 16 0 18 1 3 −1 17 0 12 1 −6 −2 18 39 38 21 −19 −1 19 0 26 1 −12 −416 50 41 16 −24 2 16 67 70 12 5 −1 17 22 15 22 −4 −2 18 45 51 14 −17 −119 0 28 1 −10 −4 16 72 94 10 −22 2 16 54 65 15 −26 0 17 71 56 7 −2 −2 1857 64 17 −15 −1 19 60 40 10 −8 −4 16 126 121 8 −20 2 16 86 114 10 −24 017 17 15 17 0 −2 18 14 27 14 −13 −1 19 69 55 9 −23 −3 16 40 34 17 −18 216 108 122 8 −22 0 17 38 25 37 2 −2 18 0 10 1 −11 −1 19 73 74 9 −21 −316 29 41 29 −16 2 16 20 28 19 −20 0 17 42 28 13 −23 −1 18 68 67 8 −9 −119 66 70 10 −19 −3 16 0 11 1 −14 2 16 43 61 12 −18 0 17 14 35 13 −21 −118 30 40 30 −7 −1 19 22 34 21 −17 −3 16 58 48 13 −12 2 16 21 29 20 −16 017 127 120 5 −19 −1 18 35 37 35 −5 −1 19 0 6 1 −15 −3 16 47 71 18 −10 216 136 129 5 −14 0 17 179 158 5 −17 −1 18 7 14 6 −3 −1 19 0 10 1 −13 −316 59 52 14 −8 2 16 50 48 11 −12 0 17 202 206 8 −15 −1 18 24 35 23 −1 −119 56 49 11 −11 −3 16 59 48 15 −6 2 16 156 159 5 −10 0 17 110 89 13 −13−1 18 153 153 18 1 −1 19 19 27 19 −9 −3 16 63 74 14 −4 2 16 102 104 8 −80 17 0 21 1 −11 −1 18 99 93 10 −22 0 19 0 46 1 −7 −3 16 34 21 34 −2 2 1628 44 23 −6 0 17 80 85 7 −9 −1 18 0 27 1 −20 0 19 34 47 17 −5 −3 16 4352 14 0 2 16 89 78 5 −4 0 17 113 161 6 −7 −1 18 66 59 10 −18 0 19 28 2228 −3 −3 16 110 106 9 2 2 16 46 40 10 −2 0 17 64 62 9 −5 −1 18 106 94 7−16 0 19 45 40 12 −1 −3 16 49 66 19 4 2 16 12 21 12 0 0 17 91 104 7 −3−1 18 0 9 1 −14 0 19 36 33 17 1 −3 16 30 14 29 6 2 16 21 22 21 2 0 17 2543 24 −1 −1 18 32 36 31 −12 0 19 41 33 14 3 −3 16 42 52 30 −23 3 16 3034 30 4 0 17 53 51 9 1 −1 18 81 71 11 −10 0 19 125 108 6 5 −3 16 14 1513 −21 3 16 43 41 19 6 0 17 73 70 6 3 −1 18 46 38 19 −8 0 19 0 8 1 −24−2 16 52 70 9 −19 3 16 22 11 22 −25 1 17 37 17 37 −24 0 18 0 23 1 −6 019 45 28 15 −22 −2 16 47 64 11 −17 3 16 68 47 12 −23 1 17 132 129 9 −220 18 28 38 28 −4 0 19 36 23 22 −20 −2 16 88 114 9 −15 3 16 70 71 10 −211 17 0 3 1 −20 0 18 28 6 27 −2 0 19 33 44 32 −18 −2 16 92 122 9 −13 3 1646 52 10 −19 1 17 65 67 9 −18 0 18 0 3 1 0 0 19 81 64 15 −16 −2 16 22 2822 −11 3 16 54 48 9 −17 1 17 42 20 17 −16 0 18 45 71 12 −21 1 19 67 73 6−14 −2 16 66 62 12 −9 3 16 62 73 8 −15 1 17 40 55 14 −14 0 18 0 48 1 −191 19 0 26 1 −12 −2 16 51 29 16 −7 3 16 27 21 27 −13 1 17 91 114 10 −12 018 17 24 16 −17 1 19 28 28 27 −10 −2 16 131 129 6 −5 3 16 56 51 8 −11 117 176 173 11 −10 0 18 42 56 17 −15 1 19 55 40 12 −8 −2 16 41 48 16 −3 316 110 106 4 −9 1 17 107 113 5 −8 0 18 74 95 8 −13 1 19 61 55 8 −11 1 1969 74 7 −6 2 19 24 34 24 −19 −1 20 40 58 16 −10 0 20 0 0 1 −14 2 20 4047 39 −9 1 19 64 71 8 −4 2 19 38 27 10 −17 −1 20 0 39 1 −8 0 20 0 23 1−12 2 20 23 14 22 −7 1 19 27 34 27 −2 2 19 60 57 6 −15 −1 20 0 34 1 −6 020 13 32 12 −10 2 20 33 48 16 −5 1 19 4 6 3 −15 3 19 47 25 15 −13 −1 2069 62 21 −4 0 20 19 12 19 −8 2 20 63 66 10 −3 1 19 0 10 1 −13 3 19 48 426 −11 −1 20 0 15 1 −19 1 20 47 58 9 −6 2 20 29 23 15 −1 1 19 55 49 8 −113 19 0 17 1 −9 −1 20 33 21 32 −17 1 20 31 39 30 −13 −1 21 26 20 25 1 119 36 27 12 −9 3 19 46 48 8 −7 −1 20 49 13 13 −15 1 20 45 34 10 −11 −121 29 22 29 −20 2 19 27 14 26 −7 3 19 34 40 12 −5 −1 20 41 29 17 −13 120 53 62 9 −16 0 21 0 27 1 −18 2 19 56 47 15 −16 −2 20 25 14 25 −3 −1 2027 24 26 −11 1 20 19 15 18 −14 0 21 24 5 24 −16 2 19 29 21 28 −14 −2 2042 47 25 −20 0 20 59 58 8 −9 1 20 18 21 17 −12 0 21 11 6 11 −14 2 19 8163 14 −12 −2 20 0 14 1 −18 0 20 51 20 9 −7 1 20 0 13 1 −10 0 21 25 36 25−12 2 19 101 93 11 −10 −2 20 52 48 11 −16 0 20 58 54 8 −5 1 20 21 29 21−8 0 21 0 10 1 −10 2 19 20 16 20 −8 −2 20 76 66 7 −14 0 20 14 21 14 −3 120 31 24 16 −13 1 21 0 20 1 −8 2 19 28 34 28 −6 −2 20 30 23 29 −12 0 2029 37 29 −16 2 20 0 14 1 −11 1 21 41 21 15

REFERENCES

-   1. CrysAlis RED, Oxford Diffraction Ltd., Version 1.171.28 cycle2    beta (release Oct. 25, 2005 CrysAlis171.NET) (compiled Oct. 25,    2005, 08:50:05). Empirical absorption correction using spherical    harmonics, implemented in SCALE3 ABSPACK scaling algorithm.-   2. CrysAlis CCD, Oxford Diffraction Ltd., Version 1.171.28 cycle2    beta; CrysAlis RED, Oxford Diffraction Ltd., Version 1.171.28 cycle2    beta.-   3. G. M. Sheldrick, Acta Crystallogr. 1990, A46, 467-473.-   4. G. M. Sheldrick, SHELXL93. Program for the Reminement of Crystal    Structures, Univ. of Göttingen, Germany.-   5. International Tables for Crystallography, Ed. A. J. C. Wilson,    Kluwer:Dordrecth, 1992, Vol. C.

Example 3 Synthesis of MET-1 and MET-2

The preparation of MET-1 and MET-2 having the basic structures I and IIcan be accomplished by a common general method otherwise referred to asthe condensation of a bicyclic Windaus-Grundmann type ketone IIIa orIIIb with the allylic phosphine oxide IV to the corresponding2-methylene-19-nor-vitamin D analog Va or Vb followed by deprotection atC-1 and C-3 in the latter compound Va or Vb to obtain compound I (MET-1)or compound II (MET-2).

In phosphine oxide IV, Y₁ and Y₂ are preferably hydroxy-protectinggroups such as silyl protecting groups. The t-butyldimethylsilyl (TMDMS)group is an example of a particularly useful hydroxy-protecting group.The process described above represents an application of the convergentsynthesis concept, which has been applied effectively to the preparationof numerous vitamin D compounds. (See Lythgoe et al., J. Chem. Soc.Perkin Trans. I, 590 (1978); Lythgoe, Chem. Soc. Rev. 9, 449 (1983); Tohet al., J. Org. Chem. 48, 1414 (1983); Baggiolini et al., J. Org. Chem.51, 3098 (1986); Sardina et al., J. Org. Chem. 51, 1264 (1986); J. Org.Chem. 51, 1269 (1986); DeLuca et al., U.S. Pat. No. 5,086,191; DeLuca etal., U.S. Pat. No. 5,536,713; and DeLuca et al., U.S. Pat. No. 5,843,928all of which are hereby incorporated by reference in their entirety andfor all purposes as if fully set forth herein).

Phosphine oxide IV is a convenient reagent that can be used to prepare alarge number of 19-nor-vitamin D compounds and is prepared according tothe procedures described by Sicinski et al., J. Med. Chem., 41, 4662(1998); DeLuca et al., U.S. Pat. No. 5,843,928; Perlman et al.,Tetrahedron Lett. 32, 7663 (1991); and DeLuca et al., U.S. Pat. No.5,086,191; which are hereby incorporated by reference in their entiretyas if fully set forth herein.

An overall process for the synthesis of compounds I and II isillustrated and described more completely in U.S. Pat. No. 5,843,928entitled “2-Alkylidene-19-Nor-Vitamin D Compounds” and in U.S. patentapplication Ser. No. 13/053,844 filed Mar. 22, 2011, entitled“(20S)-2-Methylene-19-Nor-22-Dimethyl-1α,25-Dihydroxyvitamin D₃ and(20R)-2-Methylene-19-Nor-22-Dimethyl-1α,25-Hydroxyvitamin D₃” publishedas U.S. Publication No. US 2011/0237556A1 the specification of which isspecifically incorporated herein by reference.

We claim:
 1. A compound having the formula

in crystalline form, wherein the methyl group attached to carbon 20 maybe in its R or S orientation. 2.(20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ incrystalline form.
 3. A crystalline form of(20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ havingmolecular packing arrangement defined by space group P2(1) and unit celldimensions a=7.57 Å b=14.79 Å c=14.48 Å α=90°, β=102.2° and γ=90°.
 4. Athree dimensional structure for(20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ asdefined by the molecular packing arrangement set forth in claim
 3. 5. Amethod of purifying(20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃,comprising the steps of: (a) preparing a solvent comprising diethylether; (b) dissolving a product containing(20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ to bepurified in said solvent; (c) cooling said solvent and dissolved productbelow ambient temperature for a sufficient amount of time to form aprecipitate of(20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ crystals;and (d) separating the(20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ crystalsfrom the solvent.
 6. The method of claim 5 including the further step ofallowing said solvent and dissolved product to cool to ambienttemperature prior to cooling below ambient temperature.
 7. The method ofclaim 5 wherein said solvent comprises 100% diethyl ether, by volume. 8.The method of claim 5 wherein the step of separating comprises filteringthe solvent and precipitate to obtain the crystals.
 9. The method ofclaim 5 including a further step (e) comprising repeating steps (a)through (d) using the recovered crystals from step (d) as the product ofstep (b). 10.(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ incrystalline form.
 11. A crystalline form of(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ havingmolecular packing arrangement defined by space group C2 and unit celldimensions a=27.33 Å b=6.68 Å c=19.22 Å α=90°, β=113.57° and γ=90°. 12.A three dimensional structure for(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ asdefined by the molecular packing arrangement set forth in claim
 11. 13.A method of purifying(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃,comprising the steps of: (a) preparing a solvent comprising hexane; (b)adding a product containing(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ to bepurified to said hexane to form a suspension of the product in thehexane; (c) adding 2-propanol dropwise to the suspension to form amixture of the product in the hexane and 2-propanol; (d) heating themixture to dissolve the product containing(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ to bepurified in said mixture; (e) cooling said mixture and dissolved productbelow ambient temperature for a sufficient amount of time to form aprecipitate of(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ crystals;and (f) separating the(20R)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D₃ crystalsfrom the mixture.
 14. The method of claim 13 including the further stepof allowing said mixture and dissolved product to cool to ambienttemperature prior to cooling below ambient temperature.
 15. The methodof claim 13 wherein the step of separating comprises filtering themixture and precipitate to obtain the crystals.
 16. The method of claim13 including a further step (g) comprising repeating steps (a) through(f) using the recovered crystals from step (f) as the product of step(b).
 17. The method of claim 13 wherein said mixture comprises about 15%2-propanol and about 85% hexane, by volume.